Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology

Fioravanti, Antonella; Pirtoli, Luigi; Giordano, Antonio; Dotta, Francesco

doi:10.3390/ijms21041270

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…These mechanisms of regulation of gene expression modulate metabolic pathways and induce physiological responses, but also activate pathophysiological signaling pathways [ 41 , 43 ]. In fact, recent studies provide evidence that shows crosstalk between miRNAs and components of redox signaling through the modulation of genes related to the formation and removal of ROS [ 44 ]. In this context, scientific reports provide evidence that supports the role of miRNAs as potential therapeutic targets in acute and chronic diseases through modulation of signaling pathways, autophagy, mitochondrial metabolism, glycolysis, and redox, among others [ 45 , 46 , 47 ].…”

Section: Evs In Kidneysmentioning

confidence: 99%

Extracellular Vesicles in Redox Signaling and Metabolic Regulation in Chronic Kidney Disease

et al. 2022

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Chronic kidney disease (CKD) is a world health problem increasing dramatically. The onset of CKD is driven by several mechanisms; among them, metabolic reprogramming and changes in redox signaling play critical roles in the advancement of inflammation and the subsequent fibrosis, common pathologies observed in all forms of CKD. Extracellular vesicles (EVs) are cell-derived membrane packages strongly associated with cell-cell communication since they transfer several biomolecules that serve as mediators in redox signaling and metabolic reprogramming in the recipient cells. Recent studies suggest that EVs, especially exosomes, the smallest subtype of EVs, play a fundamental role in spreading renal injury in CKD. Therefore, this review summarizes the current information about EVs and their cargos’ participation in metabolic reprogramming and mitochondrial impairment in CKD and their role in redox signaling changes. Finally, we analyze the effects of these EV-induced changes in the amplification of inflammatory and fibrotic processes in the progression of CKD. Furthermore, the data suggest that the identification of the signaling pathways involved in the release of EVs and their cargo under pathological renal conditions can allow the identification of new possible targets of injury spread, with the goal of preventing CKD progression.

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Section: Evs In Kidneysmentioning

confidence: 99%

Extracellular Vesicles in Redox Signaling and Metabolic Regulation in Chronic Kidney Disease

et al. 2022

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“…MicroRNAs are single-stranded ncRNAs (~21-24 nt) that regulate gene expression at the post-transcriptional level by silencing specific target RNAs or by targeting regulatory RNAs such as lncRNAs [22]. Each miRNA can target hundreds or thousands of mRNAs, and their deregulation is associated with an increasing number of human diseases [24][25][26], including several pregnancy-associated disorders [14,27] namely, spontaneous preterm birth [28], small-for-gestational-age (SGA) births [29], ectopic pregnancy [30], GDM [31], and PE [32]. PIWI-interacting RNAs (piRNAs) are another class of short ncRNAs (26-31 nt) involved in the differentiation of embryonic stem cells and in early embryonic development.…”

Section: Ncrnas As Potential Biomarkersmentioning

confidence: 99%

Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications

et al. 2021

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In the era of personalized medicine, fetal sex-specific research is of utmost importance for comprehending the mechanisms governing pregnancy and pregnancy-related complications. In recent times, noncoding RNAs (ncRNAs) have gained increasing attention as critical players in gene regulation and disease pathogenesis, and as candidate biomarkers in human diseases as well. Different types of ncRNAs, including microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), participate in every step of pregnancy progression, although studies taking into consideration fetal sex as a central variable are still limited. To date, most of the available data have been obtained investigating sex-specific placental miRNA expression. Several studies revealed that miRNAs regulate the (patho)-physiological processes in a sexually dimorphic manner, ensuring normal fetal development, successful pregnancy, and susceptibility to diseases. Moreover, the observation that ncRNA profiles differ according to cells, tissues, and developmental stages of pregnancy, along with the complex interactions among different types of ncRNAs in regulating gene expression, strongly indicates that more studies are needed to understand the role of sex-specific ncRNA in pregnancy and associated disorders.

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“…Human diseases are generally very complex, and the deregulation of multiple genes is often the crucial step in the transformation of normal into pathological cell. Thus, the modulation of a relatively small number of miRNAs may amplify protective effects in the redox balance, influencing hundreds of transcripts, and making the crosstalk between different cellular pathways possible [74]. In this optic, the multi-targeting nature of miRNAs renders them very suitable as a therapeutic tool [75].…”

Section: Epigenetic Mirna-based Approachmentioning

confidence: 99%

Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here

2020

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Oxidative stress (OxS) is one of the main processes related to aging and a common denominator of many different chronic/degenerative diseases (e.g., cardiovascular and neurodegenerative conditions and cancer). Thus, its potential modulation by supplementation/pharmacological therapy caused a lot of interest. However, these expectations have been mitigated by the obtainment of controversial results (beneficial, null, or adverse effects) following antioxidant interventions. Here, we discuss the current understanding of OxS assessment in health and disease, challenges and the potential of its evaluation in clinical practice, and available and future development for supplementation and pharmacologic strategies targeting OxS.

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Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology

Abstract: MicroRNAs (miRNA), are short regulatory RNA molecules that regulate gene expression by binding specific sequences within target messenger RNA (mRNA) [...]

Cited by 11 publications

References 14 publications

Extracellular Vesicles in Redox Signaling and Metabolic Regulation in Chronic Kidney Disease

Extracellular Vesicles in Redox Signaling and Metabolic Regulation in Chronic Kidney Disease

Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications

Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here

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