CT-Based Diagnosis of Low Vertebral Bone Mineral Density Is Associated with Hypercalciuria and Hypocitraturia on Opportunistic Imaging

Patel, Nishant; Ward, Ryan D.; Calle, Juan; Remer, Eric; Monga, Manoj

doi:10.1089/end.2018.0296

Cited by 5 publications

(12 citation statements)

References 30 publications

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“…In fact, patients with urolithiasis have a high occurrence rate of hypercalciuria, up to 50% reported in the literature [ 23 ]. Unlike the results of previous reports from Europe and the United States [ 9 , 24 ], our cohort had only 8.6% hypercalciuria in both men and women but had a higher prevalence of hypocitraturia. Similar to our study cohort, a Japanese cohort also had a lower prevalence of hypercalciuria [ 18 ].…”

Section: Discussioncontrasting

confidence: 97%

“…Furthermore, we found that urinary citrate excretion was positively associated with T-scores in men and premenopausal women with urolithiasis. Citrate is considered to decrease with acidosis under circumstances of increasing bone resorption; therefore, patients with urolithiasis with osteopenia or osteoporosis tend to have hypocitraturia [ 24 , 31 ]. In fact, some papers indicated that potassium citrate treatment reversed low BMD [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Low bone mineral density is a potential risk factor for symptom onset and related with hypocitraturia in urolithiasis patients: a single-center retrospective cohort study

et al. 2020

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Background Patients with urolithiasis have a lower bone mineral density (BMD) than those without stones, suggesting a potential correlation between calcium stone formation and bone resorption disorders, including osteopenia and osteoporosis. Methods To investigate the influence of BMD on clinical outcomes in urolithiasis, we performed a single-center retrospective cohort study to analyze patients with urolithiasis who underwent both BMD examination and 24-h urine collection between 2006 and 2015. Data from the national cross-sectional surveillance of the Japanese Society on Urolithiasis Research in 2015 were utilized, and additional data related to urinary tract stones were obtained from medical records. The primary outcome was the development of stone-related symptoms and recurrences during follow-up. A total of 370 patients were included in this 10-year study period. Results Half of the patients had recurrent stones, and the two-thirds were symptomatic stone formers. While only 9% of patients had hypercalciuria, 27% and 55% had hyperoxaluria and hypocitraturia, respectively. There was a positive correlation between T-scores and urinary citrate excretion. Both univariate and multivariate analyses demonstrated that female sex was associated with recurrences (odds ratio = 0.44, p = 0.007), whereas a T-score < − 2.5 and hyperoxaluria were associated with symptoms (odds ratio = 2.59, p = 0.037; odds ratio = 0.45, p = 0.01; respectively). Conclusion These results revealed that low T-scores might cause symptoms in patients with urolithiasis, suggesting the importance of BMD examination for high-risk Japanese patients with urolithiasis having hypocitraturia.

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Section: Discussioncontrasting

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Low bone mineral density is a potential risk factor for symptom onset and related with hypocitraturia in urolithiasis patients: a single-center retrospective cohort study

et al. 2020

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“…In fact, patients with urolithiasis have a high occurrence rate of hypercalciuria, up to 50% reported in the literature [22]. Unlike the results of previous reports from Europe and the United States [9,23], our cohort had only 8.6% hypercalciuria in both men and women but had a higher prevalence of hypocitraturia. Similar to our study cohort, a Japanese cohort also had a lower prevalence of hypercalciuria [17].…”

Section: Discussioncontrasting

confidence: 74%

“…Citrate is considered to decrease with acidosis under circumstances of increasing bone resorption; therefore, patients with urolithiasis with osteopenia or osteoporosis tend to have hypocitraturia [23,30]. In fact, some papers indicated that potassium citrate treatment reversed low BMD [31,32].…”

