CT fluoroscopy-guided closed-tip catheter placement before regional hyperthermia treatment of soft tissue sarcomas: 5-Year experience in 35 consecutive patients

Strobl, Frederik F.; Azam, Houman; Schwarz, Jens B.; Paprottka, Philipp; Geith, Tobias; Abdel-Rahman, S.; Zilles, Benjamin; Lindner, Lars H.; Reiser, Maximilian; Trumm, C.

doi:10.3109/02656736.2015.1107761

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…The whole catheter implementation was performed under periodical single-shot CT fluoroscopic acquisitions only. Further details about the CT fluoroscopy in RHT are described by Strobl et al [10]. The procedure of the catheter invasive placement was carried out by a board-certified radiologist with an experience of over 5 years in CT-guided interventions.…”

Section: Implementation Of Tumor Cathetersmentioning

confidence: 99%

“…The minimal-invasive thermometry in the pelvic tumors was as effective as invasive thermal monitoring [9]. The use of invasive catheters in the tumor is relatively time-consuming and can be associated with potential risks such as hemorrhages, infections, acute side effects, and a low acceptance by patients and physicians [10]. Nonetheless, many clinical studies reported that interstitially measured temperatures correlate well with clinical endpoints [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Regional deep hyperthermia: quantitative evaluation of predicted and direct measured temperature distributions in patients with high-risk extremity soft-tissue sarcoma

Aklan

Zilles

Paprottka³

et al. 2019

International Journal of Hyperthermia

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Background: Temperature distributions resulting from hyperthermia treatment of patients with highrisk soft-tissue sarcoma (STS) were quantitatively evaluated and globally compared with thermal simulations performed by a treatment planning system. The aim was to test whether the treatment planning system was able to predict correct temperature distributions. Methods: Five patients underwent computed tomography (CT) fluoroscopy-guided placement of tumor catheters used for the interstitial temperature measurements. For the simulations, five 3 D patient models were reconstructed by segmenting the patient CT datasets into different tissues. The measured and simulated data were evaluated by calculating the temperature change (DT), T90, T50, T20, T mean , T min and T max , as well as the 90th percentile thermal dose (CEM43T90). In order to measure the agreement between both methods quantitatively, the Bland-Altman analysis was applied. Results: The absolute difference between measured and simulated temperatures were found to be 2 , 6 , 1 , 4 , 5 and 4 C on average for T min , T max , T90, T50, T20 and T mean , respectively. Furthermore, the thermal simulations exhibited relatively higher thermal dose compared to those that were measured. Finally, the results of the Bland-Altman analysis showed that the mean difference between both methods was above 2 C which is considered to be clinically unacceptable. Conclusion: Given the current practical limitations on resolution of calculation grid, tissue properties, and perfusion information, the software SigmaHyperPlan TM is incapable to produce thermal simulations with sufficient correlation to typically heterogeneous tissue temperatures to be useful for clinical treatment planning.

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Section: Implementation Of Tumor Cathetersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regional deep hyperthermia: quantitative evaluation of predicted and direct measured temperature distributions in patients with high-risk extremity soft-tissue sarcoma

Aklan

Zilles

Paprottka³

et al. 2019

International Journal of Hyperthermia

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“…The treating temperature of target tissue should be 41–46 °C to destroy the cancer cells while avoiding the harm on normal cells [3]. To prevent treating temperature to a higher value, a thermometry probe contacting with target tissue is always needed [4, 5]. However, this method is harmful when tumor is inside the body.…”

Section: Introductionmentioning

confidence: 99%

LSMO Nanoparticles Coated by Hyaluronic Acid for Magnetic Hyperthermia

et al. 2016

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Magnetic hyperthermia with the treating temperature range of 41–46 °C is an alternative therapy for cancer treatment. In this article, lanthanum strontium manganates (La1−xSrxMnO3, 0.25 ≤ × ≤ 0.35) magnetic nanoparticles coated by hyaluronic acid (HA) which possesses the ability of targeting tumor cells were prepared by a simple hydrothermal method combined with a high-energy ball milling technique. The crystal structure, morphology, magnetic properties of the HA-coated magnetic nanoparticles (MNPs), and their heating ability under alternating magnetic field were investigated. It was found the HA-coated La0.7Sr0.3MnO3, with particle diameter of ~100 nm, Curie temperature of 45 °C at a concentration 6 mg/ml, gave the optimal induction heating results. The heating temperature saturates at 45.7 °C, and the ESAR is 5.7 × 10−3 W/g · kHz · (kA/m2) which is much higher than other reported results.Electronic supplementary materialThe online version of this article (doi:10.1186/s11671-016-1756-3) contains supplementary material, which is available to authorized users.

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