Cryptosporidium parvum ile Enfekte Buzağılarda Akut Faz Reaktanları ve Antioksidant Kapasitenin Araştırılması

Çenesiz, Metin; Öztürk, Atakan; DALĞIN, Duygu; Yarım, Gül Fatma; Çiftçi, Gülay; Оздемир, Рамазан; Güzel, Murat; Kazak, Filiz; Çenesiz, Sena

doi:10.9775/kvfd.2016.17183

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Haptoglobin has been reported to be present in very low concentrations (<0.1 mg/mL) in healthy animals. But its concentrations increase and remain high in many bacterial, viral, parasitic and inflammatory diseases as long as the stimulus persists [7,[25][26][27][28] . It is a nonspecific marker of tissue damage, and suggested to be used to determine prognosis and severity of the diseases.…”

Section: Discussionmentioning

confidence: 99%

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Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi

Bozukluhan¹,

Merhan²,

Gokce³

et al. 2018

Kafkas Univ Vet Fak Derg

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The aim of the present study was to determine oxidative stress and acute phase response in naturally infected sheep with poxvirus. For this purpose, 20 poxvirus infected and 10 clinically healthy sheep were used in the study. In these animals, alkaline phosphatase (ALP), aspartate aminotransferase (AST) activity, haptoglobin, ceruloplasmin, urea, creatinine, albumin, iron (Fe), malondialdehyde (MDA) and reduced glutathione (GSH) concentrations were determined. The present study determined that the concentrations of haptoglobin, ceruloplasmin, urea, creatinine, MDA and ALP, AST activity were significantly increased, and albumin, Fe and GSH concentrations were significantly decreased in the sheeppox virus infected group compared to the control group. Results of this study indicated that oxidative stress and acute phase response develop in sheep infected with poxvirus. Keywords: Acute phase proteins, Biochemical parameters, Sheeppox Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi ÖzÇalışma poksvirüs ile doğal enfekte koyunlarda, oksidatif stres ve akut faz cevabı belirlemek amacıyla yapıldı. Çalışmada 20 adet çiçek hastalığı ile enfekte ve 10 adet klinik olarak sağlıklı koyun kullanıldı. Hayvanlarda alkalen fosfataz (ALP), aspartat aminotransferaz (AST) aktivitesi, haptoglobin, seruloplazmin, üre, kreatinin, albümin, demir (Fe), malondialdehit (MDA) ve redükte glutatyon (GSH) konsantrasyonları belirlendi. Çalışmada, poksvirus ile enfekte koyunlar ile kontrol grubundaki hayvanlar karşılaştırıldığında haptoglobin, seruloplazmin, üre, kreatinin, MDA değerleri ile ALP ve AST aktivitelerinin yükseldiği, albümin, Fe ve GSH konsantrasyonunun ise kontrol grubuna göre düştüğü belirlendi. Bu çalışmada poksvirus ile enfekte koyunlarda akut faz yanıtın oluştuğu ve oksidatif stresin geliştiği kanısına varıldı.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Acute phase proteins (APP) are circulating blood proteins primarily synthesized by the liver in a few hours in response to inflammatory stimulus [7][8][9][10] . Acut phase proteins are defined as positive APP, which serum concentrations increase and negative APP, which serum concentrations decrease in response to APR [11,12] .…”

Section: Introductionmentioning

confidence: 99%

Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi

Bozukluhan¹,

Merhan²,

Gokce³

et al. 2018

Kafkas Univ Vet Fak Derg

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Investigation of some acute phase proteins and antioxidant/oxidant system in infected sheep with bluetongue virus disease

Merhan

Yılmaz

Bozukluhan

et al. 2022

Journal of Advances in VetBio Science and Techniques

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In this study, it was aimed to determine the level of some acute phase proteins and oxidative stress in sheep infected with bluetongue virus disease. Twenty five bluetongue virus-infected and 10 healthy sheep were used. Blood samples from V. jugularis of animals were taken into tubes without anticoagulant. Total antioxidant (TAC)/oxidant capacity (TOC), haptoglobin, serum amyloid A (SAA), ceruloplasmin and albumin levels were determined colorimetrically. Oxidative stress index (OSI) was calculated using the formula. As a result of the analysis, when sheep infected with bluetongue virus disease and healthy sheep were compared, it was determined that SAA, TOC and OSI concentrations increased, albumin and TAC values decreased. However haptoglobin and ceruloplasmin levels increased but were statistically insignificant. In conclusion, it was concluded that oxidative stress occurs in sheep infected with bluetongue virus disease and that acute phase proteins haptoglobin, SAA and ceruloplasmin can be used as inflammation markers.

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Cryptosporidium parvum ile Enfekte Buzağılarda Akut Faz Reaktanları ve Antioksidant Kapasitenin Araştırılması

Cited by 2 publications

References 20 publications

Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi

Poksvirüs İle Doğal Enfekte Koyunlarda, Bazı Akut Faz Proteinler, Biyokimyasal Parametreler ve Oksidatif Stresin Belirlenmesi

Investigation of some acute phase proteins and antioxidant/oxidant system in infected sheep with bluetongue virus disease

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