Crystal structure of [tris(pyridin-2-ylmethyl)amine-κ<sup>4</sup><i>N</i>]copper(II) bromide

Bridgman, Emma C.; Doherty, Megan M.; Ellis, Kaleigh A.; Homer, Elizabeth A.; Lashbrook, Taylor N.; Mraz, Margaret E.; Pernesky, Gina C.; Vreeke, Emma M.; Oshin, Kayode D.; Oliver, Allen G.

doi:10.1107/s2056989016007568

Cited by 3 publications

(2 citation statements)

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“…This condition is frequently observed in this kind of coordination complexes. 14 Usually, in the copper(II) complexes where the distortion of the The two pyridines are twisted with respect to each other, and form a dihedral angle of 30.4(1)°. As previously hypothesized, the N-phenylethyl residue does not influence the chiral space around the metal-chelating center.…”

Section: Articlementioning

confidence: 99%

Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(ii)-catalyzed asymmetric Henry reaction

et al. 2018

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Section: Articlementioning

confidence: 99%

Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(ii)-catalyzed asymmetric Henry reaction

et al. 2018

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“…For each modelled structure, larger than desired residual electron density peaks remain after refinement of the data, which is typical for this class of compounds. 48, 49 The origin of these densities can be attributed to various factors 49 , but in the present structures, it can be attributed to the additional disorders especially in 8 . Initially, two occupancies were refined freely to identify possible site pairings, but the modelling of multiple occupancies of these disorders was not completely possible with available data.…”

Section: Methodsmentioning

confidence: 60%

A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation

et al. 2018

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Interests in inorganic applications of triazines is growing. In this report, metal complexes of copper(II), nickel(II), and zinc(II) and a novel class of chelates comprising a triazine ring substituted with a hydrazine group and pyralozone are evaluated using spectrophotometric methods, single crystal X-ray diffractometry, and electrochemistry. Complexes with copper(II) include a single chelate and two chloride atoms to satisfy a trigonal bipryamidal coordination sphere. The nickel(II) and zinc(II) complexes are comprised of two chelating groups that adopt an octahedral geometry around the metal ion. Irreversible redox activity was observed with the copper(II) complex but no redox activity was observed with the ligand alone or zinc(II) and nickel(II) complexes. Use of the coumarin carboxylic acid assay shows that the ligand motif is capable of preventing redox cycling of copper in biological conditions and could thus serve as an antioxidant preventative agent. Cellular toxicity studies show that the new triazine molecule could have therapeutic applications in the µM concentration range based on the measured EC=1.183±2 mM. Altogether this work shows that by merging triazine chemistry into inorganic compounds, there is potential to explore a range applications thanks to the new architecture.

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Investigation of cobalt(iii)–phenylalanine complexes for hypoxia-activated drug delivery

et al. 2020

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Crystal structure of [tris(pyridin-2-ylmethyl)amine-κ⁴N]copper(II) bromide

Abstract: The complex [tris(pyridin-2-ylmethyl)amine]copper(II) bromide adopts a trigonal–bipyramidal coordination geometry about the CuII ion. The outer sphere bromine counter-ions are severely disordered.

Cited by 3 publications

References 16 publications

Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(ii)-catalyzed asymmetric Henry reaction

Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(ii)-catalyzed asymmetric Henry reaction

A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation

Investigation of cobalt(iii)–phenylalanine complexes for hypoxia-activated drug delivery

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Crystal structure of [tris(pyridin-2-ylmethyl)amine-κ4N]copper(II) bromide

Abstract: The complex [tris­(pyridin-2-ylmeth­yl)amine]­copper(II) bromide adopts a trigonal–bipyramidal coordination geometry about the CuII ion. The outer sphere bromine counter-ions are severely disordered.

Cited by 3 publications

References 16 publications

Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(ii)-catalyzed asymmetric Henry reaction

Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(ii)-catalyzed asymmetric Henry reaction

A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation

Investigation of cobalt(iii)–phenylalanine complexes for hypoxia-activated drug delivery

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Product

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Crystal structure of [tris(pyridin-2-ylmethyl)amine-κ⁴N]copper(II) bromide

Abstract: The complex [tris(pyridin-2-ylmethyl)amine]copper(II) bromide adopts a trigonal–bipyramidal coordination geometry about the CuII ion. The outer sphere bromine counter-ions are severely disordered.