Crystal structure, DNA interaction, and antiproliferative activity of the cobalt(II) complex of demethylcantharate and imidazole

Lin, Qiang; Wang, Yunyun; Ye, Feng; Yan, Dongmei; Wang, Yanjun; Zhang, Fan

doi:10.1080/00958972.2011.557150

Cited by 9 publications

(2 citation statements)

References 14 publications

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“…They have potential application because of their excellent optical, electrical, magnetic, catalytic and biological activity features. Some Cobalt phenanthroline complexes have been synthesized and reported [1][2][3][4][5][6][7][8]. In this paper, the new Co complex is reported.…”

Section: Introductionmentioning

confidence: 99%

Di(1,10-phenanthroline)-Cobalt(II) Nitrate Iodate Dihydrate, Co(C12H8N2)2NO3I(H2O)2

Liu

Guo

Xiao

et al. 2013

AMR

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A novel Co complex Co (C12H8N2)2NO3I(H2O)2has been synthesized from hydrothermal reaction and the crystal structure has been determined by means of single-crystal X-ray diffraction. The Co atom is coordinated with four N atoms from two 1,10-phenanthroline and two O atoms from NO3-, presenting a distorted octahedron geometry. The crystal structure is stabilized by intermolecular O-H...O and O-H...I hydrogen bonds interaction.

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Section: Introductionmentioning

confidence: 99%

Di(1,10-phenanthroline)-Cobalt(II) Nitrate Iodate Dihydrate, Co(C12H8N2)2NO3I(H2O)2

Liu

Guo

Xiao

et al. 2013

AMR

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“…Transition metal complexes have potential as structure-selective binding agents for nucleic acids [10][11][12][13][14]. Some Cobalt complexes have been synthesized and reported [15][16][17][18]. In this paper, the new complex is reported.…”

Section: Introductionmentioning

confidence: 99%

Study on a Structure of 2,6-pyridine-dicarboxylic Acid Cobalt Calcium Hexahydrate

Liu

Xiao

Guo

et al. 2013

AMR

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The complex C28H32CaCoN4O24has been synthesized from hydrothermal reaction and the crystal structure has been determined by means of single-crystal X-ray diffraction. The Co atom is six-coordinated by two N atoms, four O atoms from two 2,6-pyridinedicarboxylic acid. The Ca atom is eight-coordinated by two N atoms, six O atoms from two 2,6-pyridinedicarboxylic acid and two water molecular. The crystal packing is stabilized by O-H...O hydrogen bonding interactions.

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Crystal Structures, Interactions with Biomacromolecules and Anticancer Activities of Mn(II), Ni(II), Cu(II) Complexes of Demethylcantharate and 2-Aminopyridine

et al. 2012

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Three novel transition metal complexes (Hapy)(2)[M(DCA)(2)]·6H(2)O (M = Mn(II) (1), Ni(II) (2), Cu(II) (3); DCA = demethylcantharate, 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate, C(8)H(8)O(5); Hapy = 2-aminopyridine acid, C(5)H(7)N(2)) were synthesized and characterized by elemental analysis, infrared spectra, thermogravimetric analysis and X-ray diffraction. DNA binding properties of the complexes were investigated by electronic absorption spectra, fluorescence spectra and viscosity measurements. Results indicated the complexes could bind to DNA through partial intercalation mode with binding constants K ( b )/(L·mol(-1)) of 1.91 × 10(4) (1), 5.13 × 10(4) (2) and 1.12 × 10(5) (3) at 298 K. Meanwhile, the interactions of the complexes with BSA were also studied by fluorescence spectra. The results suggested that the complexes could quench the fluorescence of BSA through static quenching with the binding constants K ( A )/(L·mol(-1)) of 1.44 × 10(6) (1), 1.14 × 10(7) (2) and 2.98 × 10(4) (3). And the main contribution was tryptophan residues of BSA. The antiproliferative activity test revealed that complexes showed more intense inhibition ratios against human hepatoma cells lines and human gastric cancer cells lines in vitro. Copper(II) complex (3) possesses the strongest inhibition ratio against human hepatoma cells.

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Crystal structure, DNA interaction, and antiproliferative activity of the cobalt(II) complex of demethylcantharate and imidazole

Cited by 9 publications

References 14 publications

Di(1,10-phenanthroline)-Cobalt(II) Nitrate Iodate Dihydrate, Co(C<sub>12</sub>H<sub>8</sub>N<sub>2</sub>)<sub>2</sub>NO<sub>3</sub>I(H<sub>2</sub>O)<sub>2</sub>

Di(1,10-phenanthroline)-Cobalt(II) Nitrate Iodate Dihydrate, Co(C<sub>12</sub>H<sub>8</sub>N<sub>2</sub>)<sub>2</sub>NO<sub>3</sub>I(H<sub>2</sub>O)<sub>2</sub>

Study on a Structure of 2,6-pyridine-dicarboxylic Acid Cobalt Calcium Hexahydrate

Crystal Structures, Interactions with Biomacromolecules and Anticancer Activities of Mn(II), Ni(II), Cu(II) Complexes of Demethylcantharate and 2-Aminopyridine

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