“…Binary solvent mixtures are commonly used in industrial crystallizations and recently more research on more complex multiphase crystallization processes with liquid-liquid phase separation (LLPS) have been reported. Liquid-liquid equilibrium data have been investigated for some "anti-solvent" crystallization experiments [2,3], spherical crystallizations using a three solvents system [4,5], oiling out phenomena [6][7][8][9][10] and reverse addition processes [11]. The LLPS makes crystallization difficult in protein systems [12,13], prevents drug nucleation [14][15][16], and hinders nucleation in crystallization of droplets [17].…”