Crystal structure of 1,5-diethyl-3′,5′-diphenyl-1,5-dihydro-3′H-spiro[pyrazolo[3,4-d]pyrimidine-4,2′-[1,3,4]thiadiazole]

Abstract

In the title compound, C22H22N6S, the pyrazolo­[3,4-d]pyrimidine rings system is almost planar, with the r.m.s. deviation for the fitted atoms being 0.011 Å. The two phenyl groups linked to the thia­diazole ring are nearly perpendicular to the fused-ring system as indicated by the dihedral angles of 86.93 (10) and 83.35 (11)°. However, the phenyl rings are almost coplanar with the thia­diazole ring (r.m.s. deviation = 0.015 Å), forming dihedral angles of 10.44 (11) and 10.06 (12)°. In the crystal, mol­ecules are connected into a supra­molecular layer in the ac plane via C—H⋯π inter­actions.

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

“…In continuation of our work on the synthesis of the excess of allopurinol [16][17][18][19][20][21][22][23], we have envisioned the synthesis new pyrazolo [3,4-b]pyridine derivatives by thionation, alkylation and 1,3-dipolar cycloaddition reactions in order to evaluate their inhibitory effect of α-amylase and α-glucosidase. The melting points were taken on an electrothermal capillary melting point apparatus.…”