Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis

Khalmuratova, Roza; Shin, Hyun–Woo

doi:10.21053/ceo.2020.00416

Cited by 17 publications

(13 citation statements)

References 78 publications

(95 reference statements)

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“…Generally, NECRSwNP is regarded as an extrinsic form of CRS, since its inflammation originates from external stimuli such as bacteria and allergens, rather than intrinsic mucosal abnormalities [ 27 ]. Thus, NECRSwNP usually shows enhanced epithelial alterations and more localized maxillary involvement than ECRSwNP [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Collectively, the increased heterogeneity in immune status may be associated with more severe disease expression, remodeling, and poor response to corticosteroids in patients with ECRSwNP and moderate-to-severe OSA. Generally, NECRSwNP is regarded as an extrinsic form of CRS, since its inflammation originates from external stimuli such as bacteria and allergens, rather than intrinsic mucosal abnormalities [27]. Thus, NECRSwNP usually shows enhanced epithelial alterations and more localized maxillary involvement than ECRSwNP [28,29].…”

Section: Tgf-β1mentioning

confidence: 99%

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Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps

Kim

Lee

Park

et al. 2021

Clin Exp Otorhinolaryngol

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Objective: Chronic rhinosinusitis (CRS) with nasal polyp (wNP) is a more severe inflammatory form of CRS that often coexists with obstructive sleep apnea (OSA). However, little is known the relationship between OSA and immunologic profile on patients with CRSwNP. We aimed to investigate the immune profile of patients with CRSwNP according to OSA severity.Methods: This study included 63 patients with CRSwNP and nine control subjects. Protein levels of inflammatory mediators were determined using multiplex immunoassay. All patients underwent standard polysomnography.Results: We found that, in patients with eosinophilic CRSwNP (ECRSwNP), IL-6 and CXCL-1 (type 1 immune-related markers) were upregulated in cases of moderate-to-severe OSA. Additionally, IL-4, IL-13, CCL-11, CCL-24 (type 2 immune-related markers), and IL-17A (type 3 immune-related marker) were increased in patients with moderate-to-severe OSA. Though there were no significant differences in type 1, 2, or 3 immune-related markers among patients with non-eosinophilic CRSwNP (NECRSwNP) according to the severity of OSA, TGF-

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Section: Discussionmentioning

confidence: 99%

Section: Tgf-β1mentioning

confidence: 99%

Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps

Kim

Lee

Park

et al. 2021

Clin Exp Otorhinolaryngol

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“…More than one million different endophytic fungal strains have been reported to inhabit about 300,000 plant species [6]. Most fungal endophytes that have been reported belong to the Basidiomycota or Ascomycota [7,8]. Fungal endophytes function as stimulants of plant growth by synthesising phytohormones, enhancing nutrient accessibility by mobilising soil insoluble nutrients, and by protecting host plants against abiotic and biotic stress [9,10].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Effect and Mode of Action of Secondary Metabolites from Fungal Endophyte Associated with Aloe ferox Mill

Maliehe

Mbambo

Nqotheni

et al. 2022

Microbiology Research

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The constant increase in drug resistance, occurrence of incurable diseases and high medical costs, have necessitated bio-prospecting of fungi as alternative sources of therapeutic compounds. This study aimed at assessing the antibacterial effect and mode of action of secondary metabolites from fungal endophyte associated with Aloe ferox Mill. Endophytic fungus was isolated from the gel of A. ferox and identified by internal transcribed spacer (ITS) rRNA gene sequence analysis. The targets of antibacterial activity were assessed based on minimum inhibitory concentration (MIC) and the effect of the extract on respiratory chain dehydrogenase (RCD) and membrane integrity. Fourier transform-infrared spectrophotometer (FTIR) was employed to ascertain functional groups. The fungus with the most promising antibiotic-production was identified as Aspergillus welwitschiae MK450668.1. Its extract exhibited antibacterial activity with the MIC values of 0.5 and 1 mg/mL against Staphylococcus aureus (ATCC 25925) and Escherichia coli (ATCC 25922). It demonstrated the inhibitory effect on the RCD activity and destruction of membrane integrity on the test bacteria. FTIR spectrum revealed hydroxyl, amine and alkene groups. A. welwitschiae MK450668.1 serves as a potential source of effective compounds to combat the challenge of drug resistance.

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“…PBMP contains both phosphomonoester groups for calcium binding and butyl groups for hydrophobic PLGA binding, respectively, and can be coated on the hydrophobic surface of PLGA microparticles to introduce an adhesive property on calcium-rich tissues. We selected dexamethasone (Dex) as a model corticoid drug, which can reduce the inflammatory sinonasal mucosa [ 19 ] and promote wound repair following the surgical procedure [ 20 ]. We intended to maintain the Dex concentration for a longer duration only near the exposed bones after the surgery through sustained Dex release from the PLGA/PBMP particles, which have a specific binding affinity to the calcium-rich tissues ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Alleviation of Surgery-Induced Osteitis in Sinonasal Cavity by Dexamethasone-Loaded Poly(lactic-co-glycolic acid) (PLGA) Microparticles with Strong Calcium-Binding Affinity

et al. 2022

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For the treatment of sinus surgery-induced osteitis in chronic rhinosinusitis (CRS), oral or intranasal administration of corticoids is generally used, although it has critical limitations and unavoidable side effects. To overcome these limitations, we designed dexamethasone (Dex)-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles with bone-specific binding affinity, which could release the encapsulated Dex in a sustained manner on the exposed bone after the surgical wound in the nasal cavity. In a previous report, we prepared poly(butyl methacrylate-co-methacryloyloxyethyl phosphate) (PBMP) with both calcium-binding phosphomonoester groups and PLGA-binding butyl groups to introduce strong calcium-binding property to PLGA particles. In this study, after successful encapsulation of Dex in the PBMP-coated PLGA particles, we applied the Dex-PLGA/PBMP to the treatment of post-operative osteitis in the sinonasal cavity. The Dex-PLGA/PBMP showed more than 5-times higher binding affinity to the hydroxyapatite (HA) surface compared to the non-coated PLGA particles, without altering the morphology and encapsulation efficiency. After establishing the neo-osteogenesis mouse model by mechanical injury of the nasal mucosa, the activity of intranasally administered Dex-PLGA/PBMP was examined to inhibit the formation of undesirable new woven bone during the wound healing process. In addition, significantly lower osteocalcin activity was observed in the group treated with Dex-PLGA/PBMP, indicating decreased activation of osteoblasts. Overall, these results demonstrate that the PLGA/PBMP microparticle strategy has great potential for the treatment of CRS-related osteitis by localized corticoid delivery on the exposed bones with minimal side effects.

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Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis

Cited by 17 publications

References 78 publications

Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps

Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps

Antibacterial Effect and Mode of Action of Secondary Metabolites from Fungal Endophyte Associated with Aloe ferox Mill

Alleviation of Surgery-Induced Osteitis in Sinonasal Cavity by Dexamethasone-Loaded Poly(lactic-co-glycolic acid) (PLGA) Microparticles with Strong Calcium-Binding Affinity

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