Crosslinking Biopolymers for Advanced Drug Delivery and Tissue Engineering Applications

Thakur, Goutam; Rodrigues, Fiona Concy; Singh, Krizma

doi:10.1007/978-981-13-0950-2_11

Cited by 45 publications

(36 citation statements)

References 94 publications

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“…However, physical methods have limited applicability due to their longer processing times and weak crosslinking abilities, enzymatic methods suffer lack of specificity as biopolymers show significant alterations into their composition owing to the seasonal changes. 21 In spite of being potential cross-linkers such as glutaraldehyde, formaldehyde, methyl glyoxal, bis-acrylamide, and epoxy-based compounds, their degradation products have been found to be cytotoxic. [22][23][24][25][26][27][28] Thus, developing a chemically benign yet a sustainable cross-linked product has become one of the top priorities for tissue engineering researchers.…”

Section: Introductionmentioning

confidence: 99%

A facile chemical cross-linking approach toward the fabrication of a sustainable porous ulvan scaffold

Gajaria

Bhatt

Khandelwal

et al. 2020

Journal of Bioactive and Compatible Polymers

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Ulvans represent one of the most abundant marine-derived macromolecular sulfated polysaccharides accounting for numerous biological applications including in one of the fastest growing field of biomedical sciences. Tissue engineering based on biologically inspired and naturally derived polymers has been one of the prime focuses of regenerative medicine. The present investigation is intended to explore an ionic cross-linking approach at higher pH lead by the calcium ions for casting cell growth promoting scaffolds out of the raw ulvan. The characterization studies using attenuated total reflectance infrared spectroscopy represent specific absorptions at 2950, 980, and 600 cm−1, whereas the x-ray diffraction showed a total absence of major crystalline peaks presenting significant shift to an amorphous state. The 1H nuclear magnetic resonance study revealed functional group modifications in the backbone that might be potentially derived from calcium interactions with glucurorhamnose 3-sulfate and iduronorhamnose 3-sulfate. The atomic force microscopy together with field emission scanning electron microscopy and energy dispersive x-ray spectroscopy mapping revealed the resultant surface changes, whereas confocal microscopy z-stacking showed the cell proliferative activity as evident by the attainment of complete morphology. The combined chemical and biological response of the scaffold makes it a well suitable support for its cell culture and tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

A facile chemical cross-linking approach toward the fabrication of a sustainable porous ulvan scaffold

Gajaria

Bhatt

Khandelwal

et al. 2020

Journal of Bioactive and Compatible Polymers

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“…Crosslinking is the most common approach to modifying polymeric materials. Three types of cross-linking can be classified: enzymatic, physical, and chemical cross-linking [ 206 , 207 , 208 ] ( Figure 12 ).…”

Section: Cross-linkingmentioning

confidence: 99%

“…The modification and crosslinking of polymers and biopolymers using enzymes has captured high interest among research groups [ 207 ]. Reactions with enzymes are characterized by high specificity, lack of side products, and low energy demand.…”

Section: Cross-linkingmentioning

confidence: 99%

“…A physical cross-linking modification usually leads to the change of physico-chemical properties of the polymer through the action of physical factors. This kind of cross-linking includes different techniques, e.g., gamma radiation, laser treatment, UV irradiation, dehydrothermal treatment [ 206 , 207 , 208 ]. Physical modification is a simpler and cheaper method compared to other processes of polymer modification [ 211 ].…”

Section: Cross-linkingmentioning

confidence: 99%

“…Physical modification is a simpler and cheaper method compared to other processes of polymer modification [ 211 ]. Chemical cross-linking is the process used to covalently bridge polymeric chains to improve polymer properties [ 207 , 212 ] The chemical-cross-linking method is considered to be the most effective and predictable [ 205 ]. It provides for formation of very strong bonds.…”

Section: Cross-linkingmentioning

confidence: 99%

See 2 more Smart Citations

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Grabska-Zielińska

Sionkowska

2021

Materials

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This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

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Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing

Pourshahrestani

Zeimaran

Kadri

et al. 2020

Adv Healthcare Materials

270

181

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Broad interest in developing new hemostatic technologies arises from unmet needs in mitigating uncontrolled hemorrhage in emergency, surgical, and battlefield settings. Although a variety of hemostats, sealants, and adhesives are available, development of ideal hemostatic compositions that offer a range of remarkable properties including capability to effectively and immediately manage bleeding, excellent mechanical properties, biocompatibility, biodegradability, antibacterial effect, and strong tissue adhesion properties, under wet and dynamic conditions, still remains a challenge. Benefiting from tunable mechanical properties, high porosity, biocompatibility, injectability and ease of handling, polymeric hydrogels with outstanding hemostatic properties have been receiving increasing attention over the past several years. In this review, after shedding light on hemostasis and wound healing processes, the most recent progresses in hydrogel systems engineered from natural and synthetic polymers for hemostatic applications are discussed based on a comprehensive literature review. Most studies described used in vivo models with accessible and compressible wounds to assess the hemostatic performance of hydrogels. The challenges that need to be tackled to accelerate the translation of these novel hemostatic hydrogel systems to clinical practice are emphasized and future directions for research in the field are presented.

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Crosslinking Biopolymers for Advanced Drug Delivery and Tissue Engineering Applications

Cited by 45 publications

References 94 publications

A facile chemical cross-linking approach toward the fabrication of a sustainable porous ulvan scaffold

A facile chemical cross-linking approach toward the fabrication of a sustainable porous ulvan scaffold

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing

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