Investigation of some acute phase proteins and antioxidant/oxidant system in infected sheep with bluetongue virus disease

Abstract

In this study, it was aimed to determine the level of some acute phase proteins and oxidative stress in sheep infected with bluetongue virus disease. Twenty five bluetongue virus-infected and 10 healthy sheep were used. Blood samples from V. jugularis of animals were taken into tubes without anticoagulant. Total antioxidant (TAC)/oxidant capacity (TOC), haptoglobin, serum amyloid A (SAA), ceruloplasmin and albumin levels were determined colorimetrically. Oxidative stress index (OSI) was calculated using the formula. As a result of the analysis, when sheep infected with bluetongue virus disease and healthy sheep were compared, it was determined that SAA, TOC and OSI concentrations increased, albumin and TAC values decreased. However haptoglobin and ceruloplasmin levels increased but were statistically insignificant. In conclusion, it was concluded that oxidative stress occurs in sheep infected with bluetongue virus disease and that acute phase proteins haptoglobin, SAA and ceruloplasmin can be used as inflammation markers.

Determination of Levels of Some Acute Phase Proteins, Tumor Necrosis Factor-α, Interleukin-1 and Interleukin-6 in Cattle with Trichophythosis

“…SAA, which can increase over 1000 times in the circulation in inflammatory conditions, has functions such as preventing antibody formation by lymphocytes, inducing collagenase, and increasing leukocyte adhesion to endothelial cells (Petersen et al, 2004;Murata et al, 2004). The levels of SAA increases in bacterial (Merhan et al, 2017b), viral (Merhan et al, 2017c), and parasitic infections (Bozukluhan et al, 2017). In addition, serum levels increase in ketosis (Brodzki et al, 2021), after operations (Bozukluhan and Gökçe, 2007), and in fasting for more than 3 days (Katoh et al, 2002).…”