CuCeO Bimetallic Oxide Rapidly Treats Staphylococcus aureus‐Infected Osteomyelitis through Microwave Strengthened Microwave Catalysis and Fenton‐Therapy

Abstract

Osteomyelitis caused by bacteria is a deep-seated lesion and is often treated clinically with antibiotics. Long-term use of antibiotics may predispose bacteria to develop resistance. Here, CuCeO x material is applied to treat infectious bacterial osteomyelitis using microwave (MW)-assisted bacterial killing. Heat generation occurs as a result of the dielectric properties of the material under MW irradiation, and the material generates reactive oxygen species (ROS) under MW irradiation. Heat and ROS increase the thermal sensitivity and permeability of bacterial cell membranes, and the released copper ions easily penetrate the bacterial membrane and react with H 2 O 2 to produce a toxic hydroxyl group inside the bacteria, leading to the bacteria's eventual death. This is due to the synergistic effect of the MW thermal effect, ROS, and the breaking of the equilibrium within the bacteria. CuCeO x can effectively treat osteomyelitis caused by Staphylococcus aureus using MW irradiation. This study can safely and effectively address the challenge of deep tissue infections by shedding light on non-invasive antimicrobial systems and using MW thermal therapy and MW dynamics to achieve therapeutic results.

Bioclay Enzyme with Bimetal Synergistic Sterilization and Infectious Wound Regeneration

“…In hospitals and communities, antibiotics are the mainstream choice for antibacterial treatment. − However, the abuse of antibiotics has also led to the birth of drug-resistant superbugs, bringing a haze to the field of antibacterial therapies. , As a drug-free antibacterial therapy, metal ion antibacterial therapy not only avoids the generation of drug-resistant bacteria but also exhibits a variety of antibacterial mechanisms, which has attracted widespread attention from researchers. , Typically, metal ions (Fe 2+ , Cu 2+ , Mn 2+ , etc.) could catalyze hydrogen peroxide (H 2 O 2 ) into highly toxic hydroxyl radicals (·OH) through Fenton or Fenton-like reactions to kill bacteria, and Al 3+ could react with membrane phospholipids to cause damage of bacterial membrane. − Although metal ions could destroy bacteria through a variety of mechanisms, metal ion antibacterial therapy still faces many challenges, such as limited H 2 O 2 in infection microenvironment (IME), insufficient ions, and inflammatory side effects. ,, …”