Cryptic Nocardia nova brain abscess postradiation treatment and neurosurgery in a patient with small cell lung cancer: A case report and review of the literature

Abel, Stephen; Hasan, Shaakir; Kujawski, Brandon; Talwar, Anjana; Betler, James; Wegner, Rodney E.; Colonias, Athanasios; Aziz, Khaled

doi:10.1016/j.adro.2016.08.004

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…N. nova is more commonly identified in patients with bone marrow and solid organ transplants [ 27 , 28 ] who develop disseminated disease (with secondary cutaneous involvement) [ 29 ]. Most reported cases of N. nova infection show severe pulmonary disease and/or brain abscesses in immunocompromised patients [ 30 , 31 ], where a lesser number of pulmonary and central nervous system complications are reported in immunocompetent hosts [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous nocardiosis caused by Nocardia nova with possible Apremilast contribution

Lenskaya

DeChavez

Kaufman

et al. 2021

IDCases

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Primary cutaneous nocardiosis accounts for 5–8 % of all nocardiosis cases and represents a diagnostic dilemma among immunocompetent and immunocompromised hosts. Herein, we present a case of a 30-year-old male with history of psoriasis with recent addition of Apremilast. Patient received intralesional triamcinolone injections for psoriatic plaques on the hands and abdomen prior to traveling to warm climate vacation. While on vacation, patient developed hand swelling and painful, red nodules on the dorsal hands and abdomen, sites where he received intralesional injections. Patient was empirically given doxycycline, but continued to develop new nodules. An abdominal lesion was biopsied for H&E and tissue culture. Tissue culture revealed beaded gram-positive rods identified as Nocardia nova by MALDI-TOF. Patient was switched to trimethoprim-sulfamethoxazole with significant improvement. This case represents an atypical primary cutaneous nocardiosis with Nocardia nova most likely in the setting of intralesional steroid injections and possible contribution of Apremilast.

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Section: Discussionmentioning

confidence: 99%

Primary cutaneous nocardiosis caused by Nocardia nova with possible Apremilast contribution

Lenskaya

DeChavez

Kaufman

et al. 2021

IDCases

View full text Add to dashboard Cite

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Updated Review onNocardiaSpecies: 2006–2021

et al. 2022

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Nocardia paucivorans cerebellar abscess: Surgical and pharmacotherapy

Shimizu¹,

Tsuchiya²,

Fujisawa³

2019

Surg Neurol Int

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Background:Nocardia species are ubiquitous in nature and mainly cause pulmonary disease in humans; however, they can also infect the central nervous system and skin. The management of cerebellar nocardiosis is troublesome and requires multiple considerations of the severity of the underlying systemic disease, difficulties in identifying the bacterium, and frequent delay in initiating adequate therapy.Case Description:We report a 52-year-old diabetic female patient with Nocardia paucivorans cerebellar abscesses. Brain magnetic resonance imaging (MRI) revealed innumerable small ring-enhancing lesions of posterior fossa. In this report, we present a case of primary single cerebellar abscesses due to N. paucivorans. Early diagnosis and surgical interventions were significant for the patient. The diagnosis was confirmed by DNA sequencing and the organism was susceptible to trimethoprim–sulfamethoxazole (TMP/SMX). The patient was successfully treated with drugs and surgical excision.Conclusion:According to the literature, surgical excision or aspiration of cerebellar abscess seems to provide favorable outcomes. In our experience, a successful outcome was achieved with subtotal resection and prolonged adequate antibiotic therapy.

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Cryptic Nocardia nova brain abscess postradiation treatment and neurosurgery in a patient with small cell lung cancer: A case report and review of the literature

Cited by 3 publications

References 9 publications

Primary cutaneous nocardiosis caused by Nocardia nova with possible Apremilast contribution

Primary cutaneous nocardiosis caused by Nocardia nova with possible Apremilast contribution

Updated Review onNocardiaSpecies: 2006–2021

Nocardia paucivorans cerebellar abscess: Surgical and pharmacotherapy

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