CT evaluation of anaplastic thyroid carcinoma.

Takashima, S; Morimoto, S; Ikezoe, Junpei; Takai, Shin‐ichiro; Kobayashi, Tetsuro; Koyama, H; Nishiyama, Kinji; Kozuka, T

doi:10.2214/ajr.154.5.2108546

Cited by 78 publications

(46 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A mass suspected of being ATC can be evaluated with an MRI scan to determine the locoregional extent of disease. CT scanning of the neck and mediastinum can help to define extent of disease and identify tumor invasion of great vessels and the upper aerodigestive tract [5]. Alternatively, ultrasonography of the neck can be used to identify local and regional nodes and spread.…”

Section: Imagingmentioning

confidence: 99%

Anaplastic thyroid carcinoma: An overview

Cornett

Sharma²,

Day³

et al. 2007

Curr Oncol Rep

View full text Add to dashboard Cite

Thyroid cancer is an uncommon malignancy that accounts for roughly 1% of all new cancers. Although anaplastic lesions constitute fewer than 5% of thyroid cancers, they represent over half of thyroid cancer-related deaths. The relative rarity of anaplastic thyroid cancer, its aggressive nature, and its rapidly fatal course have contributed to the difficulty in developing effective treatment for this disease. Radiation, chemotherapy, and surgery are rarely curative, but combinations of these modalities appear to offer greater benefit than any single treatment. New treatment modalities are desperately required, and promising molecular-based therapies are being investigated.

show abstract

Section: Imagingmentioning

confidence: 99%

Anaplastic thyroid carcinoma: An overview

Cornett

Sharma²,

Day³

et al. 2007

Curr Oncol Rep

View full text Add to dashboard Cite

show abstract

“…With sonography, anaplastic carcinomas are diffusely hypoechoic, with areas of necrosis in 78 % of cases, dense amorphous calcifications in 58 % and nodal or distant metastases in 80 % [7,21]. Furthermore, even more diagnostically useful, sonographic signs of this cancer are marked irregularities of the boundaries and the early invasion of thyroid gland capsule, with infiltration of adjacent structures (Fig.…”

Section: Nodular Diseasesmentioning

confidence: 99%

Ultrasound of thyroid, parathyroid glands and neck lymph nodes

Solbiati

Osti²,

Cova³

et al. 2001

Eur Radiol

215

133

View full text Add to dashboard Cite

In the past 15 years high-frequency B-mode sonography and colour-power Doppler have become the most important and most widely employed imaging modalities for the study of the neck, in particular for thyroid gland, parathyroids and lymph nodes. Sonography allows not only the detection but often also the characterization of the diseases of these organs, distinguishing benign from malignant lesions with high sensitivity and specificity, which could be further improved by the employ of ultrasound contrast agents and harmonic imaging. Although no single sonographic criterion is specific for benign or malignant nature of the lesions, the combination of different signs can be markedly helpful to speed up the diagnostic process. Fine-needle aspiration biopsy (FNAB) remains the most accurate modality for the definitive assessment of thyroid gland nodules and of any doubtful case of nodal disease. In association with clinical findings and serum levels of parathormone, FNAB has specificity close to 100% for the characterization of parathyroid adenomas. A combined approach with sonography and FNAB is generally highly effective.

show abstract

“…In a study of 15,700 patients with thyroid cancer in the United States, the overall 10-year relative survival rate, corrected for age and sex, was 13% for anaplastic disease (9). The median survival time after diagnosis is 3 to 7 months, and a worse prognosis is associated with large tumors, distant metastasis, acute obstructive symptoms, and leukocytosis (10,11). Despite the widespread use of multimodality treatment, survival rates have not improved much in the past few decades (12,13).…”

Section: Introductionmentioning

confidence: 99%

Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer

Younes¹,

Kim²,

Yigitbasi³

et al. 2005

Molecular Cancer Therapeutics

View full text Add to dashboard Cite

We investigated integrin-linked kinase (ILK), a focal adhesion serine-threonine protein kinase, as a new molecular target for treating anaplastic thyroid cancer. ILK mediates cell growth and survival signals and is overexpressed in a number of cancers. Therefore, we hypothesized that inhibition of ILK leads to growth arrest and apoptosis of thyroid cancer cells. According to Western blotting, the level of ILK protein was highly expressed in one papillary (NPA187) and four of five (Hth74, DRO, ARO, KAT4, and K4) anaplastic thyroid cancer cell lines. Immunohistochemical analysis of a human tissue microarray revealed that ILK was highly expressed in anaplastic thyroid cancer but not in normal human thyroid tissue. Treating thyroid cancer cell lines with a new ILK inhibitor, QLT0267, inhibited epidermal growth factor -induced phosphorylation of AKT, inhibited cell growth, and induced apoptosis in the NPA187, DRO, and K4 cell lines. QLT0267 also inhibited the kinase activity of immunoprecipitated ILK in four of five cell lines. Tumor volumes in mice treated with QLT0267 were significantly reduced compared with those in untreated mice. In immunohistochemical studies, QLT0267 suppressed phosphorylated p-AKT and angiogenesis (i.e., reduced mean vascular density) and induced apoptosis in both tumor cells and tumor-associated endothelial cells of the thyroid DRO xenografts. In summary, we found that ILK expression and activity were elevated in human anaplastic thyroid cancer and ILK inhibition led to growth arrest and apoptosis in vitro and in vivo. Our results provide preliminary evidence that ILK is a potential therapeutic target for treating anaplastic thyroid cancer.

show abstract

CT evaluation of anaplastic thyroid carcinoma.

Cited by 78 publications

References 9 publications

Anaplastic thyroid carcinoma: An overview

Anaplastic thyroid carcinoma: An overview

Ultrasound of thyroid, parathyroid glands and neck lymph nodes

Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer

Contact Info

Product

Resources

About