Cu-bearing high-entropy alloys with excellent antiviral properties

Zhong, Li; Qiao, Dongxu; Xu, Yewei; Zhou, Enze; Yang, Chuntian; Yuan, Xinyi; Lu, Yiping; Gu, Ji‐Dong; Sand, Wolfgang; Xu, Dake; Wang, Fuhui

doi:10.1016/j.jmst.2020.12.027

Cited by 32 publications

(12 citation statements)

References 41 publications

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“…From scanning electron microscopy images, it was observed that copper could inhibit the bacteria adhesion and decrease biofilm development (Liu et al 2018 ). According to another similar research, Ti-10 Cu alloy (containing 10% Cu) showed a 75% reduction of anaerobic porphyromonas gingivalis cell members within 24 h time period (Li et al 2021 ). High entropy alloy-based material design enables the advent of innovative and advanced biomaterials (Calin et al 2021 ).…”

Section: Copper Based Materials In Fighting Covid-19 Virusmentioning

confidence: 93%

“…High entropy alloy-based material design enables the advent of innovative and advanced biomaterials (Calin et al 2021 ). Copper based high entropy alloy CuFeCrCoNi, possess good corrosion resistance, mechanical properties and antiviral activity which inactivated 99.99% of H1N1 virus in 24 h (Li et al 2021 ) indicating the effectiveness of copper ions in the surface of the alloy.…”

Section: Copper Based Materials In Fighting Covid-19 Virusmentioning

confidence: 99%

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Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

et al. 2021

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Copper (Cu) and its alloys are prospective materials in fighting covid-19 virus and several microbial pandemics, due to its excellent antiviral as well as antimicrobial properties. Even though many studies have proved that copper and its alloys exhibit antiviral properties, this research arena requires further research attention. Several studies conducted on copper and its alloys have proven that copper-based alloys possess excellent potential in controlling the spread of infectious diseases. Moreover, recent studies indicate that these alloys can effectively inactivate the covid-19 virus. In view of this, the present article reviews the importance of copper and its alloys in reducing the spread and infection of covid-19, which is a global pandemic. The electronic databases such as ScienceDirect, Web of Science and PubMed were searched for identifying relevant studies in the present review article. The review starts with a brief description on the history of copper usage in medicine followed by the effect of copper content in human body and antiviral mechanisms of copper against covid-19. The subsequent sections describe the distinctive copper based material systems such as alloys, nanomaterials and coating technologies in combating the spread of covid-19. Overall, copper based materials can be propitiously used as part of preventive and therapeutic strategies in the fight against covid-19 virus.

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Section: Copper Based Materials In Fighting Covid-19 Virusmentioning

confidence: 93%

Section: Copper Based Materials In Fighting Covid-19 Virusmentioning

confidence: 99%

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

et al. 2021

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“…It is known that the inactivation of Escherichia coli on Cu-based alloy surface is mainly due to the effect of the Cu + /Cu 2+ ion released during the oxidation process of the material [ 7 – 12 ]. As the multi-principal element alloys studied here are composed of five elements, we cannot reason that only copper is being oxidized, but the biocidal effect observed must be due mainly to the ions of this element [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

“…The survival of pathogenic microorganisms on surfaces of metallic Cu and Cu-based alloys was assessed in different studies [ 7 – 11 ], but in most cases, the Cu concentration was higher than 60 wt.% or around it. Li et al [ 12 ] studied the antiviral properties of the CuFeCrCoNi and Al 0.4 CuFeCrCoNi high-entropy alloys with lower Cu content, showing over 99.99% of efficiency under influenza H1N1 virus and enterovirus after 24 h in contact. These results were related to the interaction of copper ions, hydroxyl radicals, and microorganisms, revealing new possibilities for the application of high-entropy alloys as biocidal materials.…”

Section: Introductionmentioning

confidence: 99%

Effect of Al Content on the Microstructure and Properties of As-Cast AlxCoCrCuFe Alloys

Oliveira

Paganotti

Silva

et al. 2022

Metallogr. Microstruct. Anal.

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High-entropy alloys (HEAs) (or multi-principal component alloys) have been mentioned in different studies because they have good corrosion resistance and mechanical properties, but their biocidal ability is still little explored. The microstructural, magnetic, corrosion, and biocidal behavior of as-cast Al x CoCrCuFe high-entropy alloys with x = 0.5 and 0.9 were analyzed using scanning electron microscopy, energy-dispersive X-ray spectroscopy, magnetization measurements as a function of the applied field, X-ray diffraction patterns, electrochemical essays, and antimicrobial analyses. The results indicated that a higher concentration of Al reduces the saturation magnetization, the corrosion potential, as well as the survival time of the bacterium Escherichia coli on the surface of the studied alloys. The dendritic microstructure was also refined with the increase in the concentration of Al and a higher number of Cu-rich precipitate was observed on their surface. Graphical Abstract

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“…These events are caused by close contact with pathogens. To provide a healthy and safe environment for human beings, it is critical to develop surface contact materials that yield good antibacterial effects and can control the spread of pathogens [ 1 , 2 ]. Copper and copper alloys have attracted the attention of researchers due to their natural and efficient bactericidal ability [ 3 – 5 ].…”

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confidence: 99%

Antibacterial property, corrosion and discoloration resistance of pure copper containing Zn or Ni

Jiang

Zhang

et al. 2022

Rare Met.

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This study focused on the effects of Zn and Ni addition on the antibacterial properties and corrosion resistance of copper alloys. The antimicrobial properties of copper and copper alloys were evaluated using Escherichia coli ATCC 8739 bacterial strain by employing the overlay and plate counting methods. X-ray photoelectron spectroscopy (XPS) was used to analyze the surface composition of the alloy after contact with bacteria. A salt spray method was used to simulate an artificial sweat contact environment to test the discoloration and corrosion resistance of the alloy, and scanning electron microscopy (SEM) was used to analyze the film layer and surface material composition of the corroded samples. The addition of Ni reduced the antibacterial performance of pure copper; however, the antibacterial performance of the alloy remained fast and efficient after the addition of Zn. Moreover, the addition of Zn and Ni significantly improved the corrosion resistance and surface discoloration of copper alloys in artificial sweat environments. This study provided support for the future application of copper alloys as antimicrobial surface-contact materials with safer public and medical environments in the face of diseases spread by large populations. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s12598-022-02098-8.

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Cu-bearing high-entropy alloys with excellent antiviral properties

Cited by 32 publications

References 41 publications

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

Effect of Al Content on the Microstructure and Properties of As-Cast AlxCoCrCuFe Alloys

Antibacterial property, corrosion and discoloration resistance of pure copper containing Zn or Ni

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