Section: Discussionmentioning

confidence: 99%

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Taguchi

Hamamoto

Okada

et al. 2020

Preprint

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Background: Patients with urolithiasis have a lower bone mineral density (BMD) than those without stones, suggesting a potential correlation between calcium stone formation and bone resorption disorders, including osteopenia and osteoporosis. Methods: To investigate the influence of BMD on clinical outcomes in urolithiasis, we performed a single-center retrospective cohort study to analyze patients with urolithiasis who underwent both BMD examination and 24-hour urine collection between 2006 and 2015. Data from the national cross-sectional surveillance of the Japanese Society on Urolithiasis Research in 2015 were utilized, and additional data related to urinary tract stones were obtained from medical records. The primary outcome was the development of stone-related symptoms and recurrences during follow-up. A total of 370 patients were included in this 10-year study period. Results: Half of the patients had recurrent stones, and the two-thirds were symptomatic stone formers. While only 9% of patients had hypercalciuria, 27% and 55% had hyperoxaluria and hypocitraturia, respectively. There was a positive correlation between T-scores and urinary citrate excretion. Both univariate and multivariate analyses demonstrated that female sex was associated with recurrences (odds ratio=0.44, p=0.007), whereas a T-score <−2.5 and hyperoxaluria were associated with symptoms (odds ratio=2.59, p=0.037; odds ratio=0.45, p=0.01; respectively). Conclusion: These results revealed that low T-scores might cause symptoms in patients with urolithiasis, suggesting the importance of BMD examination for high-risk Japanese patients with urolithiasis having hypocitraturia.

show abstract

“…Citrate is considered to decrease with acidosis under circumstances of increasing bone resorption; therefore, patients with urolithiasis with osteopenia or osteoporosis tend to have hypocitraturia [24,31]. In fact, some papers indicated that potassium citrate treatment reversed low BMD [32,33].…”

Section: Discussionmentioning

confidence: 99%

Low bone mineral density is a potential risk factor for symptom onset and related with hypocitraturia in urolithiasis patients: A single-center retrospective cohort study

Taguchi

Hamamoto

Okada

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Patients with urolithiasis have a lower bone mineral density (BMD) than those without stones, suggesting a potential correlation between calcium stone formation and bone resorption disorders, including osteopenia and osteoporosis. Methods To investigate the influence of BMD on clinical outcomes in urolithiasis, we performed a single-center retrospective cohort study to analyze patients with urolithiasis who underwent both BMD examination and 24-hour urine collection between 2006 and 2015. Data from the national cross-sectional surveillance of the Japanese Society on Urolithiasis Research in 2015 were utilized, and additional data related to urinary tract stones were obtained from medical records. The primary outcome was the development of stone-related symptoms and recurrences during follow-up. A total of 370 patients were included in this 10-year study period. Results Half of the patients had recurrent stones, and the two-thirds were symptomatic stone formers. While only 9% of patients had hypercalciuria, 27% and 55% had hyperoxaluria and hypocitraturia, respectively. There was a positive correlation between T-scores and urinary citrate excretion. Both univariate and multivariate analyses demonstrated that female sex was associated with recurrences (odds ratio=0.44, p=0.007), whereas a T-score <��

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CT-Based Diagnosis of Low Vertebral Bone Mineral Density Is Associated with Hypercalciuria and Hypocitraturia on Opportunistic Imaging

Abstract: CT-based diagnosis of low mineral bone density is associated with derangement in 24-hour urine calcium and citrate in KSFs, as well as larger stone volumes.

Cited by 5 publications

References 30 publications

Low bone mineral density is a potential risk factor for symptom onset and related with hypocitraturia in urolithiasis patients: a single-center retrospective cohort study

Low bone mineral density is a potential risk factor for symptom onset and related with hypocitraturia in urolithiasis patients: a single-center retrospective cohort study

Low Bone Mineral Density is a Potential Risk Factor for Symptom Onset and Related with Hypocitraturia in Urolithiasis Patients: A Single-Center Retrospective Cohort Study

Low bone mineral density is a potential risk factor for symptom onset and related with hypocitraturia in urolithiasis patients: A single-center retrospective cohort study

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