Cross-Talks between the Cardiovascular Disease-Sarcopenia-Osteoporosis Triad and Magnesium in Humans

Pickering, Marie-Eva

doi:10.3390/ijms22169102

Cited by 9 publications

(3 citation statements)

References 143 publications

(251 reference statements)

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“…Sarcopenia is associated with various adverse outcomes including frequent falls, osteoporosis, cardiovascular events, and mortality. 3 , 4 However, variable definitions and criteria for sarcopenia using different cutoff values and measurement tools have led to difficulties in standardizing these definitions, as well as the application of sarcopenia in clinical practice. Nonetheless, in recent years, various leading groups, including the International Working Group on Sarcopenia, Asian Working Group for Sarcopenia (AWGS), and European Working Group on Sarcopenia in Older People (EWGSOP2), have attempted to create a standardized definition and diagnosis of sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

Appendicular Skeletal Muscle Mass Associated with Sarcopenia as a Predictor of Poor Functional Outcomes in Ischemic Stroke

Lee¹,

Choi²,

Kim³

et al. 2023

CIA

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Several studies have examined the clinical impact of poststroke and stroke-related sarcopenia on stroke recovery. However, few studies have investigated the effect of sarcopenia detected shortly after stroke on functional prognosis. We predicted functional outcomes using early screening for sarcopenia in patients with acute ischemic stroke. We also examined the effect of sarcopenia detected shortly after stroke on functional prognosis. Patients and Methods: Patients diagnosed with acute ischemic stroke within 2 days of symptom onset were consecutively enrolled at a tertiary university hospital. Appendicular skeletal muscle mass (ASM) was measured using dual-energy X-ray absorptiometry during early hospitalization. Sarcopenia was diagnosed based on low ASM and strength criteria of the Asian Working Group for Sarcopenia (AWGS) and European Working Group on Sarcopenia in Older People (EWGSOP2). The primary outcome was poor functional outcome, defined as a modified Rankin score of 4-6 and all-cause mortality at 3 months. Results: Of the 653 patients, 214 (32.8%) and 174 (26.6%) had sarcopenia according to the AWGS and EWGSOP2 criteria, respectively. Irrespective of the definition, the sarcopenia group had a significantly higher proportion of patients with poor functional outcomes and all-cause mortality. Multivariate logistic regression analysis revealed that height-adjusted ASM was independently associated with poor functional outcomes (odds ratio: 0.61; 95% confidence interval: 0.40-0.91; P <0.005), and they were negatively correlated. However, the association between 3-month mortality, skeletal muscle mass, and sarcopenia was not sustained in multivariate analyses. Conclusion: Height-adjusted ASM associated with sarcopenia is a potential predictor of poor functional outcomes at 3 months in patients with acute stroke. However, owing to the limitations of this study, further research is required to confirm these findings.

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Section: Introductionmentioning

confidence: 99%

Appendicular Skeletal Muscle Mass Associated with Sarcopenia as a Predictor of Poor Functional Outcomes in Ischemic Stroke

Lee¹,

Choi²,

Kim³

et al. 2023

CIA

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“…About 1/3 of new radiologically visible vertebral deformations in post‐menopausal women are associated with a clinical diagnosis of fracture and for 2/3 of these patients, a diagnosis of spinal or disc pain is given (Nevitt et al, 1998). The fracture usually heals in several weeks but pain may become chronic with possible peripheral and central sensitization, increased morbidity and mortality (Marrinan et al, 2015; Pickering, 2021). OP pain may also add to osteoarthritis, low back pain, cancer bone pain (Casiano et al, 2022; Knezevic et al, 2021; Mantyh, 2019) and is a challenge for clinicians, as patients are usually older, with comorbidities and multiple drug treatments (Mitchell et al, 2018; Pickering et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Osteoporosis treatment and pain relief: A scoping review

Pickering¹,

Javier

Malochet³

et al. 2023

European Journal of Pain

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Background and ObjectiveAnti‐osteoporosis (OP) drugs have been suggested to contribute to pain reduction during OP management. This scoping review aimed at mapping the literature on pain relief with anti‐OP drugs in OP treatment.Databases and Data TreatmentMedline, Pubmed and Cochrane databases were searched by two reviewers with keywords combinations. Randomized controlled and real‐life English studies, pain as an endpoint, antiosteoporosis drugs were inclusion criteria. Case reports, surveys, comment letters, conference abstracts, animal studies and grey literature were excluded. Predetermined data were extracted by two reviewers and disagreement solved through discussion.ResultsA total of 130 articles were identified, 31 publications were included, 12 randomized clinical trials and 19 observational studies. Pain reduction was assessed by different tools: Visual Analogue Scale, Verbal Rating Scale, Facial Scale or as a domain of quality of life questionnaires including Short form 8, 36, mini‐OP, Japanese OP, Qualeffo, Roland Morris Disability questionnaires. Collective data show that anti‐OP drugs may display an analgesic effect that may be linked to the local mode of action of drugs on bone and consecutive modulation of pain sensitization. The methodology of the studies showed a heterogeneity of endpoints, comparators, statistical approaches and follow‐up duration.ConclusionConsidering the limitations of the literature, there is a need for more rigorous trials and larger real‐life studies taking into account the recommendations published for research in rheumatology and in pain medicine. The identification of responders, patient subtypes, and of analgesic‐effect doses would allow optimization and individualization for pain relief in patients with OP.Significance StatementThis scoping review shows that anti‐OP drugs may improve pain and quality of life of patients with OP. The heterogeneity in design, choice of endpoints, methodology, comparators and follow‐up duration of included randomized clinical trials and real‐life studies does not allow so far to identify a predominant antiosteoporosis drug or an optimal dosage for pain relief. These gaps need to be addressed and warrant further research in the future for optimizing pain improvement in the course of OP drug treatment.

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“…In addition, several studies have evaluated the simple effect of changes in body composition, such as muscle mass or fat distribution, on vascular stiffness. Osteoporosis, sarcopenia, and vascular disease may share common basic mechanisms, and risk factors in aging [18,19]. Conversely, osteoporosis, muscle dysfunction or sarcopenia, or VC and dysfunction develop individually or in complex patterns, simultaneously, in patients with CKD-MBD with protein energy wasting, regardless of age.…”

Section: Introductionmentioning

confidence: 99%

Moderating Effect of the Lean Tissue Index on the Relationship between the Trabecular Bone Score and Augmentation Index in Dialysis Naïve Patients with Stage 5 Chronic Kidney Disease

Han

Pak

Lee

et al. 2022

JCM

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Osteopenia, sarcopenia, and increased vascular stiffness are common in patients with chronic kidney disease-mineral bone disorder (CKD-MBD) with protein energy wasting and can lead to worse clinical outcomes. We investigated the potential moderating role of the lean tissue index (LTI) in the relationship between bone microarchitecture and vascular stiffness in dialysis naïve patients with stage 5 CKD. Bioimpedance spectroscopy for evaluating LTI, lumbar spine dual energy X-ray absorptiometry for determining the trabecular bone score (TBS), and arterial applanation tonometry measurements for the central augmentation index, at a heart rate of 75 beats/minute (cAIx75), were simultaneously performed in 117 consecutive patients. A hierarchical regression analysis was conducted to assess the moderating effect of LTI on the relationship between TBS and cAIx75 after adjusting for age and sex. The effect of the interaction between LTI and TBS on cAIx75 was statistically significant (p = 0.030), demonstrating that the cAIx75 tends to decrease more, with the joint effect of LTI and TBS. In the separate analyses, the interaction effect was significant only in women (p = 0.048) and the group of diabetes (p = 0.042). Our study suggests that the evaluation of changes in body composition, bone health, and vascular stiffness needs to be performed simultaneously in patients with advanced-stage CKD. Further research in patients with different stages of CKD warranted to generalize and apply our results to patients in other stages.

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Cross-Talks between the Cardiovascular Disease-Sarcopenia-Osteoporosis Triad and Magnesium in Humans

Cited by 9 publications

References 143 publications

Appendicular Skeletal Muscle Mass Associated with Sarcopenia as a Predictor of Poor Functional Outcomes in Ischemic Stroke

Appendicular Skeletal Muscle Mass Associated with Sarcopenia as a Predictor of Poor Functional Outcomes in Ischemic Stroke

Osteoporosis treatment and pain relief: A scoping review

Moderating Effect of the Lean Tissue Index on the Relationship between the Trabecular Bone Score and Augmentation Index in Dialysis Naïve Patients with Stage 5 Chronic Kidney Disease

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