Cryosynthesis of nanosized drug substances

Morozov, Yu. N.; Utekhina, A. Yu.; Шабатин, В. П.; Чернышев, Владимир В.; Sergeev, G. B.

doi:10.1134/s1070363214050387

Cited by 10 publications

(11 citation statements)

References 5 publications

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“…8). 22,23 Two polymorphic forms of phenazepam have recently been reported with melting points of 207-212 C (b-form) and 226-227 C. 24 No evidence of either of these transitions was apparent in the DSC results presented (Fig. 21 HPLC indicated that these particular tablets contained the unlicensed phenazepam (results not shown) a potent benzodiazepine that has only recently been classied in the UK and is known to be around ve-times more potent than diazepam.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry

et al. 2015

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Increasing numbers of illicit and unlicensed medicines are in general circulation and regularly seized by the police and other regulatory authorities. Forensic identification of seized tablets tends to focus on visual appearance and chromatographic identification of the contained drug. This process is relatively time consuming and places a strain on forensic laboratories. It was therefore of interest to investigate the possible application of differential scanning calorimetry (DSC) as a fast and efficient tool to facilitate the identification of contained drug/s and associated tablet excipients. Sixteen different cases (Cases A to P) of diazepam tablets obtained from Police Scotland were characterised based on visual appearance (colour and manufacturers' logos), physical attributes (size, weight and hardness), drug type, drug quantity (HPLC) and thermal properties (DSC). Raw DSC data was further processed using principal component analysis (PCA) as an objective assessment of the thermograms obtained with a view to statistical grouping of different cases. Cases J/K, M/O and L/P could be paired on visual appearance and Cases B/C/E/G and J/K/L/P on tablet hardness (17-23 and 80-89 N respectively). HPLC indicated that 75% of the cases examined contained diazepam but less than half of these contained the recognised amount (10 mg);

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Section: Differential Scanning Calorimetrymentioning

confidence: 99%

A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry

et al. 2015

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“…5). Potexvirus movement proteins are known to belong to superfamily I helicases, which contain seven highly conservative NTPase/RNA helicase motifs constituting a NTPase/RNA helicase domain [14,15]. We have previously produced a set of PVX MP1 variants that carry deletions in different functional regions.…”

Section: Resultsmentioning

confidence: 99%

“…Alignment of the amino acid sequences of AltMV MP1, PVX MP1, PAMV MP1, and NMV MP1. The grey shading denote the MP1 conservative motifs (motifs I, IA, II, III, IV, V, VI)[15].…”

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confidence: 99%

Translational Cross-Activation of the Encapsidated RNA of Potexviruses

et al. 2017

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We had shown the genomic RNA of potexviruses potato virus X and the alternanthera mosaic virus to be inaccessible in vitro to ribosomes while in intact virion form, but the RNAs can be translationally activated following the binding of movement protein 1 (MP1) to virus particles. Here, we present the results of the follow-up study targeting two more potexvirus species -the Narcissus mosaic virus and the Potato aucuba mosaic virus. We found encapsidated potexviral RNA to share common translational features in vitro and the MP1 to be potent over homological virions of its "own" species and over heterological virions of other species, as well exhibiting selective specificity. Reciprocal cross-activation is observed among viral species phylogenetically either close or distant. There is direct evidence that MP1 binding to the end of the virion is necessary, but not sufficient, for translational activation of encapsidated RNA. KEYWORDS plant viruses, genomic RNA, cross-activation, potexviruses, translational activation, movement protein 1. ABBREVIATIONS CP -coat protein, PAMV -potato aucuba mosaic virus, AltMV -alternanthera mosaic virus, NMV -narcissus mosaic virus, MP1 -movement protein 1, PVX -potato virus X.

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“…In synthesizing and studying drug polymorphism, new possibilities have been opened up in light of an original strategy proposed in [41][42][43][44][45]. The developed technology is based on the conversion of the initial substance into a gaseous state in the course of its sublimation within the flow of an inert gas-carrier, followed by condensation on contact with a surface cooled by liquid nitrogen.…”

Section: Approaches For the Synthesis Of New Polymorphic Nanostructuresmentioning

confidence: 99%

“…The joint consideration of data obtained at cryotemperatures with those obtained at high temperatures showed that it is possible to carry out controlled syntheses in order to produce samples either with the same structure and different sizes or with the same size but different structures. When stored under standard conditions, the new nanoform of phenazepam was stable for more than two years [42]. By determining the solubility and dissolution rate, compared with the commercial form, the solubility of the new nanoform in water is higher by more than 30% and its dissolution rate increases by a factor of 4.9 [42].…”

Section: Effect Of Temperature On the Size Stability And Transformamentioning

confidence: 99%

The Polymorphism of Drugs: New Approaches to the Synthesis of Nanostructured Polymorphs

Chistyakov

Sergeev

2020

Pharmaceutics

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Among the significant problems of modern pharmacology are the low solubility and bioavailability of drugs. One way to resolve this problem is to obtain new polymorphic forms of drugs with improved physicochemical properties. Various approaches have been developed with this aim, including the preparation of co-crystals, the use of nanoparticles, or the use of compounds in the form of a salt. A promising direction in pharmacology concerns the production of new stable polymorphic structures. In this mini-review, we consider certain aspects of drug polymorphism, methods for the synthesis of polymorphs, and the stability, size, and transformation of crystalline polymorphs. Moreover, we summarize our results from several studies demonstrating the problems associated with the synthesis of new polymorphous modifications based on inert gases and cryotemperatures. The results indicate that the problems specific to drug polymorphisms have only been partly resolved, are of current interest, and require further development.

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Cryosynthesis of nanosized drug substances

Cited by 10 publications

References 5 publications

A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry

A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry

Translational Cross-Activation of the Encapsidated RNA of Potexviruses

The Polymorphism of Drugs: New Approaches to the Synthesis of Nanostructured Polymorphs

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