CT of Pulmonary Epithelioid Hemangioendothelioma

Luburich, Patricio; Ayuso, M. C.; Picado, César; Serra-Batllés, Joan; Ramírez, José; Solé, Manel

doi:10.1097/00004728-199407000-00010

Cited by 41 publications

(32 citation statements)

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“…The thoracic CT usually reveal more nodules that those in the chest radiography. In long-standing cases, extensive calcification of the nodules and insterstitial involvement can be seen [9].…”

Section: Case Reportmentioning

confidence: 99%

Central nervous system metastases of a pulmonary epitheloid haemangioendothelioma

Díaz

Segura²,

Calderero³

et al. 2004

Eur Respir J

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Central nervous system metastases of a pulmonary epitheloid haemangioendothelioma. R. Díaz, Á. Segura, V. Calderero, I. Cervera, J. Aparicio, M.V. Jordá, L. Pellín. #ERS Journals Ltd 2004. ABSTRACT: The case of a 55-yr-old male with a right pleural effusion and multiple bilateral nodules is reported. A diagnostic thoracothomy was necessary to obtain a definitive histological diagnosis.During the postoperative course, the subject9s neurological condition deteriorated and multiple cerebral mass lesions were discovered. The pathological analysis of both lung and cerebral tumours revealed an atypical endothelial cell proliferation; vascular immunohistochemical markers, such as factor VIII and CD34, were strongly positive. His general condition remained poor and the patient died 18 months after the initial diagnosis.The final diagnosis was pulmonary epitheloid haemangioendothelioma with synchronous central nervous system dissemination, the first time the authors believe that association has been reported. Little is known of the prognosis and treatment of these tumours, due to their rarity. Negative prognostic factors appear to be the presence of symptoms, pleural effusion or multifocal presentations. Treatment should include surgical resection if possible; chemotherapy appears to have little effect. Watchful waiting is an acceptable option, especially in asymptomatic patients.

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Section: Case Reportmentioning

confidence: 99%

Central nervous system metastases of a pulmonary epitheloid haemangioendothelioma

Díaz

Segura²,

Calderero³

et al. 2004

Eur Respir J

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“…Pleural effusion is reportedly uncommon [2]. CT has been reported to show multiple nodules which are more than initially anticipated with a perivascular distribution, irregular margins, and foci of calcification [13]. Though the possibility that small nodules were not scanned by chance could not be denied, this case presented as a solitary pulmonary…”

Section: Discussionmentioning

confidence: 67%

Metastatic Pulmonary Epithelioid Hemangioendothelioma with Peculiar Radiographic Features

Nagata

Takatsu²,

Y³

et al. 1999

Respiration

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We report a case of a pulmonary epithelioid hemangioendothelioma presenting as a solitary pulmonary nodule with subsequent systemic spread, including histologically documented gingival metastasis. Chest radiography and computed tomography at initial evaluation showed a solitary 2 cm pulmonary nodule, associated with pleural indentation and vascular convergence. The tumor later spread systemically, including multiple pulmonary nodules, bilateral pleural effusions, and gingival swelling and erosion. A biopsy of the gingival lesion showed histologic features identical to that of the lung biopsy.

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“…It is a solid tumour of low-grade malignancy, composed of epithelioid-appearing endothelial cells [2,3]. It should not be confused with infantile haemangioendothelioma, which regresses spontaneously and usually presents before 6 months of age [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with pulmonary epithelioid haemangioendothelioma (PEH) are usually non-symptomatic or have non-specific symptoms such as dyspnoea, cough or chest pain [2,3,7]. Hepatomegaly, splenomegaly and ascites are often seen in hepatic EHE [6].…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance imaging (MRI) of the liver confirmed the presence of multiple nodular lesions with a predominantly peripheral location, hypointense relative O. Ghekiere 1 · B. Weynand 2 · T. Pieters 3 · E. Coche 1 ( ✉ ) Departments of 1 Radiology, 2 Pathology, 3 1 High-resolution CT of the lungs shows peripheral areas of ground-glass opacities associated with some interlobular thickening. These findings were bilateral and predominant in both lower lobes to the liver parenchyma on enhanced T1-weighted images and with a high intensity on T2-weighted sequences.…”

Section: Imaging Findingsmentioning

confidence: 99%

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Epithelioid haemangioendothelioma (2004:3b)

Ghekiere

Weynand²,

Pieters³

et al. 2004

European Radiology

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Part 1Case history A 55-year-old Algerian woman presented in January 2001 with a dry cough and joint pain. She had never smoked and was not on medication. Her medical history was unremarkable apart from tuberculosis of the spine at 3 years of age. On examination, she had palpable oedema. She was treated with AINS (Diclofenac 100 mg) with significant improvement, but 1 day later she complained of dyspnoea grade I-II. Physical examination revealed painful clubbing of the fingernails and skin dryness. Both lung and heart sounds were normal. The oxygen saturation was 98% while the patient was breathing ambient air. Laboratory tests revealed a mild inflammatory syndrome with a C-reactive protein (CRP) level of 5.7 mg/dl. The erythrocyte sedimentation rate was 46 mm/h. Renal function was within normal limits. Tumour markers (NSE, CEA, AFP and Ca 19-9) were negative.Pulmonary function tests were performed and showed a total lung capacity (TLC) of 3.5 l (64% of the predicted value) and a forced expiratory volume at 1 s (FEV1) of 69% of the predicted value; forced vital capacity (FVC) of 65%; FEV1/FVC of 77%; and carbon monoxide diffusing capacity of 84%. Findings were consistent with a mild restrictive pattern.High-resolution CT of the chest (Fig. 1), early arterial enhanced CT (Fig. 2) and delayed enhanced MR of the abdomen (Fig. 3) were performed.Broncho-alveolar lavage fluid cell count showed 88% macrophages, 10% lymphocytes, 2% neutrophils and no malignant cells.

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CT of Pulmonary Epithelioid Hemangioendothelioma

Cited by 41 publications

References 0 publications

Central nervous system metastases of a pulmonary epitheloid haemangioendothelioma

Central nervous system metastases of a pulmonary epitheloid haemangioendothelioma

Metastatic Pulmonary Epithelioid Hemangioendothelioma with Peculiar Radiographic Features

Epithelioid haemangioendothelioma (2004:3b)

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