Abstract. We report on the development of a hierarchy of models of cryogenic two-phase flow motivated by NASA plans to develop and maturate technology of cryogenic propellant loading on the ground and in space. The solution of this problem requires models that are fast and accurate enough to identify flow conditions, detect faults, and to propose optimal recovery strategy. The hierarchy of models described in this presentation is ranging from homogeneous movingfront approximation to separated non-equilibrium two-phase cryogenic flow. We compare model predictions with experimental data and discuss possible application of these models to on-line integrated health management and control of cryogenic loading operation.