Cryptococcus neoformans Abscess and Osteomyelitis in an Immunocompetent Patient with Tuberculous Lymphadenitis

Abstract

Infection with Cryptococcus neoformans usually occurs in immunocompromised hosts and may occur in immunocompetent patients. Of all cryptococcal infections, 10-40% of patients have no apparent immune deficiency. Disseminated disease may occur in up to 62% of HIV-seronegative patients with cryptococcosis; however, cryptococcal osteomyelitis is rare. Here, we report an immunocompetent patient with cryptococcal vertebral osteomyelitis and concomitant tuberculous lymphadenitis. The patient received 12 weeks of fluconazole and a 1-year course of anti-tuberculous agents, with complete recovery.

Cryptococcosis and tuberculosis co-infection at a university hospital in Taiwan, 1993–2006

“…Over the previous 20 years, only nine cases of co-infection have been reported in the English literature [6][7][8][9][10][11][12]. Our results show that cryptococcosis and TB co-infection, although rare in the general population, is not uncommon in patients with either cryptococcosis or TB and that it can develop in patients without an evident immunocompromised state.…”

Three Cases of Concurrent Infection with <i>Mycobacterium tuberculosis</i> and <i>Cryptococcus neoformans</i>

“…Over the previous two decades, only a few cases of co-infection have been reported in the English literature (6)(7)(8)(9)(10)(11)(12). Between 1993 and 2006, cryptococcosis and tuberculosis co-infection was reported at one university hospital in Taiwan.…”

Disseminated cryptococcosis with recurrent multiple abscesses in an immunocompetent patient: a case report and literature review

“…To our knowledge, only five cases with extra-pulmonary and extra-cranial cryptococcal abscess has been reported in immunocompetent patients up to now (Table 1), but none of them was presented with such recurrent multiple soft-tissue abscesses for more than half a year like this case [3–7]. …”