Cryptic and biochemical responses of young cuttlefish Sepia officinalis exposed to environmentally relevant concentrations of fluoxetine

Adverse effects of the SSRI antidepressant sertraline on early life stages of marine invertebrates

“…This percentage was not significant and less than 10% at all the concentrations tested. The results are comparable with those obtained in the C. gigas 36 h embryotoxicity assay (Di Poi et al, 2014). The developmental arrest to the trochophora stage induced by SRT in both mussels and oysters is in line with observed early development (from 24 h pf) of serotonergic components in bivalve embryos (Kreiling et al, 2001;Voronezhskaya et al, 2008).…”

“…The molecular machinery that governs serotonin signaling across neurons is well conserved among vertebrates and invertebrates (Curran and Chalasani, 2012;Fent et al, 2006;Fong, 1998). In marine invertebrates, serotonin regulates important physiological and behavioral processes like survival, development, larval settlement or locomotion (Di Poi et al, 2014;Pires and Woollacott, 1997;Stricker and Smythe, 2000;Yaguchi and Katow, 2003;Yamamoto et al, 1996Yamamoto et al, , 1999. However, it remains unknown whether non-target marine organisms may show similar changes to the intended pharmacological responses of SSRIs in humans, such as alteration in behaviors ( Van der Ven et al, 2005).…”

Practical approaches to adverse outcome pathway development and weight‐of‐evidence evaluation as illustrated by ecotoxicological case studies

“…Focusing on records of whole‐organism responses, which typically would be more directly related to AOs, 4 studies reported effects of fluoxetine or sertraline at concentrations ≤0.001 μg/L. These records identified effects on swimming behavior in the crustacean Echinogammarus marinus and changes in feeding strikes, pigmentation, courtship, and burrowing in 2 species of mollusks . The ECOTOX output suggested that, among aquatic species, mollusks and crustaceans may be uniquely sensitive to fluoxetine and related chemicals, a conclusion consistent with that of others .…”

Behavioral development in embryonic and early juvenile cuttlefish (Sepia officinalis)

“…Ultimately, these environmental conditions can influence survival, growth rate, hatching time, and post natal behavior. For example, extreme salinities or contamination by pollutants (e.g., heavy metals or pharmaceutical residues), which can slow or interfere with development, may result from being located close to shore (Bidel et al, ; Bloor et al, ; Di Poi, Bidel, Dickel, & Bellanger, ; Paulij, Bogaards, & Denucé, ; Paulij, Zurburg, Denuce, & Van Hannen, ). As a mostly semelparous species with only a single spawning period at the end of life (Boletzky, ), there is presumably strong selective pressure on females to lay eggs in locations, times and in densities that maximize offspring survival (Bloor et al, ).…”