Cu-catalysed transamidation of unactivated aliphatic amides

Abstract

Direct transamidation is gaining prominence as a ground-breaking technique that generates a wide variety of amides without the requirement of acid–amine coupling or other intermediate steps.

Pd NPs decorated on crosslinked sodium alginate modified iron-based metal–organic framework Fe(BTC) as a green multifunctional catalyst for the oxidative amidation

“…Amide functionalities are commonly found in a range of organic compounds, polymers, natural substances, and pharmaceuticals [1,2]. Traditional methods for synthesizing amides have several drawbacks, including the use of toxic reagents, precious metal catalysts, long reaction times, and acyl halide sources [3,4]. Therefore, the development of atom-efficient methods is essential for achieving more sustainable and environmentally friendly chemical processes.…”

“…One promising alternative for amide synthesis is the use of alcohols. Alcohols can be converted to amides through a tandem oxidation process under oxidative conditions, either in situ via carboxylic acids or aldehydes [4,5]. These oxidative amidation reactions from alcohols provide attractive pathways to reduce the consumption of organic compounds, synthetic costs, and the need for complex synthetic methods [6].…”

Transamidation of secondary carboxamides and amidation of esters are facilitated by magnetic Co@NC nanoparticles, as a highly efficient and recyclable catalyst under neat conditions

“…[4][5][6] The presence of carboxamide functional groups within diverse compounds facilitates the prevention and treatment of numerous health disorders. [7][8][9] Some drugs are shown in Fig. 1.…”