Cu (II)-porphyrin metal–organic framework/graphene oxide: synthesis, characterization, and application as a pH-responsive drug carrier for breast cancer treatment

Gharehdaghi, Zahra; Rahimi, Rahmatollah; Naghib, Seyed Morteza; Molaabasi, Fatemeh

doi:10.1007/s00775-021-01887-3

Cited by 40 publications

(24 citation statements)

References 67 publications

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Section: D P‐mofs Composites/derivativesmentioning

confidence: 99%

“…The functional groups on the base materials can combine with the metal sites of 2D p-MOFs to realize the optimization of the compostite properties. Zahra Gharehdaghi et al 40 proposed a method for synthesizing 2D Cu-TCPP MOF supported on graphene oxide (GO) nanosheets. Cu-TCPP was attached to GO through the interaction between epoxy groups on GO and metal sites (Figure 3).…”

Section: Growth Of 2d P-mofs On Other Materialsmentioning

confidence: 99%

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Preparation of two‐dimensional porphyrin‐based MOFs/derivatives and their potential in sensing and biomedical applications

Wang

Zhao

et al. 2023

Interdisciplinary Medicine

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Two‐dimensional Porphyrin‐based MOFs (2D p‐MOFs) and their derivatives have demonstrated significant potential in sensing and biomedical applications with their development and optimization expected to lead to significant advances in these fields. However, achieving a high quality of 2D p‐MOFs remains the present research rub and challenge. This review covers various methods and compound strategies for preparing 2D p‐MOFs including both bottom‐up and top‐down approaches, both of which have drawbacks that need to be addressed, and also summarizes their advantages for the obtained prepared 2D p‐MOF. Meanwhile, we review the different ways of functionalizing 2D porphyrin‐based MOF nanosheets with examples. It also highlights the crucial role of 2D p‐MOFs and derivatives in sensing applications, including food safety inspection, biomedical sensing, and environmental testing. Finally, the review summarizes the medical treatment based on 2D p‐MOFs, including drug delivery, photodynamic therapy (PDT), photothermal therapy, imaging, and more, further emphasizing the value of 2D p‐MOFs and derivatives.

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Section: D P‐mofs Composites/derivativesmentioning

confidence: 99%

Section: Growth Of 2d P-mofs On Other Materialsmentioning

confidence: 99%

Preparation of two‐dimensional porphyrin‐based MOFs/derivatives and their potential in sensing and biomedical applications

Wang

Zhao

et al. 2023

Interdisciplinary Medicine

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“…Owing to their numerous advantages, Cu MOFs are suitable candidates for the development of nano-delivery platforms: I) they provide a unique broad-spectrum antibacterial effect ( Lee et al, 2021 ; Wang Z. et al, 2022 ); II) they possess the ability to stimulate endothelial cell proliferation and differentiation, thereby promoting angiogenesis by simulating hypoxia ( Dang et al, 2020 ); III) they possess an open skeleton framework and excellent chemical stability ( Liu et al, 2019 ); IV) they possess a unique near-infrared (NIR) absorption ability, which can be used to develop photo-thermal therapy (PTT) nano-drug system ( Weng et al, 2020 ; Wang L. et al, 2021 ; Geng et al, 2022 ); V) they have a favorable loading capacity and are a good choice for developing chemodynamic therapy (CDT) nanocarriers ( Hao et al, 2021b ). Recently, small-molecule drugs, such as chlorhexidine ( Soltani and Akhbari, 2022 ), DOX ( Gharehdaghi et al, 2021 ), 5-fluorouracil ( Liu W. et al, 2020 ), methotrexate ( Nezhad-Mokhtari et al, 2019 ), diclofenac sodium, chlorpromazine hydrochloride, amodiaquin dihydrochloride ( Liu et al, 2019 ), and ibuprofen ( Javanbakht et al, 2019 ), have been successfully loaded into nano-drug delivery systems through Cu MOFs. Enzymatically active molecules, such as horseradish peroxidase and glucose oxidase, can also be effectively loaded by Cu MOFs and exhibit superior stabilities than those in the free state ( Hao et al, 2021a ; Lin et al, 2021 ).…”

Section: Classification Of Mnpsmentioning

confidence: 99%

Metal-based nano-delivery platform for treating bone disease and regeneration

Liu

Xu²,

Qiao³

et al. 2022

Front. Chem.

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Owing to their excellent characteristics, such as large specific surface area, favorable biosafety, and versatile application, nanomaterials have attracted significant attention in biomedical applications. Among them, metal-based nanomaterials containing various metal elements exhibit significant bone tissue regeneration potential, unique antibacterial properties, and advanced drug delivery functions, thus becoming crucial development platforms for bone tissue engineering and drug therapy for orthopedic diseases. Herein, metal-based drug-loaded nanomaterial platforms are classified and introduced, and the achievable drug-loading methods are comprehensively generalized. Furthermore, their applications in bone tissue engineering, osteoarthritis, orthopedic implant infection, bone tumor, and joint lubrication are reviewed in detail. Finally, the merits and demerits of the current metal-based drug-loaded nanomaterial platforms are critically discussed, and the challenges faced to realize their future applications are summarized.

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“…Another problem that restricts the use of MOFs in anti-HCC treatment is drug loading and drug release ( Gharehdaghi et al, 2021 ; Jiang et al, 2021 ). The drug loading and release properties of these nanodrug delivery platforms depend on both the structure of the MOFs and the properties of the loaded drugs.…”

Section: Challenges Of Mof In Cancer Treatmentmentioning

confidence: 99%

Metal-organic frameworks for hepatocellular carcinoma therapy and mechanism

Feng

Wu²,

Li³

2022

Front. Pharmacol.

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In recent years, metal organic frameworks (MOFs) have attracted increasing attention in cancer therapy, because they can enhance the anticancer efficacy of photodynamic therapy (PDT), photothermal therapy (PTT), photoacoustic imaging, and drug delivery. Owing to stable chemical adjustability, MOFs can be used as carriers to provide excellent loading sites and protection for small-molecule drugs. In addition, MOFs can be used to combine with a variety of therapeutic drugs, including chemotherapeutics drugs, photosensitizers, and radiosensitizers, to efficiently deliver drugs to tumor tissue and achieve desired treatment. There is hardly any review regarding the application of MOFs in hepatocellular carcinoma. In this review, the design, structure, and potential applications of MOFs as nanoparticulate systems in the treatment of hepatocellular carcinoma are presented.Systematic Review Registration: website, identifier registration number

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Cu (II)-porphyrin metal–organic framework/graphene oxide: synthesis, characterization, and application as a pH-responsive drug carrier for breast cancer treatment

Cited by 40 publications

References 67 publications

Preparation of two‐dimensional porphyrin‐based MOFs/derivatives and their potential in sensing and biomedical applications

Preparation of two‐dimensional porphyrin‐based MOFs/derivatives and their potential in sensing and biomedical applications

Metal-based nano-delivery platform for treating bone disease and regeneration

Metal-organic frameworks for hepatocellular carcinoma therapy and mechanism

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