CT imaging of myocardial scars with collagen-targeting gold nanoparticles

Danila, Delia; Johnson, Evan M.; Kee, Patrick

doi:10.1016/j.nano.2013.03.009

Cited by 68 publications

(39 citation statements)

References 59 publications

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“…In small animal models visualization has been achieved by quantum dots for fluorescent imaging, radionuclide imaging and computed tomographic (CT) imaging [106, 112, 113]. In addition, optoacoustic imaging could be a potential tool to not only follow the location and amount of injectate in vivo, but also to provide a noninvasive method to measure the mechanical strength of the injected material and the myocardium [114, 115].…”

Section: New Strategies In Materials Designmentioning

confidence: 99%

Ventricular wall biomaterial injection therapy after myocardial infarction: Advances in material design, mechanistic insight and early clinical experiences

2017

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Intramyocardial biomaterial injection therapy for myocardial infarction has made significant progress since concept initiation more than 10 years ago. The interim successes and progress in the first 5 years have been extensively reviewed. During the last 5 years, two phase II clinical trials have reported their long term follow up results and many additional biomaterial candidates have reached preclinical and clinical testing. Also in recent years deeper investigations into the mechanisms behind the beneficial effects associated with biomaterial injection therapy have been pursued, and a variety of process and material parameters have been evaluated for their impact on therapeutic outcomes. This review explores the advances made in this biomaterial-centered approach to ischemic cardiomyopathy and discusses potential future research directions as this therapy seeks to positively impact patients suffering from one of the world’s most common sources of mortality.

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Section: New Strategies In Materials Designmentioning

confidence: 99%

Ventricular wall biomaterial injection therapy after myocardial infarction: Advances in material design, mechanistic insight and early clinical experiences

2017

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“…Gold nanoparticles have also been used for CT imaging of lymph nodes by targeting CD4 (Eck et al 2010), imaging of inflammation by targeting intravascular E-selectin (Wyss et al 2009), imaging of atherosclerosis by targeting fibrin (Winter et al 2005), imaging of myocardial scars by targeting collagen (Danila et al 2013), and imaging of other cardiovascular disease (Ghann et al 2012). In addition to targeting by the surface conjugation of a ligand, some nanoparticles have inherent targeting abilities due to their nanoparticle chemistry.…”

Section: Micro-ct With Active Targetingmentioning

confidence: 99%

Small Animal X-ray Computed Tomography

Badea¹

2017

Handbook of X-Ray Imaging

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“…2) (36). Similarly, targeted nanoparticles have been used for CT imaging of structures such atherosclerotic plaques (37), thrombi (38), and myocardial scars (39), although the sensitivity of nanoparticle-enhanced CT imaging remains on the low side for many molecular imaging applications.…”

Section: Design Versatility: Multimodal and Multifunctional Imaging Amentioning

confidence: 99%

Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features

Stendahl

Sinusas

2015

J Nucl Med

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Imaging agents made from nanoparticles are functionally versatile and have unique properties that may translate to clinical utility in several key cardiovascular imaging niches. Nanoparticles exhibit size-based circulation, biodistribution, and elimination properties different from those of small molecules and microparticles. In addition, nanoparticles provide versatile platforms that can be engineered to create both multimodal and multifunctional imaging agents with tunable properties. With these features, nanoparticulate imaging agents can facilitate fusion of high-sensitivity and high-resolution imaging modalities and selectively bind tissues for targeted molecular imaging and therapeutic delivery. Despite their intriguing attributes, nanoparticulate imaging agents have thus far achieved only limited clinical use. The reasons for this restricted advancement include an evolving scope of applications, the simplicity and effectiveness of existing small-molecule agents, pharmacokinetic limitations, safety concerns, and a complex regulatory environment. This review describes general features of nanoparticulate imaging agents and therapeutics and discusses challenges associated with clinical translation. A second, related review to appear in a subsequent issue of JNM highlights nuclear-based nanoparticulate probes in preclinical cardiovascular imaging.

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CT imaging of myocardial scars with collagen-targeting gold nanoparticles

Cited by 68 publications

References 59 publications

Ventricular wall biomaterial injection therapy after myocardial infarction: Advances in material design, mechanistic insight and early clinical experiences

Ventricular wall biomaterial injection therapy after myocardial infarction: Advances in material design, mechanistic insight and early clinical experiences

Small Animal X-ray Computed Tomography

Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features

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