Crystal data of acetylcholine chloride

Allen, Kristi

doi:10.1107/s0365110x62002741

Cited by 17 publications

(3 citation statements)

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“…Liley (1956) (Krnjevi6' & Mitchell, 1961). An estimate of 4000 molecules per vesicle has been made (Hubbard, 1973 (Allen, 1962;Canepa, 1964). If the figure of 4000 molecules/vesicle is accepted, then it would appear that of the 0-45 p-mole/mmn.…”

Section: Discussionmentioning

confidence: 99%

The effect of curare on the release of acetylcholine from mammalian motor nerve terminals and an estimate of quantum content.

Fletcher¹,

Forrester²

1975

The Journal of Physiology

113

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SUMMARY1. Curarized and non-curarized rat hemidiaphragm muscles were indirectly stimulated in vitro.2. The fluid bathing the active curarized muscles was eluted through a dextran gel (Sephadex G-10), effecting a complete separation of ACh from curare. The acetylcholine fraction was then assayed on an isometric leech muscle preparation.3. Prostaglandin (PGE1) in a concentration fifteen times that estimated to be released from the skeletal muscle preparation did not affect the response of leech muscle to ACh.4. The amount of ACh released by curarized muscles (4.9 x 10-18 mole/ impulse. junction) was not significantly different from that released by non-curarized muscles (46 x 10-18 mole/impulse. junction). These quantities are similar to those obtained by previous workers. It is concluded that curare in a paralytic dose does not affect the output of ACh from motor nerve terminals stimulated at low frequencies.5. Spontaneous release of ACh from non-curarized muscles was estimated at 0-45-0'65 p-mole/min. hemidiaphragm. It is calculated that only 2 % of this amount could give rise to post-synaptic electrical events, the remainder having a non-synaptic source. 6. The number of molecules of 'quantal' ACh released by stimulated muscle is calculated as 2-5 x 106/impulse . junction, taking account of the non-synaptic release. The number of ACh molecules in one quantum was estimated to be 6250, an amount that could be easily accommodated in one synaptic vesicle.

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Section: Discussionmentioning

confidence: 99%

The effect of curare on the release of acetylcholine from mammalian motor nerve terminals and an estimate of quantum content.

Fletcher¹,

Forrester²

1975

The Journal of Physiology

113

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“…When ACh is adsorbed and clamped by the membrane receptors, the interreceptor distances increase from 10 A to a maximum of 12. 6 A. This increase would be sufficient to increase the membrane permeability to N a + and K+.…”

Section: A Mechanism For the Release Of Adsorbed Achmentioning

confidence: 97%

The Role of Ionic Environment Forces in the Chemical Transmission of Nerve Impulses by Acetylcholine

Canepa¹

1967

Annals of the New York Academy of Sciences

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“…Acetylcholine chloride crystallizes in the orthorhombic unit cell, space group P212~2 ~ with Z = 4. The parameters of the elementary cell are (in nm): a = 0.628, b = 0.993, c = 1.526 at T--298 K [8], a = 0.9890, b = 1.5324, c = 0.6302 at T= 105 K [9], and a = 1.0071, b = 1.5511, c = 0.6380 at 293 K [t0]. The structure of the acetylcholine cation is shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

1H NMR study of molecular dynamics of acetylcholine chloride

et al. 2004

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The longitudinal relaxation time T~ and the second momem M 2 of tH nuclear magnetic resonance line in a wide temperature range have been measured for acetylcholine chloride. Two different types of the methyl groups reorientation occurred. The first type was the hindered rotation of the methyl group denoted as C(I)H~ about the threefold symmetry axis. The second type was the reorientation of the trimethyl group -N(CH3) 3 around the pseudo C; axis of C(6)-N(7) bond, which accompanied the standard C 3 motion of the methyl group. The Dunn-McDowell model was applied to analyze the dynamics observed.

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Crystal data of acetylcholine chloride

Cited by 17 publications

References 1 publication

The effect of curare on the release of acetylcholine from mammalian motor nerve terminals and an estimate of quantum content.

The effect of curare on the release of acetylcholine from mammalian motor nerve terminals and an estimate of quantum content.

The Role of Ionic Environment Forces in the Chemical Transmission of Nerve Impulses by Acetylcholine

1H NMR study of molecular dynamics of acetylcholine chloride

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