Crystal violet combined with Merocyanine 540 for the ex vivo purging of hematopoietic stem cell grafts

Miyagi, Kiyoko; Sampson, Reynée W.; Sieber‐Blum, Maya; Sieber, Fritz

doi:10.1016/s1011-1344(03)00073-3

Cited by 13 publications

(15 citation statements)

References 33 publications

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“…Particularly, cells with either induced or transfected MDR have been tested for cross resistance with PDT, however these results have been conflicting. Some cells resistant to chemotherapy were found to be slightly more susceptible to PDT [52, 246, 247]. In general, about one third of the reports showed cross resistance to PDT in chemotherapy, radiotherapy and hyperthermia resistant cells, whereas the rest of the models showed no resistance.…”

Section: Cross-resistance Between Pdt and Other Therapiesmentioning

confidence: 99%

Mechanisms of Resistance to Photodynamic Therapy

Casas¹,

Venosa²,

Hasan³

et al. 2011

CMC

286

215

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Photodynamic therapy (PDT) involves the administration of a photosensitizer (PS) followed by illumination with visible light, leading to generation of reactive oxygen species. The mechanisms of resistance to PDT ascribed to the PS may be shared with the general mechanisms of drug resistance, and are related to altered drug uptake and efflux rates or altered intracellular trafficking. As a second step, an increased inactivation of oxygen reactive species is also associated to PDT resistance via antioxidant detoxifying enzymes and activation of heat shock proteins. Induction of stress response genes also occurs after PDT, resulting in modulation of proliferation, cell detachment and inducing survival pathways among other multiple extracellular signalling events. In addition, an increased repair of induced damage to proteins, membranes and occasionally to DNA may happen. PDT-induced tissue hypoxia as a result of vascular damage and photochemical oxygen consumption may also contribute to the appearance of resistant cells. The structure of the PS is believed to be a key point in the development of resistance, being probably related to its particular subcellular localization. Although most of the features have already been described for chemoresistance, in many cases, no cross-resistance between PDT and chemotherapy has been reported. These findings are in line with the enhancement of PDT efficacy by combination with chemotherapy. The study of cross resistance in cells with developed resistance against a particular PS challenged against other PS is also highly complex and comprises different mechanisms. In this review we will classify the different features observed in PDT resistance, leading to a comparison with the mechanisms most commonly found in chemo resistant cells.

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Section: Cross-resistance Between Pdt and Other Therapiesmentioning

confidence: 99%

Mechanisms of Resistance to Photodynamic Therapy

Casas¹,

Venosa²,

Hasan³

et al. 2011

CMC

286

215

View full text Add to dashboard Cite

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“…The lower efficacy of crystal violet in tumour cell lines has been remedied by the co-application of the anionic photosensitiser, merocyanine 540 (Miyagi et al 2003).…”

Section: Structure and Photoproperties In Triarylmethanesmentioning

confidence: 99%

Triarylmethanes and Xanthenes

Wainwright

2009

Photosensitisers in Biomedicine

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“…Ex vivo PDT has been proven capable of eliminating the residual tumor cells in auto‐HSCT with little side effects (Hrkal, Grebenova & Cajthamlova, 2002; Anderson et al. , 2003; Miyagi et al. , 2003; Kuzelova et al.…”

Section: Introductionmentioning

confidence: 99%

Purging efficacy of ZnPcH₁‐based photodynamic therapy on chronic myeloid leukemia bone marrow

Huang

Chen

et al. 2011

Int J Lab Hematology

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Crystal violet combined with Merocyanine 540 for the ex vivo purging of hematopoietic stem cell grafts

Cited by 13 publications

References 33 publications

Mechanisms of Resistance to Photodynamic Therapy

Mechanisms of Resistance to Photodynamic Therapy

Triarylmethanes and Xanthenes

Purging efficacy of ZnPcH₁‐based photodynamic therapy on chronic myeloid leukemia bone marrow

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Crystal violet combined with Merocyanine 540 for the ex vivo purging of hematopoietic stem cell grafts

Cited by 13 publications

References 33 publications

Mechanisms of Resistance to Photodynamic Therapy

Mechanisms of Resistance to Photodynamic Therapy

Triarylmethanes and Xanthenes

Purging efficacy of ZnPcH1‐based photodynamic therapy on chronic myeloid leukemia bone marrow

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Purging efficacy of ZnPcH₁‐based photodynamic therapy on chronic myeloid leukemia bone marrow