Metastatic Pulmonary Epithelioid Hemangioendothelioma with Peculiar Radiographic Features

Nagata, Nobuhiko; Takatsu, Hiroyuki; Y, Sato; Yoshimatsu, Takashi; Urabe, Michita; Kido, Masamitsu

doi:10.1159/000029343

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…A Medline search was performed to collect data on previously published cases of PEH and 13 authors in Japan, Belgium and USA were contacted to obtain full patient data. In this review, we studied the data of 93 patients, 4–64 including our patient by Cox regression analysis using forward stepwise method (SPSS version 9, SPSS, Chicago, IL, USA) to identify the risk factors and the independent predictors of survival in patients with PEH.…”

Section: Review Of the Literaturementioning

confidence: 99%

Risk factors and independent predictors of survival in patients with pulmonary epithelioid haemangioendothelioma. Review of the literature and a case report

Amin

Hiroshima

Kokubo³

et al. 2006

Respirology

100

105

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Pulmonary epithelioid haemangioendothelioma (PEH) is a rare pulmonary neoplasm. A patient with PEH with lymph node and pleural metastases that were discovered incidentally is described. An abnormal left upper lobe shadow was noticed on CXR in a 70-year-old woman during an assessment for the sudden onset of nausea and vomiting. Transbronchial lung biopsy did not provide a diagnosis. Lobectomy and lymph node resection were performed. The histological diagnosis of PEH was confirmed immunohistochemically by positive reactions to factor VIII-related antigen and CD34. Data on 93 patients with PEH including the present case report were analysed by Cox regression analysis using forward stepwise method to identify the risk factors, and the independent predictors of survival in patients with PEH. It revealed that male, symptomatic patients, presence of cough, haemoptysis, chest pain, multiple unilateral nodules, pleural effusion, metastases to more than one site and lymph node metastases were all significant risk factors for PEH (P<0.05). Symptomatic patients and presence of pleural effusion were the independent predictors of survival in patients with PEH.

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Section: Review Of the Literaturementioning

confidence: 99%

Risk factors and independent predictors of survival in patients with pulmonary epithelioid haemangioendothelioma. Review of the literature and a case report

Amin

Hiroshima

Kokubo³

et al. 2006

Respirology

100

105

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“…[1][2][3][4][5] More than 90% of the reported cases in Japan show this feature. 2 Another usual appearance is a solitary pulmonary nodule measuring up to 5cm, which is seen in less than 10% of the cases in Japan.…”

Section: Discussionmentioning

confidence: 99%

High Resolution CT Findings of Pulmonary Epithelioid Hemangioendothelioma

Sakamoto¹,

Adachi²,

Monzawa³

et al. 2005

Journal of Thoracic Imaging

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Pulmonary epithelioid hemangioendotheliomas (PEH), also known as intravascular sclerosing bronchoalveolar tumor, is a rare vascular tumor of the lung common among young women. Primitive lumena lined by single cells is the characteristic pathologic feature. The endothelial nature of these cells is confirmed by positive staining with factor VIII and CD34. PEH usually presents as single or multiple pulmonary nodules. The present report describes high resolution CT (HRCT) findings of 2 cases with unusual manifestations of PEH. One case was a 54-year-old woman with multiple pulmonary nodules with irregular thickening of both the bronchovascular bundles and perilobular structures, representing intensive lymphangitic spread on HRCT. The other was an 18-year-old woman who had multiple minute peripheral nodules in the lungs bilaterally. These HRCT findings demonstrated the presence of tumor nodules in the lymphatic spaces, which is quite an unusual histologic presentation for this tumor. Both cases also showed hepatic lesions on abdominal CT; the former showing hypoattenuating masses with coarse calcifications and the latter showing multiple tiny calcifications in the hepatic parenchyma. Recognition of these features in the appropriate clinical setting may allow the clinician and the pathologist to consider this rare tumor.

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“…Nahezu jede Lokalisation von epithelioiden Hämangioendotheliomen wurde beschrieben: neben relativ häufigen Lokalisationen wie Bindegewebe [12,20], Knochen [1,16,18,19,21,36,38,40,43], Leber [17] und Lunge [3,14,15,23,42] auch seltenere wie Haut [11,20,28], Milz [4,35], Gehirn [7,25], Darm und Omentum [27,29] und große Gefäße [9,37]. Über die Häufigkeit von epithelioiden Hämangioendotheliomen im Knochen finden sich keine genauen Angaben.…”

Section: Lokalisation Und Vorkommenunclassified

“…einem Fünftel der Fälle beschrieben [1,2,13,16,38]; die Prognose der Erkrankung scheint dadurch nicht verschlechtert zu sein. Während früher in der Literatur die Fähigkeit des epithelioiden Häman-gioendothelioms zur Metastasierung überwiegend verneint wurde, häufen sich in letzter Zeit Berichte über metastasierende epithelioide Hämangioendo-theliome mit fatalem Ausgang [23,33].…”

Section: Lokalisation Und Vorkommenunclassified