Cryopeeling (Extensive Cryosurgery) for Treatment of Actinic Keratoses: An Update and Comparison

Abstract

Extensive cryosurgery (cryopeeling) is a highly effective method for removing actinic keratoses and preventing recurrences. The subsequent incidence of squamous cell carcinoma is also greatly reduced.

A Trial of Short Incubation, Broad-Area Photodynamic Therapy for Facial Actinic Keratoses and Diffuse Photodamage

“…The phototoxic reactions with erythema and edema seen in this study were considerable in intensity and associated with discomfort during the first 48 hours after treatment, but these reactions abated relatively rapidly in most patients, in sharp contrast to cryotherapy 41 or topical chemotherapy with fluorouracil 42 or imiquimod. [15][16][17] Despite the lack of uniformity in incubation times, light sources, drug vehicles, and exposure times and fluences, published studies on PDT demonstrate considerable efficacy for AKs.…”

Is cryosurgery less effective that conservative regimens in the treatment of actinic keratoses?

“…Taking these facts into account, it becomes obvious that cryotherapy/cryosurgery response rates may, indeed, widely vary by freeze time, extent of treated field and practitioner technique, as previously reported 11,30,34,35 . On the other hand, lege artis cryosurgery presents high cure rates in the hands of experienced cryosurgeons [26][27][28][29][30][31][32]36 and is widely available. Indeed, studies concentrated to cryosurgery with N 2 O or liquid nitrogen revealed high cure rates of 74-100% 1.5-12 months after treatment [26][27][28][29][30][31][32] .…”

“…On the other hand, lege artis cryosurgery presents high cure rates in the hands of experienced cryosurgeons [26][27][28][29][30][31][32]36 and is widely available. Indeed, studies concentrated to cryosurgery with N 2 O or liquid nitrogen revealed high cure rates of 74-100% 1.5-12 months after treatment [26][27][28][29][30][31][32] .…”

Estudo da pele humana fotoenvelhecida após tratamento com terapia fotodinâmica associada ao ácido 5-delta-aminolevulínico tópíco: avaliação imunoistoquímica, do colágeno e do tecido elástico

“…O fotoenvelhecimento pode ser tratado e/ou prevenido por meio de métodos clinicos ou cirúrgicos como: uso de substâncias químicas como as esfoliações, métodos mecânicos como a dermoabrasão, ou cirúrgicos como a eletrocoagulação, crioterapia ou laserterapia (Quadro 5) 25,[83][84][85][86][87][88] .…”