Crystal structure of 1-methyl-4-methylsulfanyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidine

Fal, M. El; Ramli, Youssef; Essassi, El Mokhtar; Saadi, Mohamed; Ammari, Lahcen El

doi:10.1107/s1600536814025239

Cited by 2 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In continuation of our work on the synthesis of the excess of allopurinol [16][17][18][19][20][21][22][23], we have envisioned the synthesis new pyrazolo [3,4-b]pyridine derivatives by thionation, alkylation and 1,3-dipolar cycloaddition reactions in order to evaluate their inhibitory effect of α-amylase and α-glucosidase. The melting points were taken on an electrothermal capillary melting point apparatus.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

et al. 2017

Self Cite

View full text Add to dashboard Cite

A series of new pyrazolo[3,4-d]pyrimidine compounds were synthesized in excellent yields via sulfuration and 1,3-dipolar cycloaddition and confirmed by MS, FT-IR and NMR techniques. All the prepared compounds were screened in vitro for their α-amylase and αglucosidase inhibitory activities. Preliminary results indicated that some target compounds exhibited promising α-amylase and α-glucosidase inhibitory activity potency. Among the tested products, the cycloadduct f was found most active inhibitor (IC50 = 134.30 μM) for αamylase, and the sulphur product b is the most active inhibitor (IC50 = 16.37 μM) for αglucosidase.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives

Fal¹,

Ramli

Zerzouf

et al. 2015

Journal of Chemistry

Self Cite

View full text Add to dashboard Cite

New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR,13C, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains:Staphylococcus aureus,Enterococcus faecalis,Escherichia coli, andPseudomonas aeruginosa. Compounds having an ethyl group showed the best activity with MIC value of 31.25 µg/mL againstStaphylococcus aureusandStreptococcus fasciens.

show abstract

Crystal structure of 1-methyl-4-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine

Cited by 2 publications

References 11 publications

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives

Contact Info

Product

Resources

About