“…In classic CF, lung involvement is the major cause of mortality, dominated by recurrent infections and airway obstruction, finally leading to respiratory failure (Marcorelles et al, 2014). CF is caused by a mutation in the CF transmembrane conductance Regulator gene ( CFTR ; MIM# 602421; GenBank NM 000492.3) which codes for a transmembrane Cl − and HCO 3 − channel (Choi et al, 2001; Ontalus et al, 1996). CFTR gene is located on human chromosome 7, contains 27 exons and generates a 6.4 kb messenger RNA (mRNA; Gregory et al, 1990).…”