Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis

Li, Liyi; Luo, Yue; Lu, Mingdong; Xu, Xiaorong; Lin, Hai-duo; Zheng, Zhiqiang

doi:10.1186/s12957-015-0454-4

Cited by 40 publications

(31 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our studies have demonstrated that purified sulforaphane is able to overcome the pronounced therapy resistance of PDA in vitro and in vivo [7,8], and similar results have been obtained in experimental models of prostate and breast cancer [8][9][10][11]. Epidemiological studies have suggested that the frequent intake of cruciferous vegetables might be inversely associated with the risk of developing pancreatic cancer [12][13][14][15][16], as well as cancer of the breast, kidney, bladder and prostate [17][18][19][20][21][22]. A Canadian study observed a significantly decreased risk of extra-prostatic manifestations of stage III and IV prostate cancer when men frequently consumed broccoli and cauliflower [17].…”

Section: Introductionsupporting

confidence: 82%

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study

Lozanovski¹,

Polychronidis²,

Groß

et al. 2019

Invest New Drugs

View full text Add to dashboard Cite

Pancreatic ductal adenocarcinoma is a highly aggressive malignancy with short survival and limited therapeutic options. Broccoli sulforaphane is a promising new treatment due to the results of recent epidemiological, experimental and patient studies. Upon approval from the ethics committee and registration at ClinicalTrials.gov, 40 patients with palliative chemotherapy were placed into a placebo and treatment group in an unblinded fashion. Fifteen capsules with pulverized broccoli sprouts containing 90 mg/508 μmol sulforaphane and 180 mg/411 μmol glucoraphanin or methylcellulose were administered daily for up to 1 year. Twenty-nine patients were included in the treatment group and 11 patients were in the placebo group; these patients were followed for up to 1 year. The patient characteristics, overall survival and feasibility were assessed. Compared to those of the placebo group, the mean death rate was lower in the treatment group during the first 6 months after intake (day 30: 0%/18%, day 90: 0%/25%, and day 180: 25%/43%), and Kaplan-Meier analysis revealed a higher survival rate. There was a high drop-out rate (72% in the treatment group and 55% in the placebo group) after 1 year. We concluded from the Karnofsky index that the broccoli sprouts did not impact patient's self-care and overall abilities severely. The intake of 15 capsules daily was difficult for some patients, and the broccoli sprouts sometimes increased digestive problems, nausea and emesis. We did not obtain statistically significant results (p = 0.291 for the endpoint at day 180), but the knowledge about the feasibility is the basis for the development of new sulforaphane drugs.

show abstract

Section: Introductionsupporting

confidence: 82%

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study

Lozanovski¹,

Polychronidis²,

Groß

et al. 2019

Invest New Drugs

View full text Add to dashboard Cite

show abstract

“…Following this line of research, pancreatic cancer is responsible for 4.5% of the total number of deaths in 2018 [112]. In 2015, Li [103] showed that cruciferous plant consumption might be inversely associated with pancreatic cancer risk. Nevertheless, given that the number of studies included in this research is scarce, further evidence needs to be included in future meta-analyses.…”

Section: Functionality: What Has Been Demonstrated and What Remains Tmentioning

confidence: 99%

Functional Ingredients From Brassicaceae Species: Overview and Perspectives

Ramírez

Abellán-Victorio

Beretta

et al. 2020

IJMS

103

View full text Add to dashboard Cite

Brassicaceae vegetables are important crops consumed worldwide due to their unique flavor, and for their broadly recognized functional properties, which are directly related to their phytochemical composition. Isothiocyanates (ITC) are the most characteristic compounds, considered responsible for their pungent taste. Besides ITC, these vegetables are also rich in carotenoids, phenolics, minerals, and vitamins. Consequently, Brassica’s phytochemical profile makes them an ideal natural source for improving the nutritional quality of manufactured foods. In this sense, the inclusion of functional ingredients into food matrices are of growing interest. In the present work, Brassicaceae ingredients, functionality, and future perspectives are reviewed.

show abstract

“…Isothiocyanates are breakdown products of glucosinolates, and sulforaphane is produced from the precursor glucoraphanin, a major glucosinolate found in broccoli . A meta‐analysis of cohort and case control studies has suggested cruciferous vegetable intake may reduce the risk of breast and pancreatic cancer . Epidemiological data has been useful in highlighting the potential anti‐carcinogenic effect of cruciferous vegetables; however, identifying the most potent anti‐carcinogenic compounds within these foods is more difficult.…”

Section: Isothiocyanates – Sulforaphanementioning

confidence: 99%

Targeting cancer stem‐like cells using dietary‐derived agents – Where are we now?

Khan

Karmokar

Howells

et al. 2016

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Diet has been linked to an overwhelming proportion of cancers. Current chemotherapy and targeted therapies are limited by toxicity and the development of resistance against these treatments results in cancer recurrence or progression. In vitro evidence indicates that a number of dietary-derived agents have activity against a highly tumorigenic, chemoradiotherapy resistant population of cells within a tumour. This population is associated with cancer recurrence and is therefore clinically significant. Targeting this subpopulation, termed cancer stem-like cells with dietary-derived agents provides a potentially low toxicity strategy to enhance current treatment regimens. In addition, dietary-derived compounds also provide a novel approach to cancer prevention strategies. This review focusses on selected diet-derived agents that have been shown to specifically target cancer stem-like cells using in vivo models, or in clinical trials. Furthermore, the potential limitations of these studies are discussed, and areas of research that need to be addressed to allow successful translation of dietary-derived agents to the clinical arena are highlighted.

show abstract

Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis

Cited by 40 publications

References 39 publications

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study

Functional Ingredients From Brassicaceae Species: Overview and Perspectives

Targeting cancer stem‐like cells using dietary‐derived agents – Where are we now?

Contact Info

Product

Resources

About