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There are different reports on the coordination mode 1,3-thiazolidine-2-thione to metals with both N and S as donor atoms. 1Interest in the coordination chemistry of the 1,3-thiazole derivatives arises from the presence of the heterocyclic skeleton in many biomolecules. 2 The crystal structure on the metal complexes of this ligand is scarce.This ligand exhibits a thiol-thione tautomerism, as shown in the following thiol-thione equilibrium (N=C-SH and -NH-C=S) [Scheme 1].3 Deprotonation in a basic media produces the thionate moiety, which is capable of a monodentate, bidentate or bridging coordination behavior utilizing either sulfur or nitrogen atoms, or both of them, in the complexes. 4 Zinc and cadmium complexes with N2S2 ligand cores are of interest as structural and spectroscopic models for metal binding sites in a number of metallothioneins and metalloregulatory proteins. 1,3-Thiazolidine-2-thione and 2,2′-bipyridine were purchased from Across. All of the solvents were used without additional purification. A polymeric complex, [Cd(C3H4NS2)2], was prepared by the method described in the literature. 3The product, [Cd(C3H4NS2)2(bipy)], was synthesized by adding 2,2′-bipyridine (3.12 g, 0.02 mol) in chloroform-dimethylformamide (1:1, 20 mL) to a suspension of a polymeric complex, [Cd(C3H4NS2)2] (1.42 g, 0.005 mol), in chloroform (10 mL) at room temperature. After stirring for two hours, a yellow solution was formed and then filtered to remove traces of solids, and was finally allowed to stand at room temperature. After several days, colorless crystals were collected and washed with toluene under a nitrogen atmosphere. These crystals were sensitive to air and suitable for a crystallographic study. The

Cu-BTC framework has received a considerable attention in recent years as a drug carrier candidate for cancer treatment due to its unique structural properties and promising biocompatibility. However, its intrinsic deficiency for medical imaging potentially limits its bioapplications; To address this subject, a magnetic nano/microscale MOF has been successfully fabricated by introducing Fe3O4 nanoparticles as an imaging agent into the porous isoreticular MOF [Cu3(BTC)2] as a drug carrier. The synthesized magnetic MOFs exhibits a high loading capacity (40.5%) toward the model anticancer DOX with an excellent pH-responsive drug release. The proposed nanocomposite not only possesses large surface area, high magnetic response, large mesopore volume, high transverse relaxivity (r2) and good stability but also exhibits superior biocompatibility, specific tumor cellular uptake, and significant cancer cell viability inhibitory effect without any targeting agent. It is expected that the synthesized magnetic nano/microcomposite may be used for clinical purposes and can also serve as a platform for photoactive antibacterial therapy ae well as pH/GSH/photo-triple-responsive nanocarrier.

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