Crude oil exposure results in oxidative stress-mediated dysfunctional development and reproduction in the copepod Tigriopus japonicus and modulates expression of cytochrome P450 (CYP) genes

Developmental retardation, reduced fecundity, and modulated expression of the defensome in the intertidal copepod Tigriopus japonicus exposed to BDE-47 and PFOS

“…The CYP proteins are a large and diverse family of enzymes associated with detoxification mechanisms of xenobiotic chemicals in diverse organisms (Guengerich, 2008). Dose-dependent expression of these three CYP genes in T. japonicus was confirmed to be a good indicator of response to water accommodated fractions (WAFs) of oil spillage (Han et al, 2014a). In response to BDE-47 and PFOS exposure, Tj-CYP3027C2 and Tj-CYP3024A2 genes were slightly induced up to 2-fold compared to the control (P < 0.05).…”

Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms

“…Cumulatively, these data indicate that rotifers have great potential as bioindicator species to study xenobiotic metabolism and the effects of xenobiotics on detoxification and oxidative stress Yang et al, 2013aYang et al, , 2013bYang et al, , 2013c in AOP development. The potential of rotifers as an indicator species was also demonstrated in various studies in which they were exposed to gamma-radiation, pharmaceuticals, metal, and endocrine disruptors Han et al, 2014). Thus, rotifers may help the development of an AOP that links the molecular response to effects on the individual and population levels in ERA.…”

Dose- and time-dependent expression of aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (ARNT) in PCB-, B[a]P-, and TBT-exposed intertidal copepod Tigriopus japonicus

“…2 and 3) implying the possibility of a basic system for a putative AhR-CYP signaling pathway. T. japonicus has several specific CYP genes that are substantially expressed in response to WAFs from crude oil (Han et al, 2014), indicating that T. japonicus has key factors for a putative AhR-CYP signaling pathway to modulate the AhR, ARNT, and CYP genes in response to EDCs exposure.…”

“…Several key CYP genes involved in the detoxification mechanism are susceptible to B[a]P exposure in B. koreanus. In the copepod Tigriopus japonicus, the expression profiles of 52 CYP genes were examined in response to exposure to the water-accommodated fractions (WAFs) from crude oil (Han et al, 2014). After WAF exposure, three T. japonicus http://dx.doi.org/10.1016/j.chemosphere.2014.07.099 0045-6535/Ó 2014 Elsevier Ltd. All rights reserved.…”