Crosstalk between incretin hormones, Th17 and Treg cells in inflammatory diseases

Silva, Eloisa Martins da; Yariwake, Victor Yuji; Alves, Renan Willian; Araújo, Daniele Ribeiro de; Andrade-Oliveira, Vinícius

doi:10.1016/j.peptides.2022.170834

Cited by 6 publications

(3 citation statements)

References 212 publications

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“…In addition, GLP-1RAs were shown to inhibit inflammatory responses and modulate the immune response, with specific activity on the Treg/Th17 axis [ 38 ]. Furthermore, preclinical evidence suggests that incretins suppress cardiac fibrosis and reduce inflammatory cytokine gene expression in a mouse model of experimental autoimmune myocarditis [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiac Wolframinopathies: A Case Report of Myocarditis and a Literature Review of Cardiac Involvement in Wolfram Syndrome 1

Villatore,

Frontino,

Cascavilla

et al. 2024

JCM

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Purpose: Myocarditis is frequently a sporadic disease, but may also occur in the context of genetic disorders which may increase susceptibility to cardiac inflammation. Cardiac involvement in Wolfram syndrome type 1 (WS1) has been scarcely characterized. To our knowledge, no cases of virus-negative myocarditis have been reported in the WS1 pediatric population. Methods: We report the description of a pediatric case of acute myocarditis in the context of WS1, followed by a literature review of cardiovascular involvement associated with wolframin variants, and discuss potential pathophysiological mechanisms and therapeutic options. Results: A young patient with WS1, treated with insulin and liraglutide, was admitted for acute chest pain. Cardiac magnetic resonance and endomyocardial biopsy were performed to confirm the clinical suspicion of myocarditis. While congenital heart diseases and arrhythmias have been described previously in patients with WS1, this is the first description of virus-negative myocarditis. Conclusions: Myocarditis may represent a possible manifestation of cardiovascular involvement in WS1. Cardiovascular screening may be considered in patients with WS1.

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Section: Discussionmentioning

confidence: 99%

Cardiac Wolframinopathies: A Case Report of Myocarditis and a Literature Review of Cardiac Involvement in Wolfram Syndrome 1

Villatore,

Frontino,

Cascavilla

et al. 2024

JCM

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“…The imbalance between the Treg and Th17 ratio plays a pivotal role in the pathogenesis of a wide a wide array of inflammatory diseases [184], tumors [185], autoimmune disorders [186,187], and metabolic conditions [188][189][190]. A sour understanding of the contributions of IL-17-producing Treg and IL-10-producing Th17 in these diseases continues to expand, their associations with conditions such as inflammatory bowel disease (IBD), cancer, nephritis, autoimmune disorders, and others are gradually being unveiled.…”

Section: The Roles Of Il-17-producing Treg and Il-10-producing Th17 I...mentioning

confidence: 99%

The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

Cui,

Wang,

et al. 2024

Cell Commun Signal

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The changes in T regulatory cell (Treg) and T helper cell (Th) 17 ratios holds paramount importance in ensuring internal homeostasis and disease progression. Recently, novel subsets of Treg and Th17, namely IL-17-producing Treg and IL-10-producing Th17 have been identified. IL-17-producing Treg and IL-10-producing Th17 are widely considered as the intermediates during Treg/Th17 transformation. These “bi-functional” cells exhibit plasticity and have been demonstrated with important roles in multiple physiological functions and disease processes. Yin and Yang represent opposing aspects of phenomena according to the ancient Chinese philosophy “Yin-Yang” theory. Furthermore, Yin can transform into Yang, and vice versa, under specific conditions. This theory has been widely used to describe the contrasting functions of immune cells and molecules. Therefore, immune-activating populations (Th17, M1 macrophage, etc.) and immune overreaction (inflammation, autoimmunity) can be considered Yang, while immunosuppressive populations (Treg, M2 macrophage, etc.) and immunosuppression (tumor, immunodeficiency) can be considered Yin. However, another important connotation of “Yin-Yang” theory, the conversion between Yin and Yang, has been rarely documented in immune studies. The discovery of IL-17-producing Treg and IL-10-producing Th17 enriches the meaning of “Yin-Yang” theory and further promotes the relationship between ancient “Yin-Yang” theory and modern immunology. Besides, illustrating the functions of IL-17-producing Treg and IL-10-producing Th17 and mechanisms governing their differentiation provides valuable insights into the mechanisms underlying the dynamically changing statement of immune statement in health and diseases.

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“…Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine cells that reside within intestine epithelium ( 59 ). Targeting GLP-1 may be an effective therapeutic strategy for Th17/Treg-mediated inflammatory diseases ( 60 ). A clinical research showed that GLP-1 appeared to decrease production of Th17-related cytokines in people with obesity and asthma ( 61 ).…”

Section: Th17 In Endocrine Organsmentioning

confidence: 99%

The role of Th17 cells in endocrine organs: Involvement of the gut, adipose tissue, liver and bone

Wang

Gao

et al. 2023

Front. Immunol.

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T Helper 17 (Th17) cells are adaptive immune cells that play myriad roles in the body. Immune–endocrine interactions are vital in endocrine organs during pathological states. Th17 cells are known to take part in multiple autoimmune diseases over the years. Current evidence has moved from minimal to substantial that Th17 cells are closely related to endocrine organs. Diverse tissue Th17 cells have been discovered within endocrine organs, including gut, adipose tissue, liver and bone, and these cells are modulated by various secretions from endocrine organs. Th17 cells in these endocrine organs are key players in the process of an array of metabolic disorders and inflammatory conditions, including obesity, insulin resistance, nonalcoholic fatty liver disease (NAFLD), primary sclerosing cholangitis (PSC), osteoporosis and inflammatory bowel disease (IBD). We reviewed the pathogenetic or protective functions played by Th17 cells in various endocrine tissues and identified potential regulators for plasticity of it. Furthermore, we discussed the roles of Th17 cells in crosstalk of gut-organs axis.

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Crosstalk between incretin hormones, Th17 and Treg cells in inflammatory diseases

Cited by 6 publications

References 212 publications

Cardiac Wolframinopathies: A Case Report of Myocarditis and a Literature Review of Cardiac Involvement in Wolfram Syndrome 1

Cardiac Wolframinopathies: A Case Report of Myocarditis and a Literature Review of Cardiac Involvement in Wolfram Syndrome 1

The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

The role of Th17 cells in endocrine organs: Involvement of the gut, adipose tissue, liver and bone

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