CSF Anomalies in Children Affected by Epilepsia Partialis Continua (EPC)

Gaggero, R.; Ferraris, P.; Negri, M. De

doi:10.1055/s-2008-1071482

Cited by 5 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So far, the presence of antibody synthesis in the CSF compartment has not been studied systematically, and the finding of OBs in the CSF of patients with epilepsy is limited to single cases in the literature [23,24]. In our present work, intrathecal immunoglobulin synthesis was determined by oligoclonal IgG bands and IgM/IgA antibody serum/CSF indices, and was present in 34.1% of all patients with epilepsy.…”

Section: Discussionmentioning

confidence: 57%

High frequency of intrathecal immunoglobulin synthesis in epilepsy so far classified cryptogenic

Kowski

Volz

Holtkamp

et al. 2013

Euro J of Neurology

View full text Add to dashboard Cite

Humoral immune activation in the CSF compartment was detected in one-third of patients with epilepsy, besides acute symptomatic seizures particularly frequent in cryptogenic epilepsy--an etiology so far defined as not having a detectable cause. Systematic prospective clinical and experimental trials are required to identify antigenic targets and select appropriate patients for which immunotherapy might offer new causal therapeutic options.

show abstract

Section: Discussionmentioning

confidence: 57%

High frequency of intrathecal immunoglobulin synthesis in epilepsy so far classified cryptogenic

Kowski

Volz

Holtkamp

et al. 2013

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…Rasmussen encephalitis is the prototype of epileptic syndromes in which an immunopathogenesis is presumed, and reported favorable responses to immunomodulatory treatment support this hypothesis (reviewed in Billiau et al, 2005; Vezzani and Granata, 2005). Our Rasmussen patient showed high‐titer antinuclear antibodies, elevated total IgG and intrathecal oligoclonal Ig synthesis, which have previously been described (Andrews et al, 1990; Gaggero et al, 1990), but failed to respond and experienced the typical dramatic deterioration (Oguni et al, 1991). Some authors have reported that the clinical success rate of IVIG was higher in patients with IgA or IgG2 deficiency, although many other studies have refuted these associations (Ariizumi et al, 1983; Duse et al, 1986; Rijckevorsel‐Harmant et al, 1986; van Rijckevorsel‐Harmant and Delire, 1988; Spina et al, 1989; Illum et al, 1990; Sterio et al, 1990; Echenne et al, 1991; Rijckevorsel‐Harmant et al, 1994; van Engelen et al, 1994d).…”

Section: Discussionmentioning

confidence: 99%

Intravenous Immunoglobulins in Refractory Childhood‐Onset Epilepsy: Effects on Seizure Frequency, EEG Activity, and Cerebrospinal Fluid Cytokine Profile

Billiau

Witters²,

Ceulemans³

et al. 2007

Epilepsia

View full text Add to dashboard Cite

Summary:Purpose: Several studies have reported favorable effects of intravenous immunoglobulins (IVIG) in refractory epilepsy. Evidence substantiating an immunomodulatory action is scarce. In an open-label study, we prospectively investigated the effect of IVIG on clinical, EEG and serum/CSF immunological parameters in patients with refractory childhood-onset epilepsy.Methods: Thirteen patients (median age 6.9 years; range 1.6-25.8) with refractory seizures despite 3-4 antiepileptic drug regimens were given IVIG (Sandoglobulin, ZLB-Behring, add-on, 4 × 400 mg/kg/3 weeks). Seizure frequency, 24-h video-EEG, and CSF/serum immunological parameters and cytokine profiles (IL-6/IL-8/IL-12/IL-10) were documented before and after completion of the course.Results: Seizure frequency was reduced by ≥50% in four, and by 25%-50% in three patients. In contrast, variation in automatically recorded spike counts (1-h-wake and -sleep) did not correlate with clinical improvement. Serum immunological parameters showed variable deviations in eight patients (e.g., IgG 2 deficiency) and CSF immunoblotting showed oligoclonal bands in two patients. Blood-brain barrier permeability was normal in 12 patients. IL-6 and IL-8 were clearly detectable in CSF of all patients; the levels were significantly higher than those in plasma but remained unaffected by IVIG treatment.Conclusions: Despite unchanged EEG spike counts, substantial reductions in seizure frequency occurred in 7 of 13 patients, suggesting that IVIG hinder progression of central epileptic activity into clinical seizures. Intrathecal presence of IL-8 and IL-6 was documented in all patients, but was unaffected by IVIG, suggesting that their production is directly related to electrical seizure activity and that IVIG may act through interference with immune pathways downstream to IL-6 and IL-8.

show abstract

Natural killer cell activity and serum immunoglobulins in epileptic patients

Testorell¹,

Pruneri

Ferini‐Strambi

et al. 1993

Human Psychopharmacology

View full text Add to dashboard Cite

Serum immunoglobulins and the activity of natural killer (NK) cells of 50 epileptic patients (eight with idiopathic generalized epilepsy and 42 with cryptogenic partial epilepsy) and 28 controls have been studied. The values of IgA, IgG and IgM were the same in patients and controls. The NK activity in controls was linearly related to the effector-to-target ratio, but this linear relationship was not observed in epileptic patients. The cytotoxic activity of NK cells at the lowest effector-to-target ratio was significantly greater in patients than in controls. This increase was observed in each therapy group. Our results seem to confirm a disturbance of the immune system in epileptic patients and suggest that this modification of cellular immunity is not a drug effect but is related to the illness itself.

show abstract

CSF Anomalies in Children Affected by Epilepsia Partialis Continua (EPC)

Cited by 5 publications

References 3 publications

High frequency of intrathecal immunoglobulin synthesis in epilepsy so far classified cryptogenic

High frequency of intrathecal immunoglobulin synthesis in epilepsy so far classified cryptogenic

Intravenous Immunoglobulins in Refractory Childhood‐Onset Epilepsy: Effects on Seizure Frequency, EEG Activity, and Cerebrospinal Fluid Cytokine Profile

Natural killer cell activity and serum immunoglobulins in epileptic patients

Contact Info

Product

Resources

About