Crude saponins improve the immune response to an oral plant-made measles vaccine

Pickering, Raelene; Smith, Sarah D.; Strugnell, Richard A.; Wesselingh, Steven Lodewyk; Webster, Diane

doi:10.1016/j.vaccine.2005.07.097

Cited by 34 publications

(12 citation statements)

References 37 publications

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“…Saponins are well studied as adjuvants on animal immune responses and enhance cellmediated and antibody responses [26]. In addition, they are also effective via oral use, although saponins do not enter the intestinal epithelial barrier [27]. In trout fed SBM, saponins can enhance the specific plasma antibody responses after an intraperitoneal injection with formalin fixed Aeromonas salmonicida bacterin [28].…”

Section: Discussionmentioning

confidence: 99%

Soybean meal induces intestinal inflammation in common carp (Cyprinus carpio L.)

Urán

Gonçalves

Taverne-Thiele

et al. 2008

Fish & Shellfish Immunology

292

142

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Section: Discussionmentioning

confidence: 99%

Soybean meal induces intestinal inflammation in common carp (Cyprinus carpio L.)

Urán

Gonçalves

Taverne-Thiele

et al. 2008

Fish & Shellfish Immunology

292

142

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“…Although CTB may not be highly toxic, there may be some clinical side effects. A safer adjuvant might be developed from plants that produce compounds such as saponin 22 and it may be feasible to develop adjuvant-free oral vaccine from plants. Further animal study is necessary to determine the effectiveness of adjuvant-free Aβ rice for AD.…”

Section: Resultsmentioning

confidence: 99%

Transgenic Rice Expressing Amyloid β-peptide for Oral Immunization

Yoshida¹,

Kimura²,

Koike³

et al. 2011

Int. J. Biol. Sci.

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Various vaccine therapies for Alzheimer's disease (AD) have been investigated. Here we report transgenic rice expressing amyloid β-peptide (Aβ). The Aβ42 gene fused with a green fluorescent protein gene was introduced into rice using the Agrobacterium method. When transgenic brown rice expressing Aβ was orally administered to mice, serum anti-Aβ antibody titers were elevated. The same results were observed when mice were fed boiled, transgenic brown rice. The results indicate that an edible vaccine against AD using rice may be feasible. A vaccine derived from rice would be far cheaper than existing medical vaccines.

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“…Measles antigens expressed in plants have been shown to be antigenic and immunogenic both after invasive and oral vaccination (Marcondes and Hansen, 2008). Crude Quillaja saponin extracts stimulates measles' virus specific immune responses in mice, following oral immunization with plant based measles virus haemagglutinin protein (Pickering et al, 2006). Webster et al (2002) confirmed that the transgenic tobacco plants-derived MV-H protein vaccine, which when, modified to MV-H DNA vaccine, to prime-boost vaccination strategy demonstrated the MV hemagglutinin protein (MV-H) expression.…”

Section: Measlesmentioning

confidence: 99%

Transgenic plants as green factories for vaccine production

Kumar¹,

Raja²,

Wani³

et al. 2013

Afr. J. Biotechnol.

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Edible vaccine technology represents an alternative to fermentation based vaccine production system. Transgenic plants are used for the production of plant derived specific vaccines with native immunogenic properties stimulating both humoral and mucosal immune responses. Keeping in view the practical need of new technology for production and delivery of inexpensive vaccines, especially in developing world, plant derived edible vaccines is the best option in hand to combat infectious diseases. Plant derived vaccine is easy to administer, cost effective, readily acceptable, have increased safety, stability, versatility and efficacy. Several plant derived vaccines are under research, some are under clinical trials for commercial use. Like most biotechnology products, the IP situation for edible vaccines is complex as IP rights influence every stage of vaccine development.

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Crude saponins improve the immune response to an oral plant-made measles vaccine

Cited by 34 publications

References 37 publications

Soybean meal induces intestinal inflammation in common carp (Cyprinus carpio L.)

Soybean meal induces intestinal inflammation in common carp (Cyprinus carpio L.)

Transgenic Rice Expressing Amyloid β-peptide for Oral Immunization

Transgenic plants as green factories for vaccine production

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