Cryptocaryone, a Natural Dihydrochalcone, Induces Apoptosis in Human Androgen Independent Prostate Cancer Cells by Death Receptor Clustering in Lipid Raft and Nonraft Compartments

Chen, Yi-Cheng; Kung, Fan-Lu; Tsai, Ian‐Lih; Chou, Tsung-Hsien; Chen, Ih-Sheng; Guh, Jih‐Hwa

doi:10.1016/j.juro.2010.01.065

Cited by 31 publications

(28 citation statements)

References 27 publications

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“…31,37 Lipid rafts are regions of pla sma membranes with a distinct, characteristic structural composition, that participate in various cellular functions, including protein trafficking, transcytosis, endocytosis, cell survival, and cell death. 37,38 CBD induces lipid raft coalescence, which has been linked to critical signaling pathways, such as apoptosis. [37][38][39]…”

Section: Discussionmentioning

confidence: 99%

Protective effects of cannabidiol on cuprizone-induced demyelination in C57BL/6 mice

Sajjadian

Kashani

Pasbakhsh

et al. 2017

J. contemp. med. sci.

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Objective Experimental and clinical studies suggest that oxidative stress plays an important role in the pathogenesis of multiple sclerosis. Multiple studies have shown that non-psychoactive cannabinoid, cannabidiol (CBD) exerts antioxidant effects, and has recently been approved for treatment of inflammation, pain, and spasticity associated with MS patients. The aim of this study is to determine the effectiveness of CBD in a multiple sclerosis mouse model, i.e. cuprizone-induced demyelination. Methods Adult male BL/6 mice were fed with 0.2% cuprizone for 5 weeks which caused severe demyelination of the corpus callosum (CC). Animals were simultaneously treated with 5 mg•kg −1 CBD by daily intra-peritoneal injections. Using immunohistochemistry and transmission electron microscope, we evaluated the effects of CBD on demyelination, malondialdehyde levels and the activity of reduced glutathione, catalase and superoxide dismutase was evaluated by Biochemical analysis. Results CBD ameliorate the cuprizone-induced demyelination and microglia accumulation. Biochemical analysis showed that oxidative stress induced by cuprizone was reduced by CBD. Conclusion Our data implicate that CBD attenuates destructive effects of cuprizone in the CC by decreasing oxidative stress and microglia repletion.

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Section: Discussionmentioning

confidence: 99%

Protective effects of cannabidiol on cuprizone-induced demyelination in C57BL/6 mice

Sajjadian

Kashani

Pasbakhsh

et al. 2017

J. contemp. med. sci.

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“…Nystatin partially reversed the increased apoptosis seen with the combination therapy. It is now known that several drugs that influence DR4/5 receptor clustering in lipid rafts including cryptocaryone (Chen et al, ), cisplatin (Xu et al, ), and oxaliplatin (Xu et al, ) have similar positive outcomes in combination with TRAIL.…”

Section: Membrane Proteins: the Effect Of Receptor Mobility And Clustmentioning

confidence: 99%

Precision engineering of targeted nanocarriers

Deci

Liu

Dinh³

et al. 2018

WIREs Nanomed Nanobiotechnol

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Since their introduction in 1980, the number of advanced targeted nanocarrier systems has grown considerably. Nanocarriers capable of targeting single receptors, multiple receptors, or multiple epitopes have all been used to enhance delivery efficiency and selectivity. Despite tremendous progress, preclinical studies and clinically translatable nanotechnology remain disconnected. The disconnect in targeting efficacy may stem from poorly-understood factors such as receptor clustering, spatial control of targeting ligands, ligand mobility, and ligand architecture. Further, the relationship between receptor distribution and ligand architecture remains elusive. Traditionally, targeted nanocarriers were engineered assuming a "static" target. However, it is becoming increasingly clear that receptor expression patterns change in response to external stimuli and disease progression. Here, we discuss how cutting-edge technologies will enable a better characterization of the spatiotemporal distribution of membrane receptors and their clustering. We further describe how this will enable the design of new nanocarriers that selectively target the site of disease. Ultimately, we explore how the precision engineering of targeted nanocarriers that adapt to receptor dynamics will have the potential to drive nanotechnology to the forefront of therapy and make targeted nanomedicine a clinical reality. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Lipid-Based Structures Biology-Inspired Nanomaterials > Protein and Virus-Based Structures.

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“…56 In a separate study it was further investigated the mechanism of the antiproliferative activity in human prostate cancer PC-3 cells (IC 50 = 1.6 µM) and it seemed induced by apoptosis through the activation of caspase-8 and 3. 57 …”

Section: Natural Glut Inhibitorsmentioning

confidence: 99%

Anticancer agents interacting with membrane glucose transporters

2016

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The altered metabolism observed in cancer cells generally consists in increased glucose uptake and glycolytic activity. This is associated with an overexpression of glucose transporter proteins (GLUTs), which facilitate glucose uptake across the plasma membrane and play a crucial role in the survival of cancer cells. Therefore GLUTs are considered as suitable targets for the treatment of cancer. Herein we review some of the most relevant GLUT inhibitors that have been recently developed as prospective anticancer agents.

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Cryptocaryone, a Natural Dihydrochalcone, Induces Apoptosis in Human Androgen Independent Prostate Cancer Cells by Death Receptor Clustering in Lipid Raft and Nonraft Compartments

Abstract: We suggest that cryptocaryone has anticancer activity via the stimulation of death receptor and associated molecule clustering, leading to caspase-8 and 3 activation, and apoptosis in prostate cancer cells.

Cited by 31 publications

References 27 publications

Protective effects of cannabidiol on cuprizone-induced demyelination in C57BL/6 mice

Protective effects of cannabidiol on cuprizone-induced demyelination in C57BL/6 mice

Precision engineering of targeted nanocarriers

Anticancer agents interacting with membrane glucose transporters

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