Crosslinked bacterial cellulose hydrogels for biomedical applications

Almeida, Ana P. C.; Saraiva, João N.; Cavaco, Gonçalo; Portela, Raquel; Leal, Catarina R.; Almeida, Pedro L.

doi:10.1016/j.eurpolymj.2022.111438

Cited by 34 publications

(20 citation statements)

References 42 publications

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“…The following substances could be used as crosslinking agents: epichlorohydrin, glutaraldehyde, and citric acid, the latter being used more and more because the other listed substances are toxic [ 33 , 35 ]. Not only CMC, but also BC could be crosslinked using citric acid to obtain hydrogels with biomedical applications, including wound dressing [ 36 , 37 ]. The carboxylate moiety of citric acid could react with the hydroxyl moiety of both BC and CMC to form crosslinks between the two molecules.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications

Isopencu

Deleanu

Busuioc

et al. 2023

IJMS

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Bacterial cellulose (BC) is a biopolymer whose properties have been intensively studied, especially for biomedical applications. Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications. Another drawback of BC is the loss if its water retention capacity after dehydration. In order to overcome these problems, carboxymethyl cellulose (CMC) and turmeric extract (TE) were selected for the preparation of BC composites. Citric acid (CA) was used as the crosslinking agent. These composites were tested as potential antimicrobial wound dressing materials. TE-loaded BC–CMC composites were characterized in terms of their morphology, crystallinity, and thermal behavior. Swelling tests and curcumin-release kinetic analysis were also performed. All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds. The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans). The in vitro cytotoxicity toward L929 fibroblast cells was studied as well. The obtained results allow us to recommend these composites as good candidates for wound dressing applications.

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Section: Introductionmentioning

confidence: 99%

Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications

Isopencu

Deleanu

Busuioc

et al. 2023

IJMS

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“…The peaks in the range of 1500–1200 cm −1 are sensitive to chemical and molecule structural transformations. The peaks at 1159 and 1053 cm −1 correspond to stretching C–O–C and C–O vibrations 43 . The region of 847 cm −1 characterizes the β‐1,4 bond vibrations.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, materials with BC intensify mass loss in the range of 200–380°C, characteristic of the depolymerization process, decomposition of glycosidic units, and formation of gaseous residues 43,59 . The last stage of materials degradation between 440 and 550°C was due to the thermal degradation of isocyanates and aromatic compounds 65 .…”

Section: Resultsmentioning

confidence: 99%

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Bacterial cellulose‐modified castor oil‐based polyurethane sponge for hexavalent chromium removal

Maia,

Pinhati,

Monteceli

et al. 2023

J of Applied Polymer Sci

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Due to the multiple industrial applications of chromium compounds and their dangerous nature for the environment, the development of adsorbent materials has been investigated. In line with this reality, bacterial cellulose (BC) has become a potential filler in the polymeric matrix due to its ability to remove toxic metals; however, its performance is little explored. This research proposes a new approach for BC as a filler in castor oil‐based polyurethane, obtaining a sponge for Cr(VI) removal. The pure PU and PU + X%BC sponges (X stands for BC content between 5 and 20 wt%) were characterized by Fourier‐transform infrared spectroscopy, scanning electron microscopy, optical microscopy, density, contact angle (CA), and thermogravimetric analysis. Sorption capacity and efficiency were evaluated as a function of the fiber content, with tests performed in function of contact time (2.5 min to 3 h) at 50 mg L−1. The BC fillers of the sponges increased the density and influenced the morphological, chemical structural, thermal, and sorption properties. Thus, the sponge (PU + 20%BC) presented the highest CA (104.4°) and the best sorption capacity and efficiency (4.3 mg g−1 and 43.2%). The sorption mechanism was well‐defined by isotherm models, presenting a maximum adsorption capacity of 23.5 mg g−1 and best fit (R2 = 0.989) with the Freundlich isotherm. The sponge is an efficient material for Cr (VI) removal and provided a promising insight into an adsorption mechanism study.

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“…Citric acid (CA) is a well-known, biodegradable, biocompatible, and natural poly(carboxylic acid) with three carboxylic acid groups and a hydroxyl group. The carboxylic acid groups can form ester bonds with the accessible hydroxyls of cellulose [ 8 ] and starch [ 9 ] in a heterogeneous or homogeneous reaction, respectively. The crucial step in the reaction is the formation of the anhydride of citric acid [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Heating and Citric Acid on the Performance of Cellulose Nanocrystal Thin Films

2023

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Cellulose nanocrystals (CNCs) were extracted from bleached cotton by sulfuric acid hydrolysis. Thin films were prepared from the aqueous suspension of CNCs by casting and evaporation with 15% glycerol as a plasticizer. Our research aimed to create stable films resistant to water. The structure and the interactions of the films were modified by short (10 min) heating at different temperatures (100, 140, and 160 °C) and by adding different amounts of citric acid (0, 10, 20, and 30%). Various analytical methods were used to determine the structure, surface properties, and mechanical properties. The interaction of composite films with water and water vapor was also investigated. Heat treatment did not significantly affect the film properties. Citric acid, without heat treatment, acted as a plasticizer. It promoted the disintegration of films in water, increased water vapor sorption, and reduced tensile strength, resulting in flexible and easy-to-handle films. The combination of heat treatment and citric acid resulted in stable liquid-water-resistant films with excellent mechanical properties. A minimum heating temperature of 120 °C and a citric acid concentration of 20% were required to obtain a stable CNC film structure resistant to liquid water.

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Crosslinked bacterial cellulose hydrogels for biomedical applications

Cited by 34 publications

References 42 publications

Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications

Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications

Bacterial cellulose‐modified castor oil‐based polyurethane sponge for hexavalent chromium removal

Effect of Heating and Citric Acid on the Performance of Cellulose Nanocrystal Thin Films

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