CT Manifestations and Clinical Characteristics of 1115 Patients with Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-analysis

Abstract

Rationale and Objectives: We aimed to assess the prevalence of significant computed tomographic(CT) manifestations and describe some notable features based on chest CT images, as well as the main clinical features of patients with coronavirus disease 2019(COVID-19). Materials and Methods: A systematic literature search of PubMed, EMBASE, the Cochrane Library, and Web of Science was performed to identify studies assessing CT features, clinical, and laboratory results of COVID-19 patients. A single-arm meta-analysis was conducted to obtain the pooled prevalence and 95% confidence interval (95% CI). Results: A total of 14 articles (including 1115 patients) based on chest CT images were retrieved. In the lesion patterns on chest CTs, we found that pure ground-glass opacities (GGO) (69%, 95% CI 58À80%), consolidation (47%, 35À60%) and "air bronchogram sign" (46%, 25À66%) were more common than the atypical lesion of "crazy-paving pattern" (15%, 8À22%). With regard to disease extent and involvement, 70% (95% CI 46À95%) of cases showed a location preference for the right lower lobe, 65% (58À73%) of patients presented with 3 lobes involvement, and meanwhile, 42% (32À53%) of patients had involvement of all five lobes, while 67% (55À78%) of patients showed a predominant peripheral distribution. An understanding of some important CT features might be helpful for medical surveillance and management. In terms of clinical features, muscle soreness (21%, 95% CI 15À26%) and diarrhea (7%, 4À10%) were minor symptoms compared to fever (80%, 74À87%) and cough (53%, 33À72%). Conclusion: Chest CT manifestations in patients with COVID-19, as well as its main clinical characteristics, might be helpful in disease evolution and management.

Thorax Magnetic Resonance Imaging Findings in Patients with Coronavirus Disease (COVID-19)

“…Various findings can be seen in the lung parenchyma in COVID-19 infection (15). The most common of these is the ground-glass appearance, defined as an increase in fog-shaped density in which the walls of the vessels and bronchi are not wiped (16,17). It develops due to mild interstitial thickening or air loss within the airways (18).…”

Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans

“…Many patients who are hospitalized due to COVID-19 get multiple chest CT scans depending on the clinical progression. There are a few series in the literature that have demonstrated how evolution of thoracic imaging findings happen [2,11,20]. In spite of the commonly observed chest imaging findings associated with COVID-19, reports of abdominal imaging findings are limited.…”

“…Older age, comorbidities including hypertension, diabetes, cardiovascular disease, respiratory disease, and laboratory examinations such as white blood cells (WBC), aspartate aminotransferase (AST), creatinine, lactate dehydrogenase (LDH), and d-dimer have been reported to imply the progression of COVID-19 [9,10]. Chest CT findings have been shown to be associated with severe or critical COVID-19 pneumonia as well as with the different stages of the disease [11,12]. Although the involvement of the respiratory system is common, liver injury may occur especially in patients with severe COVID-19 [13].…”

Correlation Between Low-Dose Chest Computed Tomography and RT-PCR Results for the Diagnosis of COVID-19: A Report of 27,824 Cases in Tehran, Iran

“…Pulmonary involvement of COVID-19 predominantly manifest as subpleural ground glass opacities and consolidation. Early identification of typical CT findings provides timely diagnostic evidence of the disease and enables early decision-making and treatment ( 16 , 17 ). In this study, we observed a strong positive correlation between number of daily positive CT scans and daily PCR-confirmed COVID-19 cases.…”