Crystal structure of a 1:1 salt of 4-aminobenzoic acid (vitamin B<sub>10</sub>) with pyrazinoic acid

Drozd, Ksenia V.; Arkhipov, Sergey G.; Boldyreva, Elena V.; Perlovich, German L.

doi:10.1107/s2056989018016663

Cited by 9 publications

(2 citation statements)

References 29 publications

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“…Para-aminobenzoic acid or known as 4-aminobenzoic acid (PABA), as shown in Figure 1, is a vitamin commonly used as the main ingredient in the sunscreen product due to its ability to absorb ultraviolet (Drozd et al, 2018;Singh et al, 2021). However, PABA has side effects, including photoallergic and allergic contact dermatitis (DeLeo, 2018).…”

Section: Introductionmentioning

confidence: 99%

Host-Guest Sensing Interactions of Calixarene-Entrapped Para-Aminobenzoic Acid Using the Langmuir Technique

Wong,

Supian,

Abd Karim

et al. 2023

JSML

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Calixarenes are frequently studied as the host supramolecule in drug carrier applications. The ability to encapsulate and control drug delivery is due to their unique structures with a hydrophobic upper rim and a hydrophilic lower rim. Para-aminobenzoic acid (PABA) is a drug used as the main ingredient in sunscreen products with photoallergic contact dermatitis effects. This study has been motivated by the necessity of developing a PABA sensor even at a deficient concentration. In this work, the uses of two calixarenes, calix[4]arene (C4) and calix[6]arene (C6), in entrapping the PABA drug have been studied using the Langmuir technique. In the Langmuir-Blodgett trough, calixarenes in solution form were prepared and spread on the subphase to form the Langmuir monolayer. The formation of Langmuir films by C4 and C6 has been investigated based on the surface pressure-area ( - ) isotherm and surface potential-area ( - ) isotherm recorded using Langmuir apparatus KSV 2000 System 2. The differences and changes of the isotherms with the presence of para-aminobenzoic acid (PABA) in the subphase during the formation of Langmuir films have been observed and studied. The interactions between calixarenes and PABA have been shown by the effective dipole moment ( ) of the calixarene-PABA complexes calculated based on the results using the Helmholtz equation. Host-guest interaction shown by the sensing of PABA by calixarenes happens most probably at the lower rim of calixarenes due to the amphiphilic property of calixarenes. The findings of this study can be applied to the potential application of drug sensors using C4 and C6.

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Section: Introductionmentioning

confidence: 99%

Host-Guest Sensing Interactions of Calixarene-Entrapped Para-Aminobenzoic Acid Using the Langmuir Technique

Wong,

Supian,

Abd Karim

et al. 2023

JSML

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“…It is also used to darken grey hair, prevent hair loss, make skin look younger and prevent sunburn and therefore known as an ultraviolet sun screen that is applied to the skin as sun lotions 6 . It is widely used as a therapeutic agent such as an antioxidant, antibacterial, antimutagenic, anticoagulant and fibrinolytic 7,8 . The 4-carboxyaniline is considered a protective drug against UV-irradiation which could donate and also accept hydrogen through both the amine and carboxylic acid functional groups 9 .…”

Section: Introductionmentioning

confidence: 99%

Solution Growth and Characterization of 4-Carboxyanilinium Tartrate Single Crystal

Muthuselvi,

Abirami,

Priya

2022

Trends Appl. Sci. Res

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Background and Objective:The organic compound of 4-carboxyaniline has UV absorption and antifibrotic properties. It was naturally found in Streptomyces griseus, Synechococcus elongatus and other organisms. In this study, an effort was made to the growth of the 4-carboxyaniline derivative crystal with tartaric acid using the solution growth technique. Materials and Methods: The 4-carboxyanilinium tartrate crystal was grown from a slow evaporation technique in an aqueous ethanol solution at room temperature. The grown crystal was characterized by single crystal XRD, powder XRD, FT-IR, FT-Raman, UV-visible spectroscopy, SEM with EDX and antibacterial activity studies. Result: The monoclinic crystal system and P2 1 space group was confirmed from the single crystal XRD study. The diffraction peaks were indexed using INDX software. The average crystalline size was determined as 55 nm. All the wavenumber assignments were exactly matched with recently reported corresponding compounds. From the optical absorbance data, the band gap was determined as 3.75 eV using Tauc's plot. The well-defined shape of the crystal was confirmed by the SEM micrographs. Bacillus subtilis and Acinetobacter baumannii exhibited the highest zone of inhibition towards the grown crystal than Escherichia coli. Conclusion: The finding result of this study supports the previous knowledge of the structural and biological assortment of 4-carboxyanilium tartrate complex crystals.

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Crystal growth, structural, hirshfeld surface analysis of Dl-2 aminobutanoate tartrate single crystal

Balu,

Devendrapandi,

Sumithra Devi

et al. 2023

J Mater Sci: Mater Electron

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Crystal structure of a 1:1 salt of 4-aminobenzoic acid (vitamin B₁₀) with pyrazinoic acid

Abstract: The paper reports the crystal structure of novel salt of 4-aminobenzoic acid (Vitamin B10) with pyrazinoic acid.

Cited by 9 publications

References 29 publications

Host-Guest Sensing Interactions of Calixarene-Entrapped Para-Aminobenzoic Acid Using the Langmuir Technique

Host-Guest Sensing Interactions of Calixarene-Entrapped Para-Aminobenzoic Acid Using the Langmuir Technique

Solution Growth and Characterization of 4-Carboxyanilinium Tartrate Single Crystal

Crystal growth, structural, hirshfeld surface analysis of Dl-2 aminobutanoate tartrate single crystal

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Crystal structure of a 1:1 salt of 4-aminobenzoic acid (vitamin B10) with pyrazinoic acid

Abstract: The paper reports the crystal structure of novel salt of 4-amino­benzoic acid (Vitamin B10) with pyrazinoic acid.

Cited by 9 publications

References 29 publications

Host-Guest Sensing Interactions of Calixarene-Entrapped Para-Aminobenzoic Acid Using the Langmuir Technique

Host-Guest Sensing Interactions of Calixarene-Entrapped Para-Aminobenzoic Acid Using the Langmuir Technique

Solution Growth and Characterization of 4-Carboxyanilinium Tartrate Single Crystal

Crystal growth, structural, hirshfeld surface analysis of Dl-2 aminobutanoate tartrate single crystal

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Product

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Crystal structure of a 1:1 salt of 4-aminobenzoic acid (vitamin B₁₀) with pyrazinoic acid

Abstract: The paper reports the crystal structure of novel salt of 4-aminobenzoic acid (Vitamin B10) with pyrazinoic acid.