Cu(OAc)₂/DABCO-mediated domino reaction of vinyl malononitriles with cyclic sulfamidate imines: access to 6-hydroxyaryl-2-aminonicotinonitriles

Abstract

A novel Cu(II)-salt/DABCO-mediated one-pot access to a myriad of highly-substituted biologically relevant 2-aminonicotinonitriles possessing a resourceful phenolic moiety with satisfactory yields is reported. This method involves cyclic sulfamidate imines as...

Copper(I)‐Photocatalyzed Diastereoselective Aziridination of N‐Sulfonyl Imines with Vinyl Azides: Application to Benzo[f][1,2,3]oxathiazepines Dioxides and Fused Isoxazolines

“…As part of our ongoing research interest towards the development of sustainable methods for preparing aza-heterocyclic building blocks involving cyclic N-sulfonyl imines, [19] herein we wish to report a visible-light induced and Cu(I)photocatalyzed diastereoselective aziridination reaction involving cyclic N-sulfonyl imines and vinyl azides, leading to substituted sulfamidate fused aziridines (Scheme 1g).…”

Acidic tributyl phosphonium-based ionic liquid: an efficient catalyst for preparation of diverse pyridine systems via a cooperative vinylogous anomeric-based oxidation

“…45,46 Noticeably, nicotinonitrile derivatives by pharmaceutical and medicinal functions, have a crucial role and created new insights in the design of anticancer compounds, antihistaminic, antimicrobial and etc. [47][48][49] Multicomponent strategy for the synthesis of pyridine families has a fundamental attitude of synthetic efficiency, utility high atom economy and selectivity. [50][51][52] A number of pharmaceutical applications of triaryl pyridines and nicotinonitriles are sketched in Scheme 2.…”