Crosslinking of Polyvinyl Alcohol (PVA) and Effect of Crosslinker Shape (Aliphatic and Aromatic) Thereof

Sonker, Amit Kumar; Rathore, Kalpana; Nagarale, Rajaram K.; Verma, Vivek

doi:10.1007/s10924-017-1077-3

Cited by 124 publications

(93 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After crosslinking, an increase in the number of covalent bonds and hydrogen bonding between the polymer chains occurred, making them more thermally stable. This finding agrees with results from other authors that crosslinked PVA with AA and GA [ 28 ]. This thermal effect was more relevant for the PGAH sample, showing 39.7% of weight loss.…”

Section: Resultssupporting

confidence: 94%

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

et al. 2020

View full text Add to dashboard Cite

A series of hydrogels with a specific release profile of linezolid was successfully synthesized. The hydrogels were synthesized by cross-linking polyvinyl alcohol (PVA) and aliphatic dicarboxylic acids, which include succinic acid (SA), glutaric acid (GA), and adipic acid (AA). The three crosslinked hydrogels were prepared by esterification and characterized by equilibrium swelling ratio, infrared spectroscopy, thermogravimetric analysis, mechanical properties, and scanning electron microscopy. The release kinetics studies of the linezolid from prepared hydrogels were investigated by cumulative drug release and quantified by chromatographic techniques. Mathematical models were carried out to understand the behavior of the linezolid release. These data revealed that the sustained release of linezolid depends on the aliphatic dicarboxylic acid chain length, their polarity, as well as the hydrogel crosslinking degree and mechanical properties. The in vitro antibacterial assay of hydrogel formulations was assessed in an Enterococcus faecium bacterial strain, showing a significant activity over time. The antibacterial results were consistent with cumulative release assays. Thus, these results demonstrated that the aliphatic dicarboxylic acids used as crosslinkers in the PVA hydrogels were a determining factor in the antibiotic release profile.

show abstract

Section: Resultssupporting

confidence: 94%

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Peaks at 1329, 1086 and 1043 cm −1 can be associated with the deformation vibration of C–O groups [ 38 ]. It is expected that crosslinking of PVA by GD decreases the number of hydroxyl groups by forming crosslink ester bonds in the PVA, with variations in intensity for −OH and −C = O (ester) group [ 39 ]. Disappearance of peaks at 1576 and 1540 cm −1 , due to deformation of CH bonds, can be an indication of possible crosslinking reaction.…”

Section: Resultsmentioning

confidence: 99%

Effect of Cellulose Nanocrystals and Lignin Nanoparticles on Mechanical, Antioxidant and Water Vapour Barrier Properties of Glutaraldehyde Crosslinked PVA Films

et al. 2020

View full text Add to dashboard Cite

In this work, PVA nanocomposite films containing cellulose nanocrystals (CNC) and different amounts of lignin nanoparticles (LNP), prepared via a facile solvent cast method, were crosslinked by adding glutaraldehyde (GD). The primary objective was to investigate the effects of crosslinker and bio-based nanofillers loading on thermal, mechanical, antioxidant and water barrier behaviour of PVA nanocomposite films for active food packaging. Thermogravimetric analysis showed improved thermal stability, due to the strong interactions between LNP, CNC and PVA in the presence of GD, while Wide-angle X-ray diffraction results confirmed a negative effect on crystallinity, due to enhanced crosslinking interactions between the nanofillers and PVA matrix. Meanwhile, the tensile strength of PVA-2CNC-1LNP increased from 26 for neat PVA to 35.4 MPa, without sacrificing the ductility, which could be explained by a sacrificial hydrogen bond reinforcing mechanism induced by spherical-like LNP. UV irradiation shielding effect was detected for LNP containing PVA films, also migrating ingredients from PVA nanocomposite films induced radical scavenging activity (RSA) in the produced films in presence of LNP. Furthermore, PVA-CNC-LNP films crosslinked by GD showed marked barrier ability to water vapour.

show abstract

“…In PVA, it can be accomplished via chemical reaction (e.g., free-radical polymerization, chemical reaction of complementary groups, high energy irradiation or enzymatic reaction) or by physical reaction (e.g., ionic interaction, crystallization of the polymeric chain, hydrogen bond, protein interaction or design of graft copolymers) [81]. The most frequent chemical agents or crosslinkers applied to PVA are the dialdehydes, diisocyanates, dicarboxylic, tricarboxylic and boric acids (Table 3) [92]. Even though there are many options, glutaraldehyde (GA) is by far the most common crosslinker used in PVA processing.…”

Section: Poly(vinyl Alcohol)mentioning

confidence: 99%

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

View full text Add to dashboard Cite

Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.

show abstract

Crosslinking of Polyvinyl Alcohol (PVA) and Effect of Crosslinker Shape (Aliphatic and Aromatic) Thereof

Cited by 124 publications

References 41 publications

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

Effect of Cellulose Nanocrystals and Lignin Nanoparticles on Mechanical, Antioxidant and Water Vapour Barrier Properties of Glutaraldehyde Crosslinked PVA Films

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Contact Info

Product

Resources

About