Crystal Structure of Thermus thermophilus Δ1-Pyrroline-5-carboxylate Dehydrogenase

Inagaki, E.; Ohshima, Noriyasu; Takahashi, Hitomi; Kuroishi, Chizu; Yokoyama, Shigeyuki; Tahirov, T.H.

doi:10.1016/j.jmb.2006.07.048

Cited by 54 publications

(93 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results indicated a predominantly hexameric arrangement. This is consistent with previous structural data describing a hexameric conformation (25), suggesting that TcP5CDH exists as an oligomer. The enzyme bound to mitochondrial membranes exhibited either a hexameric conformation or a protein super-complex arrangement compatible with a dimer of hexamers.…”

Section: Discussionsupporting

confidence: 93%

“…1A) and Ser 340 ) enzymes, in which the specific residues are likely to be involved in catalytic processes, as reported previously in archaea and human orthologs (Fig. 1A) (25,66).…”

Section: Identification and In Silico Analysis Of Tcp5cdh-a 1686-bpsupporting

confidence: 76%

“…Structural studies have reported different oligomeric states for P5CDHs (25)(26)(27). In archaea, P5CDH forms a homohexamer in its ligand-free form (25).…”

Section: Discussionmentioning

confidence: 99%

“…In the case of Zea mays, these enzymes appear to be bound to the mitochondrial inner membrane (21). In addition, structural studies have revealed that these types of enzymes undergo oligomerization that can vary from two to six protomers (25)(26)(27).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion of Trypanosoma cruzi

Mantilla

Paes

Pral

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

“…1A) and Ser 340 ) enzymes, in which the specific residues are likely to be involved in catalytic processes, as reported previously in archaea and human orthologs (Fig. 1A) (25,66).…”

Section: Identification and In Silico Analysis Of Tcp5cdh-a 1686-bpsupporting

confidence: 76%

“…Structural studies have reported different oligomeric states for P5CDHs (25)(26)(27). In archaea, P5CDH forms a homohexamer in its ligand-free form (25).…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion of Trypanosoma cruzi

Mantilla

Paes

Pral

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…UreG functions as a chaperone in the urease active site assembly and is often required to complete the biosynthesis of nickel-enzymes (Zambelli et al, 2009). Pyrroline-5-carboxylate dehydrogenase plays a key role in the metabolic pathway, as it catalyzes the oxidation of proline to glutamate in the presence of NAD (Inagaki et al, 2006;Parsons et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Antigenic Proteins of Helicobacter pylori of Potential Diagnostic Value

Khalilpour

Agilan²,

Lee³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Helicobacter pylori antigen was prepared from an isolate from a patient with a duodenal ulcer. Serum samples were obtained from culture-positive H. pylori infected patients with duodenal ulcers, gastric ulcers and gastritis (n=30). As controls, three kinds of sera without detectable H. pylori IgG antibodies were used: 30 from healthy individuals without history of gastric disorders, 30 from patients who were seen in the endoscopy clinic but were H. pylori culture negative and 30 from people with other diseases. OFF-GEL electrophoresis, SDS-PAGE and Western blots of individual serum samples were used to identify protein bands with good sensitivity and specificity when probed with the above sera and HRP-conjugated anti-human IgG. Four H. pylori protein bands showed good (≥ 70%) sensitivity and high specificity (98-100%) towards anti-Helicobacter IgG antibody in culturepositive patients sera and control sera, respectively. The identities of the antigenic proteins were elucidated by mass spectrometry. The relative molecular weights and the identities of the proteins, based on MALDI TOF/ TOF, were as follows: CagI (25 kDa), urease G accessory protein (25 kDa), UreB (63 kDa) and proline/pyrroline-5-carboxylate dehydrogenase (118 KDa). These identified proteins, singly and/or in combinations, may be useful for diagnosis of H. pylori infection in patients.

show abstract

Knocking down a putativeΔ¹-pyrroline-5-carboxylate dehydrogenasegene by RNA interference inhibits flight and causes adult lethality in the Colorado potato beetleLeptinotarsa decemlineata(Say)

Wan

Lü

et al. 2014

Pest. Manag. Sci.

View full text Add to dashboard Cite

show abstract

Crystal Structure of Thermus thermophilus Δ1-Pyrroline-5-carboxylate Dehydrogenase

Cited by 54 publications

References 28 publications

Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion of Trypanosoma cruzi

Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion of Trypanosoma cruzi

Antigenic Proteins of Helicobacter pylori of Potential Diagnostic Value

Knocking down a putativeΔ¹-pyrroline-5-carboxylate dehydrogenasegene by RNA interference inhibits flight and causes adult lethality in the Colorado potato beetleLeptinotarsa decemlineata(Say)

Contact Info

Product

Resources

About

Crystal Structure of Thermus thermophilus Δ1-Pyrroline-5-carboxylate Dehydrogenase

Cited by 54 publications

References 28 publications

Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion of Trypanosoma cruzi

Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion of Trypanosoma cruzi

Antigenic Proteins of Helicobacter pylori of Potential Diagnostic Value

Knocking down a putativeΔ1-pyrroline-5-carboxylate dehydrogenasegene by RNA interference inhibits flight and causes adult lethality in the Colorado potato beetleLeptinotarsa decemlineata(Say)

Contact Info

Product

Resources

About

Knocking down a putativeΔ¹-pyrroline-5-carboxylate dehydrogenasegene by RNA interference inhibits flight and causes adult lethality in the Colorado potato beetleLeptinotarsa decemlineata(Say)