CT imaging features of skeletal muscle metastasis

Ong, Nicodemus; George, Mathew; Dutta, Rupak; Ng, Chee Hui

doi:10.1016/j.crad.2018.12.017

Cited by 16 publications

(18 citation statements)

References 10 publications

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“…8 This imposes great diagnostic difficulties comprising various differential diagnoses and treatment planning. 8 However, in imaging studies, most patients have already other metastases and, consequently, a tumour stage 4, 2,6 which is in agreement with the present patient sample. These differences are caused by asymptomatic lesions in imaging studies, compared to symptomatic lesions presented to the surgeon.…”

Section: Discussionsupporting

confidence: 90%

“…According to the previous reports, lung cancer was identified as most frequent primary tumour in patients with SMM ranging from 25.2% to 40% 2,4,8 However, in a recent single-centre study, breast cancer was most prevalent tumour with the reported frequency of 25%. 6 Yet, in the present study, breast cancer was only identified in few patients. Presumably, the wide range of primary tumours is caused by patient selection bias and different local tumour incidences.…”

Section: Primary Tumourscontrasting

confidence: 58%

“…4 To date, only few studies investigated imaging features of SMM. 2,[4][5][6][7][8] Moreover, it is a very heterogeneous disease entity due to different primary tumours, localizations and imaging appearances. Therefore, to better understand this rare tumour entity, there is a need of more patient cohorts.…”

Section: Introductionmentioning

confidence: 99%

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CT imaging features of skeletal muscle metastasis: A rare tumour group with different patterns

2020

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Introduction: Skeletal muscle metastasis (SMM) are rare and can have different patterns on computed tomography (CT). Our aim was to estimate the frequency of the different patterns, primary tumours and localizations of SMM in a large single-centre sample. Methods: A retrospective search in the database of our radiological institution was performed for patients with SMM. The primary tumour, affected muscles and CT patterns were estimated. Results: Overall, 104 SMM were diagnosed in 82 patients. In 11 patients (13.4%), SMM were the isolated manifestation of metastatic disease in clinical work up. Regarding primary tumours, gastrointestinal tumours (24.4%), lung cancer (20.4%) and malignant melanoma (13.4%) were identified most frequently. Other malignancies were rare. Most commonly, the trunk musculature was affected (41.3% of the cases). SMM type 1 were identified in 37 cases (35.6%), type 2 in 64 cases (61.5%), type 3 in 2 cases (1.9%) and type 4 in one case (1%). Conclusions: The present study shows typical imaging appearances of SMM based on a large patient sample in a single centre. SMM has a rare occurrence with several different patterns, which can impose diagnostic difficulties and varies possible differential diagnoses.

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Section: Discussionsupporting

confidence: 90%

Section: Primary Tumourscontrasting

confidence: 58%

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CT imaging features of skeletal muscle metastasis: A rare tumour group with different patterns

2020

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“…If STM is diagnosed after detection of the primary tumor, the prognosis is relatively good, and this may be attributed to the aggressiveness and speed of tumor invasion. Although many case reports on STM are available, these are limited to < 10 cases [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Previous reports have shown that primary tumors are more common in lung cancer, and histologic types are more common in adenocarcinoma; our study demonstrated the same results.…”

Section: Discussionsupporting

confidence: 81%

“…Metastases from carcinomas usually present at regional lymph nodes and other organs including the liver and lung; the soft tissue is an uncommon site for metastasis owing to specific homeostatic conditions that suppress tumor cell proliferation, constant trauma to cells due to muscle contraction, lactic acid production by the skeletal muscle, and high tumor cell permeability [3]. Although various case reports and series have been reported with regard to soft tissue metastasis (STM) of cancer, large-scale studies are lacking [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. In addition, most of the previous reports have only considered their clinical trends and diagnostic methods to distinguish them from soft tissue sarcoma, and few studies have examined prognostic factors.…”

Section: Introductionmentioning

confidence: 99%