A series of 28 novel 2‐(4‐aminophenyl)benzothiazole analogues have been synthesized and characterized using various analytical techniques like 1H NMR, 13C NMR, electrospray ionization mass spectrometry, and IR and bioevaluated for their antiproliferative activity over a group of three human cancer cell lines, namely, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MDA‐MB‐231), using sulforhodamine B assay method. Few synthesized molecules (5a, 5c, 5d, 5f, 7b, and 7j) displayed effective growth inhibition (GI50) activity against the tested human cancer cell lines at lower micromolar concentration (GI50) values in the range 0.2–1.7 μM. Noticeably, compound 7b exhibited reasonable activity in all three cancer cell lines in the GI50 range 0.55–1.2 μM. Further, when 7b was screened for tubulin polymerization inhibition, it exhibited more than 55% inhibition at concentration of 5.0 μM. The molecular docking simulations supported the molecular interactions of the derivatives with the targeted receptor. These derivatives may serve as lead structures for development of potential anticancer drug candidates, and 7b might act as a potential microtubule polymerization inhibitor.

An efficient pyrrolidine : 4-ClBzOH salt (catalyst IV) catalyzed [3 + 3] cyclization reaction of β-alkyl-substituted nitroalkenes as 1,3-binucleophiles with various β-aryl/alkyl/ alkenyl-substituted acroleins in an open-atmosphere is reported. Eventually, this tunable organocatalytic reaction creates one CÀ C and C=C bonds selectively that turns out to have a wide substrate scope, which affords a series of substituted nitroarenes in good to high yields. In addition, several other positive features are associated with this organocatalytic approach such as evading toxic metalcatalysts, no need for external oxidant and nitrating agent, 100% carbon-economical, excellent tolerance of functionalities, water as a sole by-product, circumventing of prefunctionalized arenes etc. Moreover, a range of important hetero-and carbocycles such as 2-arylcarbazole, 2,6-diphenylindole, 2'-chloro-1,1' : 4',1''-terphenyl and 1 : 1' : 4',1''-terphenyl were accessed from nitroarenes through our unique methods.

A novel Cu(II)-salt/DABCO-mediated one-pot access to a myriad of highly-substituted biologically relevant 2-aminonicotinonitriles possessing a resourceful phenolic moiety with satisfactory yields is reported. This method involves cyclic sulfamidate imines as...