Crystalline light chain proximal tubulopathy with chronic renal failure and silicone gel breast implants: 1 case report

Figuères, Marie-Lucile; Beaume, Julie Morinière; Vuiblet, Vincent; Rabant, Marion; Bassilios, Nader; Herody, M.; Touchard, Guy; Nôël, Laure-Hélène

doi:10.1016/j.humpath.2014.10.008

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Kidney biopsy revealed LCPT, with an appearance of osmotic nephrosis on light microscopy. These atypical histological findings have been previously reported [ 6 ] (Fig. 1 ).…”

Section: Case Reportsupporting

confidence: 85%

Loss of tubular creatinine secretion as the only sign of tubular proximal cell dysfunction in light chain proximal tubulopathy

Stehlé¹,

Vignon

Flamant

et al. 2016

Medicine

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Light chain proximal tubulopathy (LCPT) is a rare disease, characterized by cytoplasmic inclusions of light chain (usually kappa) immunoglobulins. Clinical presentation is usually a Fanconi syndrome. The proximal tubular dysfunction can be incomplete, and exceptional cases of LCPT without any tubular dysfunction have even been described. Here, we report a case of LCPT in which the only sign of proximal tubulopathy is the absence of secretion of creatinine, as assessed by the simultaneous measurement of renal clearance of creatinine and 51CrEDTA. The loss of tubular creatinine secretion as a sign of tubular proximal cell dysfunction ought to be identified in patients with light chain proximal tubulopathy as it leads to a clinically relevant underestimation of GFR by the creatinine-derived equations. The prevalence and prognostic significance of this particular proximal tubular damage in LCPT remain to be determined.

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“…Kidney biopsy revealed LCPT, with an appearance of osmotic nephrosis on light microscopy. These atypical histological findings have been previously reported [ 6 ] (Fig. 1 ).…”

Section: Case Reportsupporting

confidence: 85%

Loss of tubular creatinine secretion as the only sign of tubular proximal cell dysfunction in light chain proximal tubulopathy

Stehlé¹,

Vignon

Flamant

et al. 2016

Medicine

Self Cite

View full text Add to dashboard Cite

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“…Immunoelectron microscopy is traditionally known to be effective in detecting microbial pathogens [ 60 ]. In addition, in renal diseases such as monoclonal gammopathy, immunoelectron microscopic analysis provides useful information for diagnosis [ 61 , 62 ]. In cultured cell as well as tissue diagnosis, immunoelectron microscopic analysis provides significant intracellular information, which cannot be obtained using a light microscope [ 63 ].…”

Section: Protein Detection Methodsmentioning

confidence: 99%

Exploring Protein–Protein Interaction in the Study of Hormone-Dependent Cancers

Miki

Iwabuchi

Ono

et al. 2018

IJMS

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Estrogen receptors promote target gene transcription when they form a dimer, in which two identical (homodimer) or different (heterodimer) proteins are bound to each other. In hormone-dependent cancers, hormone receptor dimerization plays pivotal roles, not only in the pathogenesis or development of the tumors, but also in the development of therapeutic resistance. Protein–protein interactions (PPIs), including dimerization and complex formation, have been also well-known to be required for proteins to exert their functions. The methods which could detect PPIs are genetic engineering (i.e., resonance energy transfer) and/or antibody technology (i.e., co-immunoprecipitation) using cultured cells. In addition, visualization of the target proteins in tissues can be performed using antigen–antibody reactions, as in immunohistochemistry. Furthermore, development of microscopic techniques (i.e., electron microscopy and confocal laser microscopy) has made it possible to visualize intracellular and/or intranuclear organelles. We have recently reported the visualization of estrogen receptor dimers in breast cancer tissues by using the in situ proximity ligation assay (PLA). PLA was developed along the lines of antibody technology development, and this assay has made it possible to visualize PPIs in archival tissue specimens. Localization of PPI in organelles has also become possible using super-resolution microscopes exceeding the resolution limit of conventional microscopes. Therefore, in this review, we summarize the methodologies used for studying PPIs in both cells and tissues, and review the recently reported studies on PPIs of hormones.

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Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond

Picken¹,

Doğan²

2015

Current Clinical Pathology

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Crystalline light chain proximal tubulopathy with chronic renal failure and silicone gel breast implants: 1 case report

Cited by 5 publications

References 11 publications

Loss of tubular creatinine secretion as the only sign of tubular proximal cell dysfunction in light chain proximal tubulopathy

Loss of tubular creatinine secretion as the only sign of tubular proximal cell dysfunction in light chain proximal tubulopathy

Exploring Protein–Protein Interaction in the Study of Hormone-Dependent Cancers

Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond

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