Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review

Choe, Young June; Blatt, Daniel B.; Yalçındağ, Ali; Geffert, Sara F; Bobenchik, April M.; Michelow, Ian C.

doi:10.1093/jpids/piz039

Cited by 20 publications

(25 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous culture-based studies showed a higher prevalence of Aspergillus and Penicillium [20][21][22]42], which are traditionally the most expected genus in indoors environments. It seems that this is a bias of culture-based procedures as our results are coincident with other molecular approaches [24,43,56]. Nevertheless, Penicillium polonicum and two species of Aspergillus (A. subversicolor and A. flavus) were detected in 50% (6/12) and 33.3% (4/12) of the samples from houses and the genera were also cultured.…”

Section: The Culturable Mycobiomesupporting

confidence: 82%

The Domestic Environment and the Lung Mycobiome

et al. 2020

View full text Add to dashboard Cite

This study analyzes the relationship between the mycobiome of the Lower Respiratory Tract (LRT) and the fungi in the domestic environment. Samples studied consisted of Broncho-Alveolar Lavage (BAL) from 45 patients who underwent bronchoscopy for different diagnostic purposes, and dust and air from the houses (ENV) of 20 of them (44.4%). Additionally, five bronchoscopes (BS) were also analyzed and negative controls were included for every procedure. All samples were processed for DNA extraction and cultures, which were performed in Sabouraud Dextrose and Potato Dextrose Agar. The fungal Internal Transcribed Spacer (ITS2) was sequenced by the Solexa/Illumina system and sequences were analyzed by QIIME 1.8.0 and compared with the UNITE Database for identification. The similarity between the two fungal communities (BAL and ENV) for a specific patient was assessed via the percentage of coincidence in the detection of specific operational taxonomic units (OTUs), and about 75% of co-occurrence was detected between the mycobiome of the LRT and the houses. Cultures confirmed the presence of the core mycobiome species. However, the low rate of isolation from BAL suggests that most of its mycobiome corresponds to non-culturable cells. This likely depends on the patient’s immune system activity and inflammatory status.

show abstract

Section: The Culturable Mycobiomesupporting

confidence: 82%

The Domestic Environment and the Lung Mycobiome

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Interestingly, the isolate of C. orthopsilosis from the hands of a HCW may reinforce the hypothesis that, similar to C. parapsilosis, it may have been transferred from the hands of HCWs [40]. Moreover, isolation of A. melanogenum, N. albida, and N. liquefaciens from high touch areas, which are reported to have elevated MIC values to various antifungals [41][42][43] and finding Aureobasidium melanogenum in both blood and the environment are worrisome. Findings obtained from environmental screening and microsatellite typing may collectively imply the lack of proper hygiene (both hands and hospital environments) and necessitate the application of effective infection control strategies to eradicate/control fungemia caused by various yeast species.…”

Section: Discussionmentioning

confidence: 61%

Candida tropicalis is the most prevalent yeast species causing candidemia in Algeria: the urgent need for antifungal stewardship and infection control measures

Megri

Arastehfar

Boekhout

et al. 2020

Antimicrob Resist Infect Control

View full text Add to dashboard Cite

Background: Despite being associated with a high mortality and economic burden, data regarding candidemia are scant in Algeria. The aim of this study was to unveil the epidemiology of candidemia in Algeria, evaluate the antifungal susceptibility pattern of causative agents and understand the molecular mechanisms of antifungal resistance where applicable. Furthermore, by performing environmental screening and microsatellite typing we sought to identify the source of infection. Methods: We performed a retrospective epidemiological-based surveillance study and collected available blood yeast isolates recovered from the seven hospitals in Algiers. To identify the source of infection, we performed environmental screening from the hands of healthcare workers (HCWs) and high touch areas. Species identification was performed by API Auxa-Color and MALDI-TOF MS and ITS sequencing was performed for species not reliably identified by MALDI-TOF MS. Antifungal susceptibility testing followed CLSI M27-A3/S4 and included all blood and environmental yeast isolates. ERG11 sequencing was performed for azole-resistant Candida isolates. Microsatellite typing was performed for blood and environmental Candida species, where applicable.

show abstract

“…In this context, it should also be added that Cr albidus, which is a known environmental fungus, was also reported to be involved in rare human systemic infections in immunocompromised individuals. 30,31 We could not detect the presence of dermatophytes in the Israeli beach sands, which possibly might be due to the high temperature of the sands. The presence of dermatophytes was reported rather scarcely in the literature, 32,33 and might be associated with specific ecological conditions, such as those found on the Madeira archipelago.…”

Section: F I G U R Ementioning

confidence: 66%

Fungi in sands of Mediterranean Sea beaches of Israel—Potential relevance to human health and well‐being

Frenkel

Yunik

Fleker³

et al. 2020

Mycoses

View full text Add to dashboard Cite

Sand and water of recreational waterbodies, such as sea, river or lake beach sites, have been shown to harbour microorganisms. 1,2 Moreover, the latter have also been shown to possibly affect human health, acting as source for enteric infections caused by faecal contamination of sand from human or animal origin. 1,3 It should be added that accumulation of data on possible faecal contamination of beaches led to the initiation of regulatory measures to monitor sand/water contamination by checking for the

show abstract

Cryptococcus albidus Fungemia in an Immunosuppressed Child: Case Report and Systematic Literature Review

Cited by 20 publications

References 36 publications

The Domestic Environment and the Lung Mycobiome

The Domestic Environment and the Lung Mycobiome

Candida tropicalis is the most prevalent yeast species causing candidemia in Algeria: the urgent need for antifungal stewardship and infection control measures

Fungi in sands of Mediterranean Sea beaches of Israel—Potential relevance to human health and well‐being

Contact Info

Product

Resources

About