2022
DOI: 10.3389/fendo.2022.836344
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Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg

Abstract: The regulation of insulin secretion is under control of a complex inter-organ/cells crosstalk involving various metabolites and/or physical connections. In this review, we try to illustrate with current knowledge how β-cells communicate with other cell types and organs in physiological and pathological contexts. Moreover, this review will provide a better understanding of the microenvironment and of the context in which β-cells exist and how this can influence their survival and function. Recent studies showed… Show more

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Cited by 21 publications
(8 citation statements)
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References 153 publications
(194 reference statements)
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“…Dysfunction of the islet is clinically important in pancreatitis, type 1 and 2 diabetes mellitus, and cancer; therefore, tight regulation of the islet microenvironment is essential for the intact integrity and function of the islet. Cells that live in the islet microenvironment communicate with each other by secreting soluble factors or extracellular vesicles (EVs), and by forming GAP junctions or nanotubes between adjacent cells [34]. The secretory activity of β cells leads to the proliferation and migration of nearby cells, including endothelial cells, pericytes, and pancreatic stellate cells, production of ECM proteins, and macrophage infiltration [21,35].…”
Section: Discussionmentioning
confidence: 99%
“…Dysfunction of the islet is clinically important in pancreatitis, type 1 and 2 diabetes mellitus, and cancer; therefore, tight regulation of the islet microenvironment is essential for the intact integrity and function of the islet. Cells that live in the islet microenvironment communicate with each other by secreting soluble factors or extracellular vesicles (EVs), and by forming GAP junctions or nanotubes between adjacent cells [34]. The secretory activity of β cells leads to the proliferation and migration of nearby cells, including endothelial cells, pericytes, and pancreatic stellate cells, production of ECM proteins, and macrophage infiltration [21,35].…”
Section: Discussionmentioning
confidence: 99%
“…Within the neural network, an individual β cell is connected to other β cells, which mediates insulin secretion. β cells can be characterized as either “Leader cells” or “Follower cells” based on their functional characteristics [ 14 ]. Leader β cells possess pacemaker properties, allowing them to respond to glucose and synchronize communication patterns with follower cells.…”
Section: Pancreatic Neuronal Networkmentioning
confidence: 99%
“…Rather, non-b endocrine cells are a byproduct of the differentiations. Since crosstalk amongst endocrine cell types plays an important role in maintenance of blood glucose homeostasis (74), generating appropriate ratios and organization of endocrine cells as found in healthy islets should improve functionality, which is part of the promise of using organoids rather than hPSC derived b-like differentiations. One breakthrough example of this comes from the identification of a progenitor population in the adult murine islet which can be isolated by the surface marker Procr (69).…”
Section: Organoidsmentioning
confidence: 99%