CT-scan is a valuable tool to detect mandibular involvement in oral cancer patients

Handschel, Jörg; Naujoks, Christian; Depprich, Rita; Kübler, Norbert R.; Kröpil, Patric; Kuhlemann, J.; Jansen, T.; Boeck, Inga; Sproll, Karl Christoph

doi:10.1016/j.oraloncology.2011.11.009

Cited by 59 publications

(39 citation statements)

References 29 publications

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“…Handschel et al indicated that the sensitivity and specificity of CT scan in detecting bone involvement of oral squamous cell carcinomas were 82.6%, 86.9% and Positive predictive value and Negative predictive value were 82.6%, 86.9% respectively. (21) There were an acceptable agreement between the result of research of Handschel et al (21) and the present study. In our study and study of Handschel et al (21) The sensitivity was higher than specificity and the Positive predictive value was higher than the negative predictive value too.…”

Section: Discussionsupporting

confidence: 88%

“…(21) There were an acceptable agreement between the result of research of Handschel et al (21) and the present study. In our study and study of Handschel et al (21) The sensitivity was higher than specificity and the Positive predictive value was higher than the negative predictive value too. But sensitivity, specificity, positive predictive value and negative predictive value were less than in the Handschel et al (21) It is possibly due to lack of sufficient data about patient selection, the time transcurred of imaging tests and histopathological verification.…”

Section: Discussionsupporting

confidence: 88%

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A Comparative Study of CT Scan and MRI in The Assessment of Squamous Cell Carcinoma of The Oral Cavity and Its Cervical Lymph Node Metastasis

Koopaie

Karimi

2014

3dj

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Introduction: Squamous Cell Carcinoma (SCC) is the most common head and neck malignancy. To decrease the side effects of treatment and mortality from disease relapse, careful staging for the proper treatment plan is necessary. The main purpose of this prospective study is to compare the diagnostic value of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) in oral SCC and its lymph node metastasis in order to represent the proper treatment plan. Materials and Methods: 30 patients (19 men and 11 women) with oral SCC underwent CT and MRI before surgery. Imaging modalities of each study were evaluated individually for tumor size, bone invasion, muscle infiltration. These evaluations were done by two radiologists and an oral-maxillofacial surgeon and verified with histopathology findings as gold standard. The results of the radiological assessment were correlated with the intraoperative and histopathological findings in all patients. Results: CT and MRI have equal potential for detecting the tumor size, perineural invasion and nodal metastasis. The sensitivity and specificity were 50%, 90% for CT in the detection of bone invasion and 90%, 85% for MRI. The sensitivity and specificity were 66.66%, 90.47% for CT in detection of muscle infiltration and 55.55%, 90.47% for MRI. Conclusion:The comparison of these modalities showed no statistically significant difference between CT and MRI. Regarding bone infiltration the sensitivity of CT scan was higher than of MRI, but regarding muscle invasion the specificity of MRI was higher than of CT scan.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

A Comparative Study of CT Scan and MRI in The Assessment of Squamous Cell Carcinoma of The Oral Cavity and Its Cervical Lymph Node Metastasis

Koopaie

Karimi

2014

3dj

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“…[27][28][29][30] There are a total of 271 participants, 130 diagnosed with SCC and 141 without SCC. The technical aspects of the different imaging modalities as well as the diagnostic and validation criteria can be seen in Table 4.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…From an imaging point of view, there are discrepancies in application of the tests in these studies, such as differing slice thicknesses for CT 30 and different tesla values for MRI.…”

Section: Risk Of Bias In the Studiesmentioning

confidence: 99%

“…For CT, differences in slice thicknesses of between 1.5 mm and 6 mm were observed 27,30 as well as in amperage, with values of between 100 and 200 mAs. 29,30 Slice thickness for MRI also varied, from 3 to 6 mm. 28,29 Receiver operating characteristic (ROC) curves were not prepared because the different scales and criteria used did not permit generation/ definition of cutoff points for the different studies.…”

Section: Heterogeneity Analysismentioning

confidence: 99%

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Accuracy of imaging methods for detection of bone tissue invasion in patients with oral squamous cell carcinoma

Uribe

Rojas²,

Rosas³

2013

Dentomaxillofacial Radiology

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The objective of this review is to evaluate the diagnostic accuracy of imaging methods for detection of mandibular bone tissue invasion by squamous cell carcinoma (SCC). A systematic review was carried out of studies in MEDLINE, SciELO and ScienceDirect, published between 1960 and, in English, Spanish or German, which compared detection of mandibular bone tissue invasion via different imaging tests against a histopathology reference standard. Sensitivity and specificity data were extracted from each study. The outcome measure was diagnostic accuracy. We found 338 articles, of which 5 fulfilled the inclusion criteria. Tests included were: CT (four articles), MRI (four articles), panoramic radiography (one article), positron emission tomography (PET)/CT (one article) and cone beam CT (CBCT) (one article). The quality of articles was low to moderate and the evidence showed that all tests have a high diagnostic accuracy for detection of mandibular bone tissue invasion by SCC, with sensitivity values of 94% (MRI), 91% (CBCT), 83% (CT) and 55% (panoramic radiography), and specificity values of 100% (CT, MRI, CBCT), 97% (PET/CT) and 91.7% (panoramic radiography). Available evidence is scarce and of only low to moderate quality. However, it is consistently shown that current imaging methods give a moderate to high diagnostic accuracy for the detection of mandibular bone tissue invasion by SCC. Recommendations are given for improving the quality of future reports, in particular provision of a detailed description of the patients' conditions, the imaging instrument and both imaging and histopathological invasion criteria.

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Oral squamous carcinoma: Aggressive tumor pattern of invasion predicts direct mandible invasion

et al. 2020

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Background: Aggressive histologic worst pattern of invasion (WPOI) in surrounding soft tissue has been shown to be predictive of higher local recurrence and poorer survival in oral cavity squamous cell carcinoma (OCSCC) patients. This study investigates whether aggressive WPOI can predict the mandibular invasion phenotype. Methods: Patients consecutively diagnosed with OCSCC undergoing a mandibulectomy (marginal or segmental) between 2013 and 2018 were reviewed. Senior physicians re-reviewed radiologic scans and pathologic slides of 44 cases. Results: Aggressive WPOI (WPOI-4, 5) is significantly associated with infiltrative bone invasion. Non-aggressive WPOI (WPOI-1, 2, 3) is significantly associated with the absence of bone invasion. Conclusions: WPOI has become a useful tool that further characterizes the biologic behavior of OCSCC. Potentially, planned surgery may escalate from a marginal to segmental mandibulectomy based on aggressive WPOI for patients with radiographically uncertain cortical status. Further studies are needed to validate the relationship between OCSCC WPOI and mandible status.

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CT-scan is a valuable tool to detect mandibular involvement in oral cancer patients

Cited by 59 publications

References 29 publications

A Comparative Study of CT Scan and MRI in The Assessment of Squamous Cell Carcinoma of The Oral Cavity and Its Cervical Lymph Node Metastasis

A Comparative Study of CT Scan and MRI in The Assessment of Squamous Cell Carcinoma of The Oral Cavity and Its Cervical Lymph Node Metastasis

Accuracy of imaging methods for detection of bone tissue invasion in patients with oral squamous cell carcinoma

Oral squamous carcinoma: Aggressive tumor pattern of invasion predicts direct mandible invasion

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