Crosslinking of fibrinogen and fibronectin by free radicals: A possible initial step in adhesion formation in osteoarthritis of the temporomandibular joint

Dijkgraaf, Leonore C; Zardeneta, Gustavo; Cordewener, F. W.; Liem, Rsb; Schmitz, John P.; Bont, Lambert G.M. de; Milam, Stephen B.

doi:10.1053/joms.2003.50047

Cited by 44 publications

(21 citation statements)

References 32 publications

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“…Excessive and repetitive mechanical stress has been implicated [19•]. Inflammatory mediators and waste products may play a role in DJD [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. Inflammatory states cause changes in the viscosity of synovial fluid, which changes its ability to nourish the articular cartilage, thus changing cartilage metabolism.…”

Section: The Arthritidesmentioning

confidence: 99%

Temporomandibular joint pain and dysfunction

Herb

Cho

Stiles

2006

Current Science Inc

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Pain caused by temporomandibular disorders originates from either muscular or articular conditions, or both. Distinguishing the precise source of the pain is a significant diagnostic challenge to clinicians, and effective management hinges on establishing a correct diagnosis. This paper examines terminology and regional anatomy as it pertains to functional and dysfunctional states of the temporomandibular joint and muscles of mastication. A review of the pathophysiology of the most common disorders is provided. Trends in evaluation, diagnosis, treatment, and research are presented.

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Section: The Arthritidesmentioning

confidence: 99%

Temporomandibular joint pain and dysfunction

Herb

Cho

Stiles

2006

Current Science Inc

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“…The bacterial staining showed that the ROS was largely distinct from the bacteria and from features of the barnacle. We hypothesize that these ROS at the cuticle layers also contribute to oxidative crosslinking (Okay et al, 1995;Dijkgraaf et al, 2003;Lattuada et al, 2013), as seen in other crustaceans (Willis, 1999;Glazer et al, 2013), and are critical to cuticle development and hardening, as seen in insects (Hopkins and Kramer, 1992;Suderman et al, 2006;Andersen, 2010). Further work is needed to define the specific ROS present and show the extent of their presence during development as only post-metamorphic juveniles were examined.…”

Section: Discussionmentioning

confidence: 99%

Barnacle biology before, during and after settlement and metamorphosis: a study of the interface

Essock‐Burns

Gohad

Orihuela

et al. 2016

Journal of Experimental Biology

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Mobile barnacle cypris larvae settle and metamorphose, transitioning to sessile juveniles with morphology and growth similar to that of adults. Because biofilms exist on immersed surfaces on which they attach, barnacles must interact with bacteria during initial attachment and subsequent growth. The objective of this study was to characterize the developing interface of the barnacle and substratum during this key developmental transition to inform potential mechanisms that promote attachment. The interface was characterized using confocal microscopy and fluorescent dyes to identify morphological and chemical changes to the interface and the status of bacteria present as a function of barnacle developmental stage. Staining revealed patchy material containing proteins and nucleic acids, reactive oxygen species amidst developing cuticle, and changes in bacteria viability at the developing interface. We found that as barnacles metamorphose from the cyprid to juvenile stage, proteinaceous materials with the appearance of coagulated liquid were released into and remained at the interface. It stained positive for proteins, including phosphoprotein, as well as nucleic acids. Regions of the developing cuticle and the patchy material itself stained for reactive oxygen species. Bacteria were absent until the cyprid was firmly attached, but populations died as barnacle development progressed. The oxidative environment may contribute to the cytotoxicity observed for bacteria and has the potential for oxidative crosslinking of cuticle and proteinaceous materials at the interface.

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“…Excessive and repetitive mechanical stress has been implicated [19]. Inflammatory mediators and waste products may play a role in DJD [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. Inflammatory states cause changes in the viscosity of synovial fluid, which changes its ability to nourish the articular cartilage, thus changing cartilage metabolism.…”

Section: The Artritidesmentioning

confidence: 99